Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Hemal, Kshipra, Neha J. Pagidipati, Adrian Coles, Rowena J. Dolor, Daniel B. Mark, Patricia A. Pellikka, Udo Hoffmann, et al. “Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial..” Jacc Cardiovasc Imaging 9, no. 4 (April 2016): 337–46. https://doi.org/10.1016/j.jcmg.2016.02.001.

PMID
27017234
Full Text

Fordyce, Christopher B., Pamela S. Douglas, Rhonda S. Roberts, Manesh R. Patel, Udo Hoffmann, Daniel B. Mark, Hussein Al-Khalidi, John Kostis, Kerry L. Lee, and James E. Udelson. “IDENTIFYING STABLE CHEST PAIN PATIENTS WITH SUSPECTED CORONARY DISEASE IN WHOM NONINVASIVE TESTING MAY BE SAFELY DEFERRED: INSIGHTS FROM THE PROMISE TRIAL (PROSPECTIVE MULTICENTER IMAGING STUDY FOR EVALUATION OF CHEST PAIN).” In Journal of the American College of Cardiology, 67:2092–2092. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)32093-9.

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Mark, Daniel B., and Christopher M. O’Connor. “When Business and Science Clash, How Can We Avoid Harming Patients?: The Case of AVOID-HF..” Jacc Heart Fail 4, no. 2 (February 2016): 106–8. https://doi.org/10.1016/j.jchf.2015.09.001.

PMID
26519994
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Krishnamoorthy, Arun, Eric D. Peterson, J David Knight, Kevin J. Anstrom, Mark B. Effron, Marjorie E. Zettler, Linda Davidson-Ray, et al. “How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies..” J Am Heart Assoc 5, no. 1 (January 25, 2016). https://doi.org/10.1161/JAHA.115.002695.

PMID
26811163
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Alexander, Karen P., Giora Weisz, Kristi Prather, Stefan James, Daniel B. Mark, Kevin J. Anstrom, Linda Davidson-Ray, et al. “Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial..” Circulation 133, no. 1 (January 5, 2016): 39–47. https://doi.org/10.1161/CIRCULATIONAHA.115.019768.

PMID
26555329
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Au-Yeung, W. T. M., P. G. Reinhall, J. E. Poole, J. Anderson, G. Johnson, R. D. Fletcher, H. J. Moore, D. B. Mark, K. L. Lee, and G. H. Bardy. “Erratum: SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death (HeartRhythm Journal (2015) 12 (2058-2066)).” Heart Rhythm 12, no. 12 (December 1, 2015). https://doi.org/10.1016/j.hrthm.2015.10.032.

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Lu, Michael T., Pamela S. Douglas, James E. Udelson, Elizabeth C. Adami, Brian B. Ghoshhajra, Michael H. Picard, Rhonda Roberts, et al. “Safety of Anatomic versus Functional Diagnostic Testing: Insights From the PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of Chest Pain).” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Au-Yeung, Wan-Tai M., Per G. Reinhall, Jeanne E. Poole, Jill Anderson, George Johnson, Ross D. Fletcher, Hans J. Moore, Daniel B. Mark, Kerry L. Lee, and Gust H. Bardy. “SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death..” Heart Rhythm 12, no. 10 (October 2015): 2058–66. https://doi.org/10.1016/j.hrthm.2015.06.030.

PMID
26096609
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Shah, Rohan, William S. Jones, Louis P. Kohl, Udo Hoffmann, Pamela S. Douglas, Eric Yow, Kerry L. Lee, et al. “TCT-284 Comparison of Visual Assessment of Coronary Stenosis with Independent Quantitative Coronary Angiography: Findings from the PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of chest pain).” In Journal of the American College of Cardiology, 66:B111–12. Elsevier BV, 2015. https://doi.org/10.1016/j.jacc.2015.08.298.

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Hess, Connie N., Mitchell W. Krucoff, Shubin Sheng, Kevin J. Anstrom, W Britt Barham, Ian C. Gilchrist, Robert A. Harrington, et al. “Comparison of quality-of-life measures after radial versus femoral artery access for cardiac catheterization in women: Results of the Study of Access Site for Enhancement of Percutaneous Coronary Intervention for Women quality-of-life substudy..” Am Heart J 170, no. 2 (August 2015): 371–79. https://doi.org/10.1016/j.ahj.2015.04.024.

PMID
26299236
Full Text

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