Daniel John Sexton, MD

Professor of Medicine
Campus mail Duke Box 102359, Durham, NC 27710
Phone (919) 684-4596
Email address sexto002@mc.duke.edu

During the past 8 years my research interests have changed from a focus on tick-borne disease and endocarditis to a primary focus on healthcare-associated infections (HAIs). Specifically, I have been interested in HAIs in community hospitals. Using prospective data collected as part of our surveillance activities in the Duke Infection Control Outreach Network (DICON), I and my colleagues have focused on these specific areas of research:

• The accuracy and reliability of surveillance definitions used to document and trend rates of HAIs
• Outcomes of HAIs (both financial and clinical) with particular emphasis on bloodstream and surgical site infections
• Trends in HAIs due to pathogens resistant to common antimicrobial agents
• Temporal and geographic variations in the occurrence of pathogens such as methicillin-resistant S. aureus, E coli and Klebsiella pneumonia
• The prevention and control of HAIs with particular emphasis on the potential role of the environment in the transmission of HAIs

As the principal investigator on one of the 5 national epicenter grants funded by the Centers for Disease control I, along with my co-investigators from the Duke and University of North Carolina Division of Infectious Disease, are involved in a 5-year prospective study of the potential benefit of enhanced cleaning methods (such as the use of ultraviolet light emitters) in the prevention of HAIs. This study involves 9 hospitals in North Carolina and Virginia and will include a trial of 4 different cleaning methods utilized sequentially but randomly in these study hospitals over a 28-month time period. Additionally the Duke Epicenter is also undertaking prospective trials investigating the utility and reliability of new (streamlined) definitions of ventilator-associated pneumonia.

Key words that characterize my work: surgical site infections and nosocomial infections.

Education and Training

  • Internship, General Medicine, Icahn School of Medicine at Mount Sinai, 1971 - 1972
  • Residency, General Internal Medicine, University of Missouri - Columbia School of Medicine, 0018
  • Fellowship, Infectious Diseases, Duke University School of Medicine, 0018
  • M.D., Northwestern University, 1971

Publications

Chen, Luke F., Lauren P. Knelson, Maria F. Gergen, Olga M. Better, Bradly P. Nicholson, Christopher W. Woods, William A. Rutala, et al. “A prospective study of transmission of Multidrug-Resistant Organisms (MDROs) between environmental sites and hospitalized patients-the TransFER study..” Infect Control Hosp Epidemiol 40, no. 1 (January 2019): 47–52. https://doi.org/10.1017/ice.2018.275.

PMID
30426908
Full Text

Seidelman, Jessica, Arthur W. Baker, Deverick J. Anderson, Daniel J. Sexton, and Sarah S. Lewis. “Do Periarticular Joint Infections Present an Increase in Infection Risk?.” Infect Control Hosp Epidemiol 39, no. 7 (July 2018): 890–91. https://doi.org/10.1017/ice.2018.80.

PMID
29655381
Full Text

Hostler, Christopher J., Rebekah W. Moehring, Elizabeth S Dodds Ashley, Melissa Johnson, Angelina Davis, Sarah S. Lewis, Daniel J. Sexton, Deverick J. Anderson, and Deverick J. CDC Prevention Epicenters Program. “Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals..” Infect Control Hosp Epidemiol 39, no. 6 (June 2018): 718–22. https://doi.org/10.1017/ice.2018.71.

PMID
29681253
Full Text

Dicks, Kristen V., Eric Lofgren, Sarah S. Lewis, Rebekah W. Moehring, Daniel J. Sexton, and Deverick J. Anderson. “A Multicenter Pragmatic Interrupted Time Series Analysis of Chlorhexidine Gluconate Bathing in Community Hospital Intensive Care Units..” Infect Control Hosp Epidemiol 37, no. 7 (July 2016): 791–97. https://doi.org/10.1017/ice.2016.23.

PMID
26861417
Full Text

Baker, Arthur W., Kristen V. Dicks, Michael J. Durkin, David J. Weber, Sarah S. Lewis, Rebekah W. Moehring, Luke F. Chen, Daniel J. Sexton, and Deverick J. Anderson. “Epidemiology of Surgical Site Infection in a Community Hospital Network..” Infect Control Hosp Epidemiol 37, no. 5 (May 2016): 519–26. https://doi.org/10.1017/ice.2016.13.

PMID
26864617
Full Text

Dicks, Kristen V., Arthur W. Baker, Michael J. Durkin, Deverick J. Anderson, Rebekah W. Moehring, Luke F. Chen, Daniel J. Sexton, David J. Weber, and Sarah S. Lewis. “Short Operative Duration and Surgical Site Infection Risk in Hip and Knee Arthroplasty Procedures..” Infect Control Hosp Epidemiol 36, no. 12 (December 2015): 1431–36. https://doi.org/10.1017/ice.2015.222.

PMID
26391277
Full Text

Durkin, Michael J., Kristen V. Dicks, Arthur W. Baker, Sarah S. Lewis, Rebekah W. Moehring, Luke F. Chen, Daniel J. Sexton, and Deverick J. Anderson. “Seasonal Variation of Common Surgical Site Infections: Does Season Matter?.” Infect Control Hosp Epidemiol 36, no. 9 (September 2015): 1011–16. https://doi.org/10.1017/ice.2015.121.

PMID
26008876
Full Text

Moehring, Rebekah W., Kevin C. Hazen, Myra R. Hawkins, Richard H. Drew, Daniel J. Sexton, and Deverick J. Anderson. “Challenges in Preparation of Cumulative Antibiogram Reports for Community Hospitals..” J Clin Microbiol 53, no. 9 (September 2015): 2977–82. https://doi.org/10.1128/JCM.01077-15.

PMID
26179303
Full Text

Durkin, Michael J., Kristen V. Dicks, Arthur W. Baker, Rebekah W. Moehring, Luke F. Chen, Daniel J. Sexton, Sarah S. Lewis, and Deverick J. Anderson. “Postoperative infection in spine surgery: does the month matter?.” J Neurosurg Spine 23, no. 1 (July 2015): 128–34. https://doi.org/10.3171/2014.10.SPINE14559.

PMID
25860519
Full Text

Pages