Daniel John Sexton, MD

Professor of Medicine
Campus mail Duke Box 102359, Durham, NC 27710
Phone (919) 684-4596
Email address sexto002@mc.duke.edu

During the past 8 years my research interests have changed from a focus on tick-borne disease and endocarditis to a primary focus on healthcare-associated infections (HAIs). Specifically, I have been interested in HAIs in community hospitals. Using prospective data collected as part of our surveillance activities in the Duke Infection Control Outreach Network (DICON), I and my colleagues have focused on these specific areas of research:

• The accuracy and reliability of surveillance definitions used to document and trend rates of HAIs
• Outcomes of HAIs (both financial and clinical) with particular emphasis on bloodstream and surgical site infections
• Trends in HAIs due to pathogens resistant to common antimicrobial agents
• Temporal and geographic variations in the occurrence of pathogens such as methicillin-resistant S. aureus, E coli and Klebsiella pneumonia
• The prevention and control of HAIs with particular emphasis on the potential role of the environment in the transmission of HAIs

As the principal investigator on one of the 5 national epicenter grants funded by the Centers for Disease control I, along with my co-investigators from the Duke and University of North Carolina Division of Infectious Disease, are involved in a 5-year prospective study of the potential benefit of enhanced cleaning methods (such as the use of ultraviolet light emitters) in the prevention of HAIs. This study involves 9 hospitals in North Carolina and Virginia and will include a trial of 4 different cleaning methods utilized sequentially but randomly in these study hospitals over a 28-month time period. Additionally the Duke Epicenter is also undertaking prospective trials investigating the utility and reliability of new (streamlined) definitions of ventilator-associated pneumonia.

Key words that characterize my work: surgical site infections and nosocomial infections.

Education and Training

  • Internship, General Medicine, Mount Sinai School of Medicine, 1971 - 1972
  • Residency, General Internal Medicine, University of Missouri - Columbia School of Medicine, 1197
  • Fellowship, Infectious Diseases, Duke University School of Medicine, 1197
  • M.D., Northwestern University, 1971

Publications

Dicks, KV, Lofgren, E, Lewis, SS, Moehring, RW, Sexton, DJ, and Anderson, DJ. "A Multicenter Pragmatic Interrupted Time Series Analysis of Chlorhexidine Gluconate Bathing in Community Hospital Intensive Care Units." Infection control and hospital epidemiology 37, no. 7 (July 2016): 791-797.

PMID
26861417
Full Text

Baker, AW, Dicks, KV, Durkin, MJ, Weber, DJ, Lewis, SS, Moehring, RW, Chen, LF, Sexton, DJ, and Anderson, DJ. "Epidemiology of Surgical Site Infection in a Community Hospital Network." Infection control and hospital epidemiology 37, no. 5 (May 2016): 519-526.

PMID
26864617
Full Text

Dicks, KV, Baker, AW, Durkin, MJ, Anderson, DJ, Moehring, RW, Chen, LF, Sexton, DJ, Weber, DJ, and Lewis, SS. "Short Operative Duration and Surgical Site Infection Risk in Hip and Knee Arthroplasty Procedures." Infection control and hospital epidemiology 36, no. 12 (December 2015): 1431-1436.

PMID
26391277
Full Text

Durkin, MJ, Dicks, KV, Baker, AW, Lewis, SS, Moehring, RW, Chen, LF, Sexton, DJ, and Anderson, DJ. "Seasonal Variation of Common Surgical Site Infections: Does Season Matter?." Infection control and hospital epidemiology 36, no. 9 (September 2015): 1011-1016.

PMID
26008876
Full Text

Moehring, RW, Hazen, KC, Hawkins, MR, Drew, RH, Sexton, DJ, and Anderson, DJ. "Challenges in Preparation of Cumulative Antibiogram Reports for Community Hospitals." Journal of clinical microbiology 53, no. 9 (September 2015): 2977-2982.

PMID
26179303
Full Text

Durkin, MJ, Dicks, KV, Baker, AW, Moehring, RW, Chen, LF, Sexton, DJ, Lewis, SS, and Anderson, DJ. "Postoperative infection in spine surgery: does the month matter?." Journal of neurosurgery. Spine 23, no. 1 (July 2015): 128-134.

PMID
25860519
Full Text

Dicks, KV, Baker, AW, Durkin, MJ, Lewis, SS, Moehring, RW, Anderson, DJ, Sexton, DJ, and Chen, LF. "The potential impact of excluding funguria from the surveillance definition of catheter-associated urinary tract infection." Infection control and hospital epidemiology 36, no. 4 (April 2015): 467-469.

PMID
25782903
Full Text

Lewis, SS, Dicks, KV, Chen, LF, Bolognesi, MP, Anderson, DJ, Sexton, DJ, and Moehring, RW. "Delay in diagnosis of invasive surgical site infections following knee arthroplasty versus hip arthroplasty." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 60, no. 7 (April 2015): 990-996.

PMID
25501986
Full Text

Arnold, CJ, Johnson, M, Bayer, AS, Bradley, S, Giannitsioti, E, Miró, JM, Tornos, P, Tattevin, P, Strahilevitz, J, Spelman, D, Athan, E, Nacinovich, F, Fortes, CQ, Lamas, C, Barsic, B, Fernández-Hidalgo, N, Muñoz, P, and Chu, VH. "Candida infective endocarditis: an observational cohort study with a focus on therapy." Antimicrobial agents and chemotherapy 59, no. 4 (April 2015): 2365-2373.

PMID
25645855
Full Text

Chirouze, C, Alla, F, Fowler, VG, Sexton, DJ, Corey, GR, Chu, VH, Wang, A, Erpelding, M-L, Durante-Mangoni, E, Fernández-Hidalgo, N, Giannitsioti, E, Hannan, MM, Lejko-Zupanc, T, Miró, JM, Muñoz, P, Murdoch, DR, Tattevin, P, Tribouilloy, C, Hoen, B, and ICE Prospective Investigators, . "Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 60, no. 5 (March 2015): 741-749.

PMID
25389255
Full Text

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