Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Hirschey, MD, DeBerardinis, RJ, Diehl, AME, Drew, JE, Frezza, C, Green, MF, Jones, LW, Ko, YH, Le, A, Lea, MA, Locasale, JW, Longo, VD, Lyssiotis, CA, McDonnell, E, Mehrmohamadi, M, Michelotti, G, Muralidhar, V, Murphy, MP, Pedersen, PL, Poore, B, Raffaghello, L, Rathmell, JC, Sivanand, S, Vander Heiden, MG, Wellen, KE, and Target Validation Team, . "Dysregulated metabolism contributes to oncogenesis." Seminars in Cancer Biology 35 Suppl (December 2015): S129-S150. (Review)

PMID
26454069
Full Text

Block, KI, Gyllenhaal, C, Lowe, L, Amedei, A, Amin, ARMR, Amin, A, Aquilano, K, Arbiser, J, Arreola, A, Arzumanyan, A, Ashraf, SS, Azmi, AS, Benencia, F, Bhakta, D, Bilsland, A, Bishayee, A, Blain, SW, Block, PB, Boosani, CS, Carey, TE, Carnero, A, Carotenuto, M, Casey, SC, Chakrabarti, M, Chaturvedi, R, Chen, GZ, Chen, H, Chen, S, Chen, YC, Choi, BK, Ciriolo, MR, Coley, HM, Collins, AR, Connell, M, Crawford, S, Curran, CS, Dabrosin, C, Damia, G, Dasgupta, S, DeBerardinis, RJ, Decker, WK, Dhawan, P, Diehl, AME, Dong, J-T, Dou, QP, Drew, JE, Elkord, E, El-Rayes, B, Feitelson, MA, Felsher, DW, Ferguson, LR, Fimognari, C, Firestone, GL, Frezza, C, Fujii, H, Fuster, MM, Generali, D, Georgakilas, AG, Gieseler, F, Gilbertson, M, Green, MF, Grue, B, Guha, G, Halicka, D, Helferich, WG, Heneberg, P, Hentosh, P, Hirschey, MD, Hofseth, LJ, Holcombe, RF, Honoki, K, Hsu, H-Y, Huang, GS, Jensen, LD, Jiang, WG, Jones, LW, Karpowicz, PA, Keith, WN, Kerkar, SP, Khan, GN, Khatami, M, Ko, YH, Kucuk, O, Kulathinal, RJ, Kumar, NB, Kwon, BS, Le, A, Lea, MA, Lee, H-Y, Lichtor, T, Lin, L-T, Locasale, JW, Lokeshwar, BL, Longo, VD, Lyssiotis, CA, MacKenzie, KL, Malhotra, M, Marino, M, Martinez-Chantar, ML, Matheu, A, Maxwell, C, McDonnell, E, Meeker, AK, Mehrmohamadi, M, Mehta, K, Michelotti, GA, Mohammad, RM, Mohammed, SI, Morre, DJ, Muralidhar, V, Muqbil, I, Murphy, MP, Nagaraju, GP, Nahta, R, Niccolai, E, Nowsheen, S, Panis, C, Pantano, F, Parslow, VR, Pawelec, G, Pedersen, PL, Poore, B, Poudyal, D, Prakash, S, Prince, M, Raffaghello, L, Rathmell, JC, Rathmell, WK, Ray, SK, Reichrath, J, Rezazadeh, S, Ribatti, D, Ricciardiello, L, Robey, RB, Rodier, F, Rupasinghe, HPV, Russo, GL, Ryan, EP, Samadi, AK, Sanchez-Garcia, I, Sanders, AJ, Santini, D, Sarkar, M, Sasada, T, Saxena, NK, Shackelford, RE, Shantha Kumara, HMC, Sharma, D, Shin, DM, Sidransky, D, Siegelin, MD, Signori, E, Singh, N, Sivanand, S, Sliva, D, Smythe, C, Spagnuolo, C, Stafforini, DM, Stagg, J, Subbarayan, PR, Sundin, T, Talib, WH, Thompson, SK, Tran, PT, Ungefroren, H, Vander Heiden, MG, Venkateswaran, V, Vinay, DS, Vlachostergios, PJ, Wang, Z, Wellen, KE, Whelan, RL, Yang, ES, Yang, H, Yang, X, Yaswen, P, Yedjou, C, Yin, X, Zhu, J, and Zollo, M. "Designing a broad-spectrum integrative approach for cancer prevention and treatment." Seminars in Cancer Biology 35 Suppl (December 2015): S276-S304. (Review)

PMID
26590477
Full Text

Pereira, TA, Syn, W-K, Machado, MV, Vidigal, PV, Resende, V, Voieta, I, Xie, G, Otoni, A, Souza, MM, Santos, ET, Chan, IS, Trindade, GVM, Choi, SS, Witek, RP, Pereira, FE, Secor, WE, Andrade, ZA, Lambertucci, JR, and Diehl, AM. "Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni." Clinical Science (London, England : 1979) 129, no. 10 (November 2015): 875-883.

PMID
26201095
Full Text

Xie, G, Swiderska-Syn, M, Machado, MV, Jewell, M, Premont, RT, Michelotti, GA, Teperino, R, and Diehl, AM. "Characterization of obesity-related modifications in hepatic stellate cells." October 2015.

Scholars@Duke

Coombes, JD, Manka, PP, Swiderska-Syn, M, Riva, A, Reid, D, Claridge, LC, Dolle, L, Younis, R, Briones-Orta, MA, Kitamura, N, Mi, Z, Kuo, PC, Williams, R, Diehl, AM, Chokshi, S, Eksteen, B, Canbay, A, and Syn, W-K. "Osteopontin promotes cholangiocyte chemokine secretion and macrophage accumulation in mice." October 2015.

Scholars@Duke

Sanyal, AJ, Goodman, ZD, Abdelmalek, MF, Harrison, SA, Rockey, DC, Diehl, AM, Caldwell, SH, Shiffman, ML, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Ratziu, V, Afdhal, NH, and Bosch, J. "Clinical and histologic correlates of the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

Sundaram, S, Swiderska-Syn, M, Sokol, RJ, Pan, Z, Halbower, AC, Capocelli, KE, Robbins, KN, and Diehl, AM. "Nocturnal Hypoxia is associated with Hedgehog Signaling and Severity of Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD)." October 2015.

Scholars@Duke

Machado, MV, Michelotti, GA, Pereira, TA, Xie, G, Premont, R, Cortez-Pinto, H, and Diehl, AM. "Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease." Journal of hepatology 63, no. 4 (October 2015): 962-970.

PMID
26070409
Full Text

Michelotti, G, Jiang, X, Sosa, JA, Diehl, AM, and Henderson, BB. "LGR5 is associated with tumor aggressiveness in papillary thyroid cancer." Oncotarget 6, no. 33 (October 2015): 34549-34560.

PMID
26416247
Full Text

Uschner, FE, Ranabhat, G, Granzow, M, Choi, SS, Klein, S, Schierwagen, R, Raskopf, E, Gautsch, S, Van der Ven, PF, Strassburg, CP, Fuerst, DO, Hiththetiya, K, Sauerbruch, T, Diehl, AM, and Trebicka, J. "Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension." October 2015.

Scholars@Duke

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