Hematologic Malignancies and Cellular Therapy

Anthony D Sung, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Campus mail DUMC Box 3961, Durham, NC 27712
Phone (919) 668-1002
Email address anthony.sung@duke.edu

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

In Their Words

Education and Training

  • Fellowship, Hematology Oncology, Duke University School of Medicine, 2011 - 2014
  • Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, 2008 - 2011
  • M.D., Harvard University , 2008

Grants

Publications

Cardona, DM, Detweiler, CJ, Shealy, MJ, Sung, AD, Wild, DM, Poleski, MH, Balmadrid, BL, Cirrincione, CT, Howell, DN, and Sullivan, KM. "Use of the National Institutes of Health Consensus Guidelines Improves the Diagnostic Sensitivity of Gastrointestinal Graft-Versus-Host Disease." Archives of Pathology & Laboratory Medicine 142, no. 9 (September 2018): 1098-1105.

PMID
29697275
Full Text

Detweiler, CJ, Mueller, SB, Sung, AD, Saullo, JL, Prasad, VK, and Cardona, DM. "Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD." Journal of Pediatric Hematology/Oncology 40, no. 6 (August 2018): e364-e368.

PMID
29846280
Full Text

Andermann, TM, Peled, JU, Ho, C, Reddy, P, Riches, M, Storb, R, Teshima, T, van den Brink, MRM, Alousi, A, Balderman, S, Chiusolo, P, Clark, WB, Holler, E, Howard, A, Kean, LS, Koh, AY, McCarthy, PL, McCarty, JM, Mohty, M, Nakamura, R, Rezvani, K, Segal, BH, Shaw, BE, Shpall, EJ, Sung, AD, Weber, D, Whangbo, J, Wingard, JR, Wood, WA, Perales, M-A, Jenq, RR, Bhatt, AS, and Blood and Marrow Transplant Clinical Trials Network, . "The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 7 (July 2018): 1322-1340.

PMID
29471034
Full Text

O'Sullivan, ML, Shelby, RA, Dorfman, CS, Kelleher, SA, Fisher, HM, Rowe Nichols, KA, Keefe, FJ, Sung, AD, and Somers, TJ. "The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26, no. 4 (April 2018): 1243-1252.

PMID
29124418
Full Text

Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 4 (April 2018): 734-740.

PMID
29246821
Full Text

Peled, JU, Gomes, A, Buchan, ML, Stein-Thoeringer, C, Slingerland, J, Slingerland, AE, Weber, D, Sung, AD, Maloy, M, Peets, T, Gyurkocza, B, Giralt, SA, Jenq, RR, Taur, Y, Xavier, J, Pamer, EG, Chao, NJ, Holler, E, and van den Brink, MRM. "Intestinal Microbiota Injury during Allo-Hct is Generalizable across Transplantation Centers and is Associated with Increased Mortality, Broad-Spectrum Antibiotics, and Decreased Calorie Intake." Blood and Marrow Transplantion Tandem Meetings of the Center-for-International-Blood-and-Marrow-Transplant-Research (CIBMTR) / American-Society-for-Blood-and-Marrow-Transplantation (ASBMT). Salt Lake City, UT. February 21, 2018 - February 25, 2018.: ELSEVIER SCIENCE INC, March 1, 2018.

Scholars@Duke

Guo, M, Chao, NJ, Li, J-Y, Rizzieri, DA, Sun, Q-Y, Mohrbacher, A, Krakow, EF, Sun, W-J, Shen, X-L, Zhan, X-R, Wu, D-P, Liu, L, Wang, J, Zhou, M, Yang, L-H, Bao, Y-Y, Dong, Z, Cai, B, Hu, K-X, Yu, C-L, Qiao, J-H, Zuo, H-L, Huang, Y-J, Sung, AD, Qiao, J-X, Liu, Z-Q, Liu, T-Q, Yao, B, Zhao, H-X, Qian, S-X, Liu, W-W, Forés, R, Duarte, RF, Ai, H-S, and Microtransplantation Interest Group, . "HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia: Results From the Microtransplantation Interest Group." JAMA oncology 4, no. 1 (January 2018): 54-62.

PMID
28910431
Full Text

Anand, S, Thomas, S, Corbet, K, Gasparetto, C, Long, GD, Lopez, R, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Adult Umbilical Cord Blood Transplantation Using Myeloablative Thiotepa, Total Body Irradiation, and Fludarabine Conditioning." November 2017.

PMID
28729147
Full Text

Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157.

PMID
28392378
Full Text

Peled, JU, Devlin, SM, Staffas, A, Lumish, M, Khanin, R, Littmann, ER, Ling, L, Kosuri, S, Maloy, M, Slingerland, JB, Ahr, KF, Porosnicu Rodriguez, KA, Shono, Y, Slingerland, AE, Docampo, MD, Sung, AD, Weber, D, Alousi, AM, Gyurkocza, B, Ponce, DM, Barker, JN, Perales, M-A, Giralt, SA, Taur, Y, Pamer, EG, Jenq, RR, and van den Brink, MRM. "Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 35, no. 15 (May 2017): 1650-1659.

PMID
28296584
Full Text

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