Hematologic Malignancies and Cellular Therapy

Anthony D Sung, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Campus mail DUMC Box 3961, Durham, NC 27712
Phone (919) 668-1002
Email address anthony.sung@duke.edu

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

In Their Words

Education and Training

  • Fellowship, Hematology Oncology, Duke University School of Medicine, 2011 - 2014
  • Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, 2008 - 2011
  • M.D., Harvard University, 2008

Grants

Publications

O'Sullivan, ML, Shelby, RA, Dorfman, CS, Kelleher, SA, Fisher, HM, Rowe Nichols, KA, Keefe, FJ, Sung, AD, and Somers, TJ. "The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26, no. 4 (April 2018): 1243-1252.

PMID
29124418
Full Text

Guo, M, Chao, NJ, Li, J-Y, Rizzieri, DA, Sun, Q-Y, Mohrbacher, A, Krakow, EF, Sun, W-J, Shen, X-L, Zhan, X-R, Wu, D-P, Liu, L, Wang, J, Zhou, M, Yang, L-H, Bao, Y-Y, Dong, Z, Cai, B, Hu, K-X, Yu, C-L, Qiao, J-H, Zuo, H-L, Huang, Y-J, Sung, AD, Qiao, J-X, Liu, Z-Q, Liu, T-Q, Yao, B, Zhao, H-X, Qian, S-X, Liu, W-W, Forés, R, Duarte, RF, Ai, H-S, and Microtransplantation Interest Group, . "HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia: Results From the Microtransplantation Interest Group." JAMA oncology 4, no. 1 (January 2018): 54-62.

PMID
28910431
Full Text

Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (December 12, 2017).

PMID
29246821
Full Text

Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157.

PMID
28392378
Full Text

Sivaraj, D, Green, MM, Li, Z, Sung, AD, Sarantopoulos, S, Kang, Y, Long, GD, Horwitz, ME, Lopez, RD, Sullivan, KM, Rizzieri, DA, Chao, NJ, and Gasparetto, C. "Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 2 (February 2017): 262-268.

PMID
27856369
Full Text

Krakow, EF, Ai, H-S, Shaffer, B, Delisle, J-S, Hu, K-X, and Sung, AD. "Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers." Current drug targets 18, no. 3 (January 2017): 281-295. (Review)

PMID
25738297
Full Text

Sung, A, and Horwitz, M. "Reply to Strahilevitz and Shapira." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (December 12, 2016).

PMID
27956457
Scholars@Duke

Sung, AD, Sung, JAM, Thomas, S, Hyslop, T, Gasparetto, C, Long, G, Rizzieri, D, Sullivan, KM, Corbet, K, Broadwater, G, Chao, NJ, and Horwitz, ME. "Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 63, no. 8 (October 2016): 999-1006.

PMID
27481873
Full Text

Green, MMB, Chao, N, Chhabra, S, Corbet, K, Gasparetto, C, Horwitz, A, Li, Z, Venkata, JK, Long, G, Mims, A, Rizzieri, D, Sarantopoulos, S, Stuart, R, Sung, AD, Sullivan, KM, Costa, L, Horwitz, M, and Kang, Y. "Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery." Journal of hematology & oncology 9, no. 1 (August 17, 2016): 71-.

PMID
27535663
Full Text

Wild, D, Sung, AD, Cardona, D, Cirricione, C, Sullivan, K, Detweiler, C, Shealy, M, Balmadrid, B, Rowes, KL, Chao, N, Piryani, S, Karimabad, HM, Martin, P, and Poleski, M. "The Diagnostic Yield of Site and Symptom-Based Biopsies for Acute Gastrointestinal Graft-Versus-Host Disease: A 5-Year Retrospective Review." Digestive diseases and sciences 61, no. 3 (March 2016): 806-813.

PMID
26537485
Full Text

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