Anthony D Sung, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Senior Fellow in the Duke Center for the Study of Aging and Human Development
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address anthony.sung@duke.edu

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

In Their Words

Education and Training

  • Fellowship, Hematology Oncology, Duke University School of Medicine, 2011 - 2014
  • Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, 2008 - 2011
  • M.D., Harvard University , 2008

Publications

Detweiler, Claire J., Sarah B. Mueller, Anthony D. Sung, Jennifer L. Saullo, Vinod K. Prasad, and Diana M. Cardona. “Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD.” J Pediatr Hematol Oncol 40, no. 6 (August 2018): e364–68. https://doi.org/10.1097/MPH.0000000000001227.

PMID
29846280
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Andermann, Tessa M., Jonathan U. Peled, Christine Ho, Pavan Reddy, Marcie Riches, Rainer Storb, Takanori Teshima, et al. “The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future.” Biol Blood Marrow Transplant 24, no. 7 (July 2018): 1322–40. https://doi.org/10.1016/j.bbmt.2018.02.009.

PMID
29471034
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Messina, Julia A., Rohita Sinha, Kimberly Starr, Mehreen Arshad, Barbara D. Alexander, Nelson J. Chao, and Anthony D. Sung. “Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia.” Open Forum Infect Dis 5, no. 6 (June 2018): ofy107. https://doi.org/10.1093/ofid/ofy107.

PMID
29977964
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Wong, Hong Yuen, Anthony Derek Sung, Katherine E. Lindblad, Sheenu Sheela, Gregory W. Roloff, Kristi Romero, Meghali Goswami, et al. “Molecular testing during AML treatment for early prediction of clinical response.” In Journal of Clinical Oncology, 36:7047–7047. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.7047.

Full Text

DeFilipp, Zachariah, Jonathan U. Peled, Shuli Li, Jasmin Mahabamunuge, Zeina Dagher, Ann E. Slingerland, Candice Del Rio, et al. “Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity.” Blood Adv 2, no. 7 (April 10, 2018): 745–53. https://doi.org/10.1182/bloodadvances.2018017731.

PMID
29592876
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O’Sullivan, Madeline L., Rebecca A. Shelby, Caroline S. Dorfman, Sarah A. Kelleher, Hannah M. Fisher, Krista A. Rowe Nichols, Francis J. Keefe, Anthony D. Sung, and Tamara J. Somers. “The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation.” Support Care Cancer 26, no. 4 (April 2018): 1243–52. https://doi.org/10.1007/s00520-017-3947-6.

PMID
29124418
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Sung, Anthony D., Syed Hassan, Diana M. Cardona, Daniel Wild, Krista Rowe Nichols, Hossein Mehdikhani, Bryan Balmadrid, et al. “Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults.” Biol Blood Marrow Transplant 24, no. 4 (April 2018): 734–40. https://doi.org/10.1016/j.bbmt.2017.12.772.

PMID
29246821
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Peled, Jonathan U., Antonio Gomes, Marissa Lubin Buchan, Christoph Stein-Thoeringer, John Slingerland, Ann E. Slingerland, Daniela Weber, et al. “Intestinal Microbiota Injury during Allo-Hct is Generalizable across Transplantation Centers and is Associated with Increased Mortality, Broad-Spectrum Antibiotics, and Decreased Calorie Intake.” In Biology of Blood and Marrow Transplantation, 24:S21–22. ELSEVIER SCIENCE INC, 2018.

Scholars@Duke

Guo, Mei, Nelson J. Chao, Jian-Yong Li, David A. Rizzieri, Qi-Yun Sun, Ann Mohrbacher, Elizabeth F. Krakow, et al. “HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia: Results From the Microtransplantation Interest Group.” Jama Oncol 4, no. 1 (January 1, 2018): 54–62. https://doi.org/10.1001/jamaoncol.2017.2656.

PMID
28910431
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Wong, Hong Yuen, Anthony D. Sung, Katherine E. Lindblad, Sheenu Sheela, Gregory W. Roloff, David Rizzieri, Meghali Goswami, et al. “Molecular Measurable Residual Disease Testing of Blood During AML Cytotoxic Therapy for Early Prediction of Clinical Response.” Front Oncol 8 (2018): 669. https://doi.org/10.3389/fonc.2018.00669.

PMID
30697529
Full Text

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