Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Spencer, DM, Dye, JR, Piantadosi, CA, and Pisetsky, DS. "The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro." Experimental cell research 363, no. 2 (February 2018): 151-159.

PMID
29291399
Full Text

Lin, L, Xu, C, Carraway, MS, Piantadosi, CA, Whorton, AR, and Li, S. "RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling." Nitric oxide : biology and chemistry 74 (January 18, 2018): 56-64.

PMID
29355776
Full Text

Suliman, HB, Kraft, B, Bartz, R, Chen, L, Welty-Wolf, KE, and Piantadosi, CA. "Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice." American journal of physiology. Lung cellular and molecular physiology 313, no. 4 (October 2017): L699-L709.

PMID
28663335
Full Text

Strand, T-E, Khiabani, HZ, Boico, A, Radiloff, D, Zhao, Y, Hamilton, KL, Christians, U, Klawitter, J, Noveck, RJ, Piantadosi, CA, Bell, C, Irwin, D, and Schroeder, T. "The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans." Canadian journal of physiology and pharmacology 95, no. 9 (September 2017): 1009-1018.

PMID
28467859
Full Text

Schroeder, T, Piantadosi, CA, Natoli, MJ, Autmizguine, J, Cohen-Wolkowieczs, M, Hamilton, KL, Bell, C, Klawitter, J, Christians, U, Irwin, DC, and Noveck, RJ. "Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia." Clinical pharmacology and therapeutics (August 31, 2017).

PMID
28857147
Full Text

Gasier, HG, Demchenko, IT, Tatro, LG, and Piantadosi, CA. "S-nitrosylation of GAD65 is implicated in decreased GAD activity and oxygen-induced seizures." Neuroscience letters 653 (July 2017): 283-287.

PMID
28579483
Full Text

Ghanta, S, Tsoyi, K, Liu, X, Nakahira, K, Ith, B, Coronata, AA, Fredenburgh, LE, Englert, JA, Piantadosi, CA, Choi, AMK, and Perrella, MA. "Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction." American journal of respiratory cell and molecular biology 56, no. 3 (March 2017): 300-309.

PMID
27636016
Full Text

Piantadosi, CA, and Suliman, HB. "Mitochondrial Dysfunction in Lung Pathogenesis." Annual review of physiology 79 (February 2017): 495-515. (Review)

PMID
27959621
Full Text

Demchenko, IT, Zhilyaev, SY, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity." Brain research 1657 (February 2017): 347-354.

PMID
28057450
Full Text

Piantadosi, CA. "Cardioprotective role of S-nitrosylated hemoglobin from rbc." The Journal of clinical investigation 126, no. 12 (December 2016): 4402-4403.

PMID
27841761
Full Text

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