Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Distinguished Professor of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Pailhoriès, Hélène, Jerome Boursier, and Anna Mae Diehl. “Determinants of the severity of fatty liver diseases: Need all the pieces to solve the puzzle.” Hepatology 75, no. 4 (April 2022): 782–84. https://doi.org/10.1002/hep.32282.

PMID
34919744
Full Text

Moylan, Cynthia A., Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, et al. “Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.” Epigenetics, February 21, 2022, 1–16. https://doi.org/10.1080/15592294.2022.2039850.

PMID
35188871
Full Text

Maeso-Díaz, Raquel, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, and Anna Mae Diehl. “Aging reduces liver resiliency by dysregulating Hedgehog signaling.” In Aging Cell, 21:e13530, 2022. https://doi.org/10.1111/acel.13530.

PMID
34984806
Full Text

Baptissart, Marine, Christine M. Bradish, Brie S. Jones, Evan Walsh, Jesse Tehrani, Vicmarie Marrero-Colon, Sanya Mehta, et al. “Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.” Hepatology, January 26, 2022. https://doi.org/10.1002/hep.32363.

PMID
35083765
Full Text

Woreta, Tinsay A., Mark L. Van Natta, Mariana Lazo, Arunkumar Krishnan, Brent A. Neuschwander-Tetri, Rohit Loomba, Anna Mae Diehl, et al. “Validation of the accuracy of the FAST™ score for detecting patients with at-risk nonalcoholic steatohepatitis (NASH) in a North American cohort and comparison to other non-invasive algorithms.” Plos One 17, no. 4 (2022): e0266859. https://doi.org/10.1371/journal.pone.0266859.

PMID
35427375
Full Text

Fudim, Marat, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, et al. “Nonalcoholic Fatty Liver Disease and Risk of Heart Failure Among Medicare Beneficiaries.” J Am Heart Assoc 10, no. 22 (November 16, 2021): e021654. https://doi.org/10.1161/JAHA.121.021654.

PMID
34755544
Full Text

Salah, Husam M., Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, et al. “Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction.” Jacc Basic Transl Sci 6, no. 11 (November 2021): 918–32. https://doi.org/10.1016/j.jacbts.2021.07.010.

PMID
34869957
Full Text

Sanyal, Arun J., Mark L. Van Natta, Jeanne Clark, Brent A. Neuschwander-Tetri, AnnaMae Diehl, Srinivasan Dasarathy, Rohit Loomba, et al. “Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease.” N Engl J Med 385, no. 17 (October 21, 2021): 1559–69. https://doi.org/10.1056/NEJMoa2029349.

PMID
34670043
Full Text

Dalton, George D., Seh-Hoon Oh, Linda Tang, Stephanie Zhang, Amanda L. Brown, Venkateshwari Varadharajan, Camelia Baleanu-Gogonea, et al. “Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.” Iscience 24, no. 9 (September 24, 2021): 103089. https://doi.org/10.1016/j.isci.2021.103089.

PMID
34568800
Full Text

Alexopoulos, Anastasia-Stefania, Matthew J. Crowley, Ying Wang, Cynthia A. Moylan, Cynthia D. Guy, Ricardo Henao, Dawn L. Piercy, et al. “Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.” Hepatology 74, no. 3 (September 2021): 1220–33. https://doi.org/10.1002/hep.31806.

PMID
33724511
Full Text

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