Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Goehler, A, McMahon, PM, Lumish, HS, Wu, CC, Munshi, V, Gilmore, M, Chung, JH, Ghoshhajra, BB, Mark, D, Truong, QA, Gazelle, GS, and Hoffmann, U. "Cost-effectiveness of follow-up of pulmonary nodules incidentally detected on cardiac computed tomographic angiography in patients with suspected coronary artery disease." Circulation 130, no. 8 (August 2014): 668-675.

PMID
25015342
Full Text

Pun, PH, Al-Khatib, SM, Han, JY, Edwards, R, Bardy, GH, Bigger, JT, Buxton, AE, Moss, AJ, Lee, KL, Steinman, R, Dorian, P, Hallstrom, A, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Hess, PL, Inoue, LYT, and Sanders, GD. "Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in CKD: a meta-analysis of patient-level data from 3 randomized trials." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation 64, no. 1 (July 2014): 32-39.

PMID
24518128
Full Text

Lamas, GA, Boineau, R, Goertz, C, Mark, DB, Rosenberg, Y, Stylianou, M, Rozema, T, Nahin, RL, Terry Chappell, L, Lindblad, L, Lewis, EF, Drisko, J, and Lee, KL. "EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy." American heart journal 168, no. 1 (July 2014): 37-44.e5.

PMID
24952858
Full Text

Mark, DB, Anstrom, KJ, Clapp-Channing, NE, Knight, JD, Boineau, R, Goertz, C, Rozema, TC, Liu, DM, Nahin, RL, Rosenberg, Y, Drisko, J, Lee, KL, Lamas, GA, and TACT Investigators, . "Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the trial to assess chelation therapy randomized trial." Circulation. Cardiovascular Quality and Outcomes 7, no. 4 (July 2014): 508-516.

PMID
24987051
Full Text

Douglas, PS, Hoffmann, U, Lee, KL, Mark, DB, Al-Khalidi, HR, Anstrom, K, Dolor, RJ, Kosinski, A, Krucoff, MW, Mudrick, DW, Patel, MR, Picard, MH, Udelson, JE, Velazquez, EJ, Cooper, L, and PROMISE investigators, . "PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial." American Heart Journal 167, no. 6 (June 2014): 796-803.e1.

PMID
24890527
Full Text

Patton, KK, Hellkamp, AS, Lee, KL, Mark, DB, Johnson, GW, Anderson, J, Bardy, GH, Poole, JE, and SCD-HeFT Investigators, . "Unexpected deviation in circadian variation of ventricular arrhythmias: the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial)." Journal of the American College of Cardiology 63, no. 24 (June 2014): 2702-2708.

PMID
24747100
Full Text

Al-Khatib, SM, Hellkamp, AS, Fonarow, GC, Mark, DB, Curtis, LH, Hernandez, AF, Anstrom, KJ, Peterson, ED, Sanders, GD, Al-Khalidi, HR, Hammill, BG, Heidenreich, PA, and Hammill, SC. "Association between prophylactic implantable cardioverter-defibrillators and survival in patients with left ventricular ejection fraction between 30% and 35%." JAMA 311, no. 21 (June 2014): 2209-2215.

PMID
24893088
Full Text

Anderson, JL, Heidenreich, PA, Barnett, PG, Creager, MA, Fonarow, GC, Gibbons, RJ, Halperin, JL, Hlatky, MA, Jacobs, AK, Mark, DB, Masoudi, FA, Peterson, ED, Shaw, LJ, ACC/AHA Task Force on Performance Measures, , and ACC/AHA Task Force on Practice Guidelines, . "ACC/AHA statement on cost/value methodology in clinical practice guidelines and performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines." Circulation 129, no. 22 (June 2014): 2329-2345.

PMID
24677315
Full Text

Fishbein, DP, Hellkamp, AS, Mark, DB, Walsh, MN, Poole, JE, Anderson, J, Johnson, G, Lee, KL, Bardy, GH, and SCD-HeFT Investigators, . "Use of the 6-min walk distance to identify variations in treatment benefits from implantable cardioverter-defibrillator and amiodarone: results from the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial)." Journal of the American College of Cardiology 63, no. 23 (June 2014): 2560-2568.

PMID
24727258
Full Text

Anderson, JL, Heidenreich, PA, Barnett, PG, Creager, MA, Fonarow, GC, Gibbons, RJ, Halperin, JL, Hlatky, MA, Jacobs, AK, Mark, DB, Masoudi, FA, Peterson, ED, and Shaw, LJ. "ACC/AHA statement on cost/value methodology in clinical practice guidelines and performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines." Journal of the American College of Cardiology 63, no. 21 (June 2014): 2304-2322.

PMID
24681044
Full Text

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