Hematologic Malignancies and Cellular Therapy

Anthony D Sung, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Senior Fellow in the Duke Center for the Study of Aging and Human Development
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address anthony.sung@duke.edu

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

In Their Words

Education and Training

  • Fellowship, Hematology Oncology, Duke University School of Medicine, 2011 - 2014
  • Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, 2008 - 2011
  • M.D., Harvard University , 2008

Grants

Publications

Mishra, Asmita, Jaime M. Preussler, Vijaya Raj Bhatt, Christopher Bredeson, Saurabh Chhabra, Anita D’Souza, Parastoo B. Dahi, et al. “Breaking the Age Barrier: Physicians' Perceptions of Candidacy for Allogeneic Hematopoietic Cell Transplantation in Older Adults.” Transplant Cell Ther 27, no. 7 (July 2021): 617.e1-617.e7. https://doi.org/10.1016/j.jtct.2021.03.028.

PMID
33836312
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Pabon, Cindy M., Zhiguo Li, Therese Hennig, Carlos de Castro, Jadee L. Neff, Mitchell E. Horwitz, Thomas W. LeBlanc, et al. “Morphologic leukemia-free state in acute myeloid leukemia is sufficient for successful allogeneic hematopoietic stem cell transplant.” Blood Cancer J 11, no. 5 (May 16, 2021): 92. https://doi.org/10.1038/s41408-021-00481-9.

PMID
33994546
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Bohannon, Lauren, Helen Tang, Kristin Page, Yi Ren, Sin-Ho Jung, Alexandra Artica, Anne Britt, et al. “Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies.” Transplant Cell Ther, May 12, 2021. https://doi.org/10.1016/j.jtct.2021.05.002.

PMID
33991725
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Giri, Vinay K., Kristin G. Kegerreis, Yi Ren, Lauren M. Bohannon, Erica Lobaugh-Jin, Julia A. Messina, Anita Matthews, et al. “Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.” Transplant Cell Ther 27, no. 3 (March 2021): 262.e1-262.e11. https://doi.org/10.1016/j.jtct.2021.01.004.

PMID
33781532
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Maung, Ko K., Benny J. Chen, Ian Barak, Zhiguo Li, David A. Rizzieri, Cristina Gasparetto, Keith M. Sullivan, et al. “Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation.” Bone Marrow Transplant 56, no. 1 (January 2021): 137–43. https://doi.org/10.1038/s41409-020-0991-5.

PMID
32624583
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Ramalingam, Sendhilnathan, Sharareh Siamakpour-Reihani, Lauren Bohannan, Yi Ren, Alexander Sibley, Jeff Sheng, Li Ma, et al. “A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant.” Plos One 16, no. 6 (2021): e0252995. https://doi.org/10.1371/journal.pone.0252995.

PMID
34170918
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Smith, Patrick, Jillian C. Thompson, Elena Perea, Brian Wasserman, Lauren Bohannon, Alessandro Racioppi, Taewoong Choi, et al. “Clinical and Neuroimaging Correlates of Post-Transplant Delirium.” Biol Blood Marrow Transplant 26, no. 12 (December 2020): 2323–28. https://doi.org/10.1016/j.bbmt.2020.09.016.

PMID
32961373
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Schluter, Jonas, Jonathan U. Peled, Bradford P. Taylor, Kate A. Markey, Melody Smith, Ying Taur, Rene Niehus, et al. “The gut microbiota is associated with immune cell dynamics in humans.” Nature 588, no. 7837 (December 2020): 303–7. https://doi.org/10.1038/s41586-020-2971-8.

PMID
33239790
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Tanaka, John S., Rebecca R. Young, Sarah M. Heston, Kirsten Jenkins, Lisa P. Spees, Anthony D. Sung, Kelly Corbet, et al. “Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.” Biol Blood Marrow Transplant 26, no. 11 (November 2020): 2053–60. https://doi.org/10.1016/j.bbmt.2020.07.011.

PMID
32682948
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Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.” Science 370, no. 6516 (October 30, 2020). https://doi.org/10.1126/science.aay9097.

PMID
33122357
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Pages