Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Campus mail Duke Box 3256, 905 S. Lasalle Street, Gsrb 1, Durham, NC 27710
Phone (919) 684-4173
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

Education and Training

  • Fellow In Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Coombes, JD, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, MA, Shetty, S, Oo, YH, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, PC, Williams, R, Canbay, A, Adams, DH, Diehl, AM, van Grunsven, LA, Choi, SS, and Syn, WK. "Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice." Gut 64, no. 7 (July 2015): 1120-1131.

PMID
24902765
Full Text

Machado, MV, Michelotti, GA, Pereira, TA, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, CD, Bohinc, B, Lindblom, KR, Johnson, E, Kornbluth, S, and Diehl, AM. "Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis." Gut 64, no. 7 (July 2015): 1148-1157.

PMID
25053716
Full Text

Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, JL, and Diehl, AM. "Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity." Hepatology (Baltimore, Md.) 61, no. 1 (January 2015): 98-107.

PMID
24849310
Full Text

Bohinc, BN, Michelotti, G, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, D, Kruger, L, Swiderska-Syn, M, Machado, M, Pereira, T, Zavacki, AM, Abdelmalek, M, and Diehl, AM. "Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism." Endocrinology 155, no. 11 (November 2014): 4591-4601.

PMID
25121996
Full Text

Soeda, J, Mouralidarane, A, Ray, S, Novelli, M, Thomas, S, Roskams, T, Diehl, AM, and Oben, JA. "The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice." Hepatology (Baltimore, Md.) 60, no. 3 (September 2014): 1023-1034.

PMID
24923719
Full Text

Swiderska-Syn, M, Syn, WK, Xie, G, Krüger, L, Machado, MV, Karaca, G, Michelotti, GA, Choi, SS, Premont, RT, and Diehl, AM. "Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy." Gut 63, no. 8 (August 2014): 1333-1344.

PMID
24173292
Full Text

Siddique, A, Nelson, JE, Aouizerat, B, Yeh, MM, and Kowdley, KV. "Iron Deficiency in Patients With Nonalcoholic Fatty Liver Disease Is Associated With Obesity, Female Gender, and Low Serum Hepcidin." Clinical Gastroenterology and Hepatology 12, no. 7 (July 2014): 1170-1178.

Full Text

Choi, SS, Claridge, LC, Jhaveri, R, Swiderska-Syn, M, Clark, P, Suzuki, A, Pereira, TA, Mi, Z, Kuo, PC, Guy, CD, Pereira, FE, Diehl, AM, Patel, K, and Syn, WK. "Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication." Clinical science (London, England : 1979) 126, no. 12 (June 2014): 845-855.

PMID
24438228
Full Text

Chan, IS, Guy, CD, Machado, MV, Wank, A, Kadiyala, V, Michelotti, G, Choi, S, Swiderska-Syn, M, Karaca, G, Pereira, TA, Yip-Schneider, MT, Max Schmidt, C, and Diehl, AM. "Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis." Alcohol Clin Exp Res 38, no. 3 (March 2014): 787-800.

PMID
24164383
Full Text

Hyun, J, Choi, S, Diehl, AME, and Jung, Y. "Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse." Journal of Molecular Histology 45, no. 1 (February 1, 2014): 103-112.

Full Text

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