Bryan David Kraft, MD

Assistant Professor of Medicine
Campus mail Box 3315 DUMC, Durham, NC 27710
Phone (919) 613-6394
Email address bryan.kraft@duke.edu

Dr. Kraft has a wide variety of clinical and research interests, including sepsis, pneumonia, and acute respiratory distress syndrome (ARDS), and has special expertise in rare lung diseases such as pulmonary fibrosis and pulmonary alveolar proteinosis (PAP). PAP can be congenital, hereditary, autoimmune, or due to occupational exposures (e.g. dusts, fibers, silica).

Dr. Kraft performs whole lung lavage (WLL) at Duke in a state-of-the art hyperbaric chamber within the Duke Center for Hyperbaric Medicine and Environmental Physiology. Performing WLL with hyperbaric oxygen (when necessary) augments oxygen delivery during the procedure, meaning both lungs can be lavaged on the same day, during a single episode of anesthesia.

Dr. Kraft’s research laboratory is devoted to understanding mechanisms of acute lung injury resolution, and uses translational models and clinical patient samples to identify novel pathways of recovery. Dr. Kraft is also an active investigator in clinical trials to develop new therapies for patients with lung diseases.

 

Education and Training

  • Fellowship, Pulmonary, Allergy, And Critical Care, Duke University School of Medicine, 2010 - 2013
  • Residency, Internal Medicine, Duke University School of Medicine, 2007 - 2010
  • M.D., University of Tennessee, Memphis, 2007

Publications

Kraft, Bryan D., Lingye Chen, Hagir B. Suliman, Claude A. Piantadosi, and Karen E. Welty-Wolf. “Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis..” Crit Care Med 47, no. 5 (May 2019): 651–58. https://doi.org/10.1097/CCM.0000000000003681.

PMID
30730439
Full Text

Khatri, Aaditya, Bryan D. Kraft, Purushothama Rao Tata, Scott H. Randell, Claude A. Piantadosi, and Ann Marie Pendergast. “ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia..” Proc Natl Acad Sci U S A 116, no. 5 (January 29, 2019): 1603–12. https://doi.org/10.1073/pnas.1816030116.

PMID
30655340
Full Text

Chen, L., B. D. Kraft, V. L. Roggli, H. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Blood Filtration Using Dialysis-Like Therapy Attenuates Organ Injury in Nonhuman Primates with Severe Streptococcus Pneumoniae Sepsis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.

Scholars@Duke

Fredenburgh, Laura E., Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, et al. “A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS..” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.124039.

PMID
30518685
Full Text

Chen, L., B. D. Kraft, V. L. Roggli, H. B. Suliman, C. A. Piantadosi, and K. E. Welty-Wolf. “Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Suliman, Hagir B., Bryan Kraft, Raquel Bartz, Lingye Chen, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice..” Am J Physiol Lung Cell Mol Physiol 313, no. 4 (October 1, 2017): L699–709. https://doi.org/10.1152/ajplung.00197.2017.

PMID
28663335
Full Text

Chen, L., B. D. Kraft, K. Welty-Wolf, H. B. Suhman, and C. Piantadosi. “Peripheral Blood Mononuclear Cells Demonstrate Reversible Mitochondrial Distress In Patients With Sepsis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.

Scholars@Duke

Mahmood, Kamran, Bryan D. Kraft, Kristen Glisinski, Matthew G. Hartwig, Nicole P. Harlan, Claude A. Piantadosi, and Scott L. Shofer. “Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant..” Clin Transplant 30, no. 9 (September 2016): 1134–39. https://doi.org/10.1111/ctr.12798.

PMID
27410718
Full Text

Abril, Maria K., Adam S. Barnett, Kara Wegermann, Eric Fountain, Andrew Strand, Benjamin M. Heyman, Britton A. Blough, et al. “Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing..” Open Forum Infect Dis 3, no. 3 (September 2016). https://doi.org/10.1093/ofid/ofw144.

PMID
27704003
Full Text

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