Daniel Christopher Parker, MD

Medical Instructor in the Department of Medicine
Campus mail Rm 1510 Blue Zone Duke South, Box 3003, Durham, NC 27705
Phone (919) 660-7692
Email address daniel.parker@duke.edu

Biological aging is the greatest risk factor for most chronic diseases, including frailty and dementia. The geroscience hypothesis posits that interventions that target aspects of biological aging may delay or prevent many of these diseases simultaneously. My research centers on understanding the mechanisms of interventions that affect biological aging, like exercise training and caloric restriction and using that understanding to develop therapies that maintain cognitive and physical function in older adults.

Education and Training

  • Post-Doctoral Research Fellowship, Duke Center For The Study Of Aging And Human Development, Duke University School of Medicine, 2017 - 2019
  • Internal Medicine Residency, Eastern Virginia Medical School, 2013 - 2016
  • Advanced Fellowship in Geriatric Medicine, Medicine, -, 0018
  • M.D., Eastern Virginia Medical School, 2013
Weight
-20

Publications

Colón-Emeric, Cathleen, Heather E. Whitson, Carl F. Pieper, Richard Sloane, Denise Orwig, Kim M. Huffman, Janet Prvu Bettger, et al. “Resiliency Groups Following Hip Fracture in Older Adults..” J Am Geriatr Soc 67, no. 12 (December 2019): 2519–27. https://doi.org/10.1111/jgs.16152.

PMID
31469411
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Parker, Daniel C., Bryce N. Bartlett, Harvey J. Cohen, Gerda Fillenbaum, Janet L. Huebner, Virginia Byers Kraus, Carl Pieper, and Daniel W. Belsky. “Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults..” J Gerontol a Biol Sci Med Sci, November 6, 2019. https://doi.org/10.1093/gerona/glz219.

PMID
31693736
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Zhou, Jin, Daniel C. Parker, James P. White, Andrea Lim, Kim M. Huffman, Jia Pei Ho, Paul M. Yen, and William E. Kraus. “Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation..” Front Physiol 10 (2019). https://doi.org/10.3389/fphys.2019.01363.

PMID
31736784
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Parker, Daniel C., Michelle M. Mielke, Qilu Yu, Paul B. Rosenberg, Alka Jain, Constantine G. Lyketsos, Neal S. Fedarko, and Esther S. Oh. “Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease.” International Journal of Geriatric Psychiatry 28, no. 2 (February 2013): 149–54. https://doi.org/10.1002/gps.3802.

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Archin, N. M., A. L. Liberty, A. D. Kashuba, S. K. Choudhary, J. D. Kuruc, A. M. Crooks, D. C. Parker, et al. “Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.” Nature 487, no. 7408 (July 2012): 482–85. https://doi.org/10.1038/nature11286.

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Anderson, J. A., N. M. Archin, W. Ince, D. Parker, A. Wiegand, J. M. Coffin, J. Kuruc, J. Eron, R. Swanstrom, and D. M. Margolis. “Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells.” Journal of Virology 85, no. 10 (May 15, 2011): 5220–23. https://doi.org/10.1128/jvi.00284-11.

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Levesque, Marc C., M Anthony Moody, Kwan-Ki Hwang, Dawn J. Marshall, John F. Whitesides, Joshua D. Amos, Thaddeus C. Gurley, et al. “Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection..” Plos Med 6, no. 7 (July 7, 2009). https://doi.org/10.1371/journal.pmed.1000107.

PMID
19582166
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Archin, Nancie M., Amy Espeseth, Daniel Parker, Manzoor Cheema, Daria Hazuda, and David M. Margolis. “Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid.” Aids Research and Human Retroviruses 25, no. 2 (February 2009): 207–12. https://doi.org/10.1089/aid.2008.0191.

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Archin, Nancie M., Manzoor Cheema, Daniel Parker, Ann Wiegand, Ronald J. Bosch, John M. Coffin, Joseph Eron, Myron Cohen, and David M. Margolis. “Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection.” Plos One 5, no. 2 (n.d.): e9390–e9390. https://doi.org/10.1371/journal.pone.0009390.

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