Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978


Block, Keith I., Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, ARM Ruhul Amin, Amr Amin, Katia Aquilano, et al. “Designing a broad-spectrum integrative approach for cancer prevention and treatment..” Semin Cancer Biol 35 Suppl (December 2015): S276–304.

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Pereira, Thiago A., Wing-Kin Syn, Mariana V. Machado, Paula V. Vidigal, Vivian Resende, Izabela Voieta, Guanhua Xie, et al. “Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni..” Clin Sci (Lond) 129, no. 10 (November 2015): 875–83.

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Michelotti, Gregory, Xiaoyin Jiang, Julie Ann Sosa, Anna Mae Diehl, and Brittany Bohinc Henderson. “LGR5 is associated with tumor aggressiveness in papillary thyroid cancer..” Oncotarget 6, no. 33 (October 27, 2015): 34549–60.

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Uschner, Frank E., Ganesh Ranabhat, Michaela Granzow, Steve S. Choi, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.” In Hepatology, 62:249A-249A. WILEY-BLACKWELL, 2015.


Boursier, Jerome, Olaf Mueller, Matthieu Barret, Mariana V. Machado, Lionel Fizanne, Cynthia D. Guy, John F. Rawls, et al. “Increasing severity of NAFLD is associated with gut dysbiosis and modification of the metabolic function of the gut microbiota.” In Hepatology, 62:1274A-1274A. WILEY-BLACKWELL, 2015.


Machado, Mariana V., Gregory A. Michelotti, Guanhua Xie, Thiago A. Pereira, Mark Jewell, Richard T. Premont, and Anna Mae Diehl. “Ancestral starvation-activated caspase-2 promotes obesity, the metabolic syndrome and Nonalcoholic fatty liver disease.” In Hepatology, 62:670A-670A. WILEY-BLACKWELL, 2015.


Harrison, Stephen A., Zachary D. Goodman, Vlad Ratziu, Rohit Loomba, Anna Mae Diehl, Eric Lawitz, Holger Hinrichsen, et al. “Serum lysyl oxidase-like-2 (sLOXL2) levels correlate with fibrosis stage in patients with nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:910A-910A. WILEY-BLACKWELL, 2015.


Henao, Ricardo, Nigar Hasanaliyeva, Lauren N. Bell, Jacob Wulff, Regis Perichon, Cynthia A. Moylan, James T. Lu, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:290A-291A. WILEY-BLACKWELL, 2015.


Moylan, Cynthia A., Susan K. Murphy, Carole Grenier, Manal F. Abdelmalek, and Anna Mae Diehl. “DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:648A-649A. WILEY-BLACKWELL, 2015.


Hasanaliyeva, Nigar, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Robert Streilein, Russell Hall, Anna Mae Diehl, and Manal F. Abdelmalek. “IL-8 and MCP1 are Independently Associated with Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:1265A-1265A. WILEY-BLACKWELL, 2015.