Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Hyun, J, Oh, S-H, Premont, RT, Guy, CD, Berg, CL, and Diehl, AM. "Dysregulated activation of fetal liver programme in acute liver failure." Gut (January 22, 2019).

PMID
30670575
Full Text

Corey, KE, Wilson, LA, Altinbas, A, Yates, KP, Kleiner, DE, Chung, RT, Krauss, RM, Chalasani, N, Bringman, D, Dasarathy, S, Feldstein, A, Hawkins, C, Liu, YC, McCullough, A, Sargent, R, Stager, M, Abdelmalek, M, Diehl, AM, Gottfried, M, Guy, C, Killenberg, P, Kwan, S, Pan, YP, Piercy, D, Smith, M, Pfeifer, K, Scheimann, AO, Torbenson, M, Bhimalli, P, Byam, E, Cummings, OW, Klipsch, A, Lee, L, Molleston, JP, Ragozzino, L, Subbarao, G, Vuppalanchi, R, Barlow, S, Brunt, EM, Derdoy, J, Hoffmann, J, King, D, Siegner, J, Stewart, S, Neuschwander-Tetri, BA, Thompson, J, Abrams, SH, Arceo, D, Espinosa, D, Fairly, LA, Behling, C, Clark, L, Durelle, J, Lavine, JE, Mendoza, S, Parman, Z, Patton, H, Schwimmer, JB, Sirlin, C, Stein, T, Bambha, K, Bass, NM, Ferrell, LD, Filipowski, D, Merriman, R, Pabst, M, Rosenthal, M, Rosenthal, P, Steel, T, Coffey, M, Kowdley, KV, Mooney, J, Murray, KF, Nelson, J, Saunders, C, Yeh, M, Young, M, Boyett, S, Bryan, D, Contos, MJ, Fuchs, M, Jones, A, Luketic, VAC, Sandhu, B, Sanyal, AJ, Sargeant, C, White, M, Mohan, P, Nair, K, Doo, E, Hoofnagle, J, Robuck, PR, Huang, TTK, Belt, P, Brancati, F, Clark, J, Colvin, R, Donithan, M, Green, M, and Hollick, R. "Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial." Alimentary Pharmacology and Therapeutics (January 1, 2019).

Full Text

Younossi, Z, Stepanova, M, Sanyal, AJ, Harrison, SA, Ratziu, V, Abdelmalek, MF, Diehl, AM, Caldwell, S, Shiffman, ML, Schall, RA, McColgan, B, Subramanian, GM, Myers, RP, Muir, A, Afdhal, NH, Bosch, J, and Goodman, Z. "The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options." Journal of Hepatology 69, no. 6 (December 2018): 1365-1370.

PMID
30144554
Full Text

Dattaroy, D, Seth, RK, Sarkar, S, Kimono, D, Albadrani, M, Chandrashekaran, V, Hasson, FA, Singh, UP, Fan, D, Nagarkatti, M, Nagarkatti, P, Diehl, AM, and Chatterjee, S. "Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent." European Journal of Pharmacology 841 (December 2018): 33-48.

PMID
30194936
Full Text

Reese, AT, Pereira, FC, Schintlmeister, A, Berry, D, Wagner, M, Hale, LP, Wu, A, Jiang, S, Durand, HK, Zhou, X, Premont, RT, Diehl, AM, O'Connell, TM, Alberts, SC, Kartzinel, TR, Pringle, RM, Dunn, RR, Wright, JP, and David, LA. "Microbial nitrogen limitation in the mammalian large intestine." Nature Microbiology 3, no. 12 (December 2018): 1441-1450.

PMID
30374168
Full Text

Loomba, R, Jain, A, Diehl, AM, Guy, CD, Portenier, D, Sudan, R, Singh, S, Faulkner, C, Richards, L, Hester, KD, Okada, L, Li, X-J, Mimms, L, and Abdelmalek, MF. "Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association (November 15, 2018).

PMID
30448594
Full Text

Zhu, C, Kim, K, Wang, X, Bartolome, A, Salomao, M, Dongiovanni, P, Meroni, M, Graham, MJ, Yates, KP, Diehl, AM, Schwabe, RF, Tabas, I, Valenti, L, Lavine, JE, and Pajvani, UB. "Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis." Science Translational Medicine 10, no. 468 (November 2018).

PMID
30463916
Full Text

Harrison, SA, Abdelmalek, MF, Caldwell, S, Shiffman, ML, Diehl, AM, Ghalib, R, Lawitz, EJ, Rockey, DC, Schall, RA, Jia, C, McColgan, BJ, McHutchison, JG, Subramanian, GM, Myers, RP, Younossi, Z, Ratziu, V, Muir, AJ, Afdhal, NH, Goodman, Z, Bosch, J, Sanyal, AJ, and GS-US-321-0105 and GS-US-321-0106 Investigators, . "Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis." Gastroenterology 155, no. 4 (October 2018): 1140-1153.

PMID
29990488
Full Text

Yang, JD, Abdelmalek, MF, Guy, CD, Diehl, AM, and Suzuki, A. "Reply." Clinical Gastroenterology and Hepatology 16, no. 10 (October 1, 2018): 1684-null. (Letter)

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Yang, JD, Abdelmalek, MF, Guy, CD, Diehl, AM, and Suzuki, A. "Reply." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 16, no. 10 (October 2018): 1684-null. (Letter)

PMID
28502788
Full Text

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