Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

Education and Training

  • Fellow In Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." Gut 65, no. 4 (April 2016): 683-692.

PMID
25596181
Full Text

Machado, MV, Kruger, L, Jewell, ML, Michelotti, GA, Pereira, TA, Xie, G, Moylan, CA, and Diehl, AM. "Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model." Digestive diseases and sciences 61, no. 1 (January 2016): 137-148.

PMID
26403427
Full Text

Machado, MV, Michelotti, GA, Pereira, TA, Xie, G, Premont, R, Cortez-Pinto, H, and Diehl, AM. "Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease." Journal of hepatology 63, no. 4 (October 2015): 962-970.

PMID
26070409
Full Text

Coombes, JD, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, MA, Shetty, S, Oo, YH, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, PC, Williams, R, Canbay, A, Adams, DH, Diehl, AM, van Grunsven, LA, Choi, SS, and Syn, WK. "Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice." Gut 64, no. 7 (July 2015): 1120-1131.

PMID
24902765
Full Text

Machado, MV, Michelotti, GA, Pereira, TDEA, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, CD, Bohinc, B, Lindblom, KR, Johnson, E, Kornbluth, S, and Diehl, AM. "Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis." Gut 64, no. 7 (July 2015): 1148-1157.

PMID
25053716
Full Text

Das, S, Alhasson, F, Dattaroy, D, Pourhoseini, S, Seth, RK, Nagarkatti, M, Nagarkatti, PS, Michelotti, GA, Diehl, AM, Kalyanaraman, B, and Chatterjee, S. "NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment." The American journal of pathology 185, no. 7 (July 2015): 1944-1957.

PMID
25989356
Full Text

Angulo, P, Machado, MV, and Diehl, AM. "Fibrosis in nonalcoholic Fatty liver disease: mechanisms and clinical implications." Seminars in liver disease 35, no. 2 (May 14, 2015): 132-145.

PMID
25974899
Full Text

Guy, C, Suzuki, A, Abdelmalek, M, Burchette, J, and Diehl, AM. "Reply." Hepatology 61, no. 5 (May 2015): 1770-1771.

Full Text

Diehl, AM. "Prometheus and progenitors." Hepatology (Baltimore, Md.) 61, no. 4 (April 2015): 1427-1429.

PMID
25545250
Full Text

Markowitz, GJ, Michelotti, GA, Diehl, AM, and Wang, XF. "Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma." Science bulletin 60, no. 8 (April 2015): 762-772.

PMID
26029472
Full Text

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