Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

Education and Training

  • Fellow In Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Swiderska-Syn, M, Xie, G, Michelotti, GA, Jewell, ML, Premont, RT, Syn, WK, and Diehl, AM. "Hedgehog regulates yes-associated protein 1 in regenerating mouse liver." July 2016.

PMID
26970079
Scholars@Duke

Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, K, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, and Suzuki, A. "A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 64, no. 1 (July 2016): 85-91.

PMID
26919573
Scholars@Duke

Machado, MV, and Diehl, AM. "Pathogenesis of Nonalcoholic Steatohepatitis." Gastroenterology 150, no. 8 (June 2016): 1769-1777.

PMID
26928243
Scholars@Duke

Boursier, J, and Diehl, AM. "Nonalcoholic Fatty Liver Disease and the Gut Microbiome." Clinics in liver disease 20, no. 2 (May 2016): 263-275. (Review)

PMID
27063268
Scholars@Duke

Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." Gut 65, no. 4 (April 2016): 683-692.

PMID
25596181
Scholars@Duke

Dattaroy, D, Seth, RK, Das, S, Alhasson, F, Chandrashekaran, V, Michelotti, G, Fan, D, Nagarkatti, M, Nagarkatti, P, Diehl, AM, and Chatterjee, S. "Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation." American journal of physiology. Gastrointestinal and liver physiology 310, no. 7 (April 2016): G510-G525.

PMID
26718771
Scholars@Duke

Markowitz, GJ, Yang, P, Fu, J, Michelotti, GA, Chen, R, Sui, J, Yang, B, Qin, WH, Zhang, Z, Wang, FS, Diehl, AM, Li, QJ, Wang, H, and Wang, XF. "Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes." Cancer research 76, no. 8 (April 2016): 2394-2405.

PMID
26893476
Scholars@Duke

Boursier, J, Barret, M, and Diehl, AM. "Answer to Ling et al "Predictive roles of gut dysbiosis on the severity of NAFLD"." Hepatology (Baltimore, Md.) (March 21, 2016). (Letter)

PMID
26998974
Scholars@Duke

Guy, CD, and Diehl, AM. "Reply." Hepatology (Baltimore, Md.) 63, no. 3 (March 2016): 1057-1058. (Letter)

PMID
26206676
Scholars@Duke

Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers." The Journal of pathology 238, no. 4 (March 2016): 531-542.

PMID
26415102
Scholars@Duke

Pages