Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Demchenko, Ivan T., Sergei Yu Zhilyaev, Olga S. Alekseeva, Alexander I. Krivchenko, Claude A. Piantadosi, and Heath G. Gasier. “Increased Antiseizure Effectiveness with Tiagabine Combined with Sodium Channel Antagonists in Mice Exposed to Hyperbaric Oxygen..” Neurotox Res, May 30, 2019. https://doi.org/10.1007/s12640-019-00063-5.

PMID
31148118
Full Text

Kraft, Bryan D., Lingye Chen, Hagir B. Suliman, Claude A. Piantadosi, and Karen E. Welty-Wolf. “Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis..” Crit Care Med 47, no. 5 (May 2019): 651–58. https://doi.org/10.1097/CCM.0000000000003681.

PMID
30730439
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Khatri, Aaditya, Bryan D. Kraft, Purushothama Rao Tata, Scott H. Randell, Claude A. Piantadosi, and Ann Marie Pendergast. “ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia..” Proc Natl Acad Sci U S A 116, no. 5 (January 29, 2019): 1603–12. https://doi.org/10.1073/pnas.1816030116.

PMID
30655340
Full Text

Fredenburgh, Laura E., Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, et al. “A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS..” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.124039.

PMID
30518685
Full Text

Reynolds, James D., Trevor Jenkins, Faisal Matto, Ryan Nazemian, Obada Farhan, Nathan Morris, John M. Longphre, et al. “Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation..” Clin Pharmacol Ther 104, no. 3 (September 2018): 553–63. https://doi.org/10.1002/cpt.979.

PMID
29238951
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Gasier, Heath G., Ivan T. Demchenko, Sergei Yu Zhilyaev, Alexander N. Moskvin, Alexander I. Krivchenko, and Claude A. Piantadosi. “Adrenoceptor blockade modifies regional cerebral blood flow responses to hyperbaric hyperoxia: Protection against CNS oxygen toxicity..” J Appl Physiol (1985), July 19, 2018. https://doi.org/10.1152/japplphysiol.00540.2018.

PMID
30024340
Full Text

Schroeder, Thies, Claude A. Piantadosi, Michael J. Natoli, Julie Autmizguine, Michael Cohen-Wolkowieczs, Karyn L. Hamilton, Christopher Bell, et al. “Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia..” Clin Pharmacol Ther 103, no. 5 (May 2018): 888–98. https://doi.org/10.1002/cpt.860.

PMID
28857147
Full Text

Lin, Li, Chang Xu, Martha S. Carraway, Claude A. Piantadosi, A Richard Whorton, and Sheng Li. “RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling..” Nitric Oxide 74 (April 1, 2018): 56–64. https://doi.org/10.1016/j.niox.2018.01.007.

PMID
29355776
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Spencer, Diane M., John R. Dye, Claude A. Piantadosi, and David S. Pisetsky. “The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro..” Exp Cell Res 363, no. 2 (February 15, 2018): 151–59. https://doi.org/10.1016/j.yexcr.2017.12.024.

PMID
29291399
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Suliman, Hagir B., Bryan Kraft, Raquel Bartz, Lingye Chen, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice..” Am J Physiol Lung Cell Mol Physiol 313, no. 4 (October 1, 2017): L699–709. https://doi.org/10.1152/ajplung.00197.2017.

PMID
28663335
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