Hematologic Malignancies and Cellular Therapy

Anthony D Sung, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address anthony.sung@duke.edu

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

In Their Words

Education and Training

  • Fellowship, Hematology Oncology, Duke University School of Medicine, 2011 - 2014
  • Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, 2008 - 2011
  • M.D., Harvard University , 2008

Grants

Publications

Cardones, Adela R., Keith M. Sullivan, Cindy Green, Nelson J. Chao, Krista Rowe-Nichols, Lionel L. Bañez, Claude S. Burton, et al. “Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease..” Jama Dermatol 155, no. 7 (July 1, 2019): 833–37. https://doi.org/10.1001/jamadermatol.2018.5459.

PMID
30994873
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Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)..” Biol Blood Marrow Transplant 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.

PMID
30481599
Full Text

Stein-Thoeringer, Christoph K., Jonathan U. Peled, Antonio L. C. Gomes, Amina Lazrak, Melissa D. Docampo, Ann E. Slingerland, Katherine Nichols, et al. “Intestinal Enterococcus Is a Major Risk Factor for the Development of Acute Gvhd.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-119887.

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Khan, Niloufer, Jonathan U. Peled, Antonio Lc Gomes, Sean M. Devlin, Carlos Rondon-Clavo, Annelie Clurman, John B. Slingerland, et al. “Loss of Microbiota Diversity after Autologous Stem Cell Transplant Is Comparable to Injury in Allogeneic Stem Cell Transplant.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-110857.

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Peled, Jonathan U., Antonio L. C. Gomes, Christoph K. Stein-Thoeringer, John B. Slingerland, Ann E. Slingerland, Daniela Weber, Kate A. Markey, et al. “Multicenter Microbiota Analysis Indicates That Pre-HCT Microbiota Injury Is Prevalent across Geography and Predicts Poor Overall Survival.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-116967.

Full Text

Cardona, Diana M., Claire J. Detweiler, Michael J. Shealy, Anthony D. Sung, Daniel M. Wild, Martin H. Poleski, Bryan L. Balmadrid, Constance T. Cirrincione, David N. Howell, and Keith M. Sullivan. “Use of the National Institutes of Health Consensus Guidelines Improves the Diagnostic Sensitivity of Gastrointestinal Graft-Versus-Host Disease..” Arch Pathol Lab Med 142, no. 9 (September 2018): 1098–1105. https://doi.org/10.5858/arpa.2017-0054-OA.

PMID
29697275
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Detweiler, Claire J., Sarah B. Mueller, Anthony D. Sung, Jennifer L. Saullo, Vinod K. Prasad, and Diana M. Cardona. “Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD..” J Pediatr Hematol Oncol 40, no. 6 (August 2018): e364–68. https://doi.org/10.1097/MPH.0000000000001227.

PMID
29846280
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Andermann, Tessa M., Jonathan U. Peled, Christine Ho, Pavan Reddy, Marcie Riches, Rainer Storb, Takanori Teshima, et al. “The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future..” Biol Blood Marrow Transplant 24, no. 7 (July 2018): 1322–40. https://doi.org/10.1016/j.bbmt.2018.02.009.

PMID
29471034
Full Text

Messina, Julia A., Rohita Sinha, Kimberly Starr, Mehreen Arshad, Barbara D. Alexander, Nelson J. Chao, and Anthony D. Sung. “Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia..” Open Forum Infect Dis 5, no. 6 (June 2018). https://doi.org/10.1093/ofid/ofy107.

PMID
29977964
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DeFilipp, Zachariah, Jonathan U. Peled, Shuli Li, Jasmin Mahabamunuge, Zeina Dagher, Ann E. Slingerland, Candice Del Rio, et al. “Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity..” Blood Adv 2, no. 7 (April 10, 2018): 745–53. https://doi.org/10.1182/bloodadvances.2018017731.

PMID
29592876
Full Text

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