Hematologic Malignancies and Cellular Therapy

Anthony D Sung, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address anthony.sung@duke.edu

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

In Their Words

Education and Training

  • Fellowship, Hematology Oncology, Duke University School of Medicine, 2011 - 2014
  • Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, 2008 - 2011
  • M.D., Harvard University , 2008

Grants

Publications

Spees, LP, Martin, PL, Kurtzberg, J, Stokhuyzen, A, McGill, L, Prasad, VK, Driscoll, TA, Parikh, SH, Page, KM, Vinesett, R, Severyn, C, Sung, AD, Proia, AD, Jenkins, K, Arshad, M, Steinbach, WJ, Seed, PC, and Kelly, MS. "Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 25, no. 4 (April 2019): 756-763.

PMID
30481599
Full Text

Peled, JU, Gomes, ALC, Stein-Thoeringer, CK, Slingerland, JB, Slingerland, AE, Weber, D, Markey, KA, Smith, M, Ponce, D, Clurman, A, Sung, AD, Hashimoto, D, Maloy, M, Khan, N, Gyurkocza, B, Giralt, S, Perales, M-A, Jenq, RR, Taur, Y, Joao, XB, Pamer, EG, Teshima, T, Chao, NJ, Holler, E, and van den Brink, MRM. "Multicenter Microbiota Analysis Indicates That Pre-HCT Microbiota Injury Is Prevalent across Geography and Predicts Poor Overall Survival." 60th Annual Meeting of the American-Society-of-Hematology (ASH). San Diego, CA. December 1, 2018 - December 4, 2018.: AMER SOC HEMATOLOGY, November 29, 2018.

Full Text

Stein-Thoeringer, CK, Peled, JU, Gomes, ALC, Lazrak, A, Docampo, MD, Slingerland, AE, Nichols, K, Shono, Y, Weber, D, Sung, AD, Hashimoto, D, Cross, J, Teshima, T, Holler, E, Chao, NJ, Pamer, EG, and van den Brink, MRM. "Intestinal Enterococcus Is a Major Risk Factor for the Development of Acute Gvhd." 60th Annual Meeting of the American-Society-of-Hematology (ASH). San Diego, CA. December 1, 2018 - December 4, 2018.: AMER SOC HEMATOLOGY, November 29, 2018.

Full Text

Khan, N, Peled, JU, Gomes, AL, Devlin, SM, Rondon-Clavo, C, Clurman, A, Slingerland, JB, Slingerland, AE, Maloy, M, Sung, AD, Chao, NJ, Sauter, CS, Landau, HJ, Ponce, D, Gyurkocza, B, Shah, GL, Scordo, M, Dahi, PB, Perales, M-A, Jenq, RR, Giralt, S, Pamer, EG, and van den Brink, MRM. "Loss of Microbiota Diversity after Autologous Stem Cell Transplant Is Comparable to Injury in Allogeneic Stem Cell Transplant." 60th Annual Meeting of the American-Society-of-Hematology (ASH). San Diego, CA. December 1, 2018 - December 4, 2018.: AMER SOC HEMATOLOGY, November 29, 2018.

Full Text

Cardona, DM, Detweiler, CJ, Shealy, MJ, Sung, AD, Wild, DM, Poleski, MH, Balmadrid, BL, Cirrincione, CT, Howell, DN, and Sullivan, KM. "Use of the National Institutes of Health Consensus Guidelines Improves the Diagnostic Sensitivity of Gastrointestinal Graft-Versus-Host Disease." Archives of Pathology & Laboratory Medicine 142, no. 9 (September 2018): 1098-1105.

PMID
29697275
Full Text

Detweiler, CJ, Mueller, SB, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD." Journal of Pediatric Hematology Oncology 40, no. 6 (August 1, 2018): E364-E368. (Academic Article)

Full Text

Detweiler, CJ, Mueller, SB, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD." Journal of Pediatric Hematology/Oncology 40, no. 6 (August 2018): e364-e368.

PMID
29846280
Full Text

Andermann, TM, Peled, JU, Ho, C, Reddy, P, Riches, M, Storb, R, Teshima, T, van den Brink, MRM, Alousi, A, Balderman, S, Chiusolo, P, Clark, WB, Holler, E, Howard, A, Kean, LS, Koh, AY, McCarthy, PL, McCarty, JM, Mohty, M, Nakamura, R, Rezvani, K, Segal, BH, Shaw, BE, Shpall, EJ, Sung, AD, Weber, D, Whangbo, J, Wingard, JR, Wood, WA, Perales, M-A, Jenq, RR, Bhatt, AS, and Blood and Marrow Transplant Clinical Trials Network, . "The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 7 (July 2018): 1322-1340.

PMID
29471034
Full Text

Messina, JA, Sinha, R, Starr, K, Arshad, M, Alexander, BD, Chao, NJ, and Sung, AD. "Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia." Open Forum Infectious Diseases 5, no. 6 (June 2018): ofy107-null.

PMID
29977964
Full Text

O'Sullivan, ML, Shelby, RA, Dorfman, CS, Kelleher, SA, Fisher, HM, Rowe Nichols, KA, Keefe, FJ, Sung, AD, and Somers, TJ. "The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 26, no. 4 (April 2018): 1243-1252.

PMID
29124418
Full Text

Pages