Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Distinguished Professor of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Alexopoulos, Anastasia-Stefania, Matthew J. Crowley, Ying Wang, Cynthia A. Moylan, Cynthia D. Guy, Ricardo Henao, Dawn L. Piercy, et al. “Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.” Hepatology 74, no. 3 (September 2021): 1220–33. https://doi.org/10.1002/hep.31806.

PMID
33724511
Full Text

Hyun, Jeongeun, Muthana Al Abo, Rajesh Kumar Dutta, Seh Hoon Oh, Kun Xiang, Xiyou Zhou, Raquel Maeso-Díaz, et al. “Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease.” J Hepatol 75, no. 3 (September 2021): 623–33. https://doi.org/10.1016/j.jhep.2021.04.033.

PMID
33964370
Full Text

Du, Kuo, Seh Hoon Oh, Rajesh K. Dutta, Tianai Sun, Wen-Hsuan Yang, Jen-Tsan Chi, and Anna Mae Diehl. “Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.” Liver Int 41, no. 9 (September 2021): 2214–27. https://doi.org/10.1111/liv.14945.

PMID
33991158
Full Text

Chen, Tianyi, and Anna Mae Diehl. “A Beautiful Day in the Neighborhood: Application of Single-Cell Transcriptomics to Unravel Liver Cell Heterogeneity in Diseased Human Livers.” Hepatology 74, no. 2 (August 2021): 547–49. https://doi.org/10.1002/hep.31827.

PMID
33756021
Full Text

Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.

PMID
33819485
Full Text

Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “REPLY.” Hepatology (Baltimore, Md.) 73, no. 4 (April 2021): 1625. https://doi.org/10.1002/hep.31593.

PMID
33040372
Full Text

Peters, Anthony E., Ambarish Pandey, Colby Ayers, Kara Wegermann, Robert W. McGarrah, Justin L. Grodin, Manal F. Abdelmalek, et al. “Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT.” Esc Heart Fail 8, no. 2 (April 2021): 842–48. https://doi.org/10.1002/ehf2.13250.

PMID
33586354
Full Text

Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “Tackling Nonalcoholic Fatty Liver Disease: Three Targeted Populations.” Hepatology 73, no. 3 (March 2021): 1199–1206. https://doi.org/10.1002/hep.31533.

PMID
32865242
Full Text

Canivet, Clemence M., Norma David, Helene Pailhoriès, Martial Briand, Cynthia D. Guy, Olivier Bouchez, Gilles Hunault, et al. “Cross-linkage between bacterial taxonomy and gene functions: a study of metagenome-assembled genomes of gut microbiota in adult non-alcoholic fatty liver disease.” Aliment Pharmacol Ther 53, no. 6 (March 2021): 722–32. https://doi.org/10.1111/apt.16262.

PMID
33482026
Full Text

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