Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Oh, S-H, Swiderska-Syn, M, Jewell, ML, Premont, RT, and Diehl, AM. "Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes." Journal of Hepatology 69, no. 2 (August 2018): 359-367.

PMID
29758331
Full Text

Castro, RE, and Diehl, AM. "Towards a definite mouse model of NAFLD." Journal of Hepatology 69, no. 2 (August 2018): 272-274.

PMID
29858042
Full Text

Verdelho Machado, M, and Diehl, AM. "The hedgehog pathway in nonalcoholic fatty liver disease." Critical Reviews in Biochemistry and Molecular Biology 53, no. 3 (June 2018): 264-278.

PMID
29557675
Full Text

Chen, KY, Shen, X, and Diehl, AM. "Prometheus revisited." Journal of Clinical Investigation 128, no. 6 (June 1, 2018): 2192-2193. (Review)

Full Text

Jensen, T, Abdelmalek, MF, Sullivan, S, Nadeau, KJ, Green, M, Roncal, C, Nakagawa, T, Kuwabara, M, Sato, Y, Kang, D-H, Tolan, DR, Sanchez-Lozada, LG, Rosen, HR, Lanaspa, MA, Diehl, AM, and Johnson, RJ. "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease." Journal of Hepatology 68, no. 5 (May 2018): 1063-1075. (Review)

PMID
29408694
Full Text

Alhasson, F, Seth, RK, Sarkar, S, Kimono, DA, Albadrani, MS, Dattaroy, D, Chandrashekaran, V, Scott, GI, Raychoudhury, S, Nagarkatti, M, Nagarkatti, P, Diehl, AM, and Chatterjee, S. "High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease." Redox biology 17 (April 7, 2018): 1-15.

PMID
29660503
Full Text

Du, K, Hyun, J, Premont, RT, Choi, SS, Michelotti, GA, Swiderska-Syn, M, Dalton, GD, Thelen, E, Rizi, BS, Jung, Y, and Diehl, AM. "Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells." April 2018.

PMID
29305935
Full Text

Diehl, AM, and Day, C. "Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis." The New England Journal of Medicine 377, no. 21 (November 2017): 2063-2072. (Review)

PMID
29166236
Full Text

Machado, MV, and Diehl, AM. "Hedgehog signalling in liver pathophysiology." Journal of hepatology (October 26, 2017). (Review)

PMID
29107151
Full Text

Chandrashekaran, V, Seth, RK, Dattaroy, D, Alhasson, F, Ziolenka, J, Carson, J, Berger, FG, Kalyanaraman, B, Diehl, AM, and Chatterjee, S. "HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease." Redox Biology 13 (October 2017): 8-19.

PMID
28551086
Full Text

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