Daniel John Sexton, MD

Professor of Medicine
Campus mail Duke Box 102359, Durham, NC 27710
Phone (919) 684-4596
Email address sexto002@mc.duke.edu

During the past 8 years my research interests have changed from a focus on tick-borne disease and endocarditis to a primary focus on healthcare-associated infections (HAIs). Specifically, I have been interested in HAIs in community hospitals. Using prospective data collected as part of our surveillance activities in the Duke Infection Control Outreach Network (DICON), I and my colleagues have focused on these specific areas of research:

• The accuracy and reliability of surveillance definitions used to document and trend rates of HAIs
• Outcomes of HAIs (both financial and clinical) with particular emphasis on bloodstream and surgical site infections
• Trends in HAIs due to pathogens resistant to common antimicrobial agents
• Temporal and geographic variations in the occurrence of pathogens such as methicillin-resistant S. aureus, E coli and Klebsiella pneumonia
• The prevention and control of HAIs with particular emphasis on the potential role of the environment in the transmission of HAIs

As the principal investigator on one of the 5 national epicenter grants funded by the Centers for Disease control I, along with my co-investigators from the Duke and University of North Carolina Division of Infectious Disease, are involved in a 5-year prospective study of the potential benefit of enhanced cleaning methods (such as the use of ultraviolet light emitters) in the prevention of HAIs. This study involves 9 hospitals in North Carolina and Virginia and will include a trial of 4 different cleaning methods utilized sequentially but randomly in these study hospitals over a 28-month time period. Additionally the Duke Epicenter is also undertaking prospective trials investigating the utility and reliability of new (streamlined) definitions of ventilator-associated pneumonia.

Key words that characterize my work: surgical site infections and nosocomial infections.

Education and Training

  • Internship, General Medicine, Icahn School of Medicine at Mount Sinai, 1971 - 1972
  • Residency, General Internal Medicine, University of Missouri - Columbia School of Medicine, 0018
  • Fellowship, Infectious Diseases, Duke University School of Medicine, 0018
  • M.D., Northwestern University, 1971

Publications

Doern, Gary V., Karen C. Carroll, Daniel J. Diekema, Kevin W. Garey, Mark E. Rupp, Melvin P. Weinstein, and Daniel J. Sexton. “A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem..” Clin Microbiol Rev 33, no. 1 (December 18, 2019). https://doi.org/10.1128/CMR.00009-19.

PMID
31666280
Full Text

Rutala, William A., Hajime Kanamori, Maria F. Gergen, Emily E. Sickbert-Bennett, Deverick J. Anderson, Daniel J. Sexton, David J. Weber, and David J. CDC Prevention Epicenters Program. “Evaluation of dilute hydrogen peroxide technology for continuous room decontamination of multidrug-resistant organisms..” Infect Control Hosp Epidemiol 40, no. 12 (December 2019): 1438–39. https://doi.org/10.1017/ice.2019.261.

PMID
31576788
Full Text

Seidelman, Jessica L., Becky Smith, Brittain Wood, Linda Adcock, Barry Shelton, Kirk Huslage, Art Baker, et al. “Shifting surgical site infection denominators and implications for National Health Safety Network reporting..” Infect Control Hosp Epidemiol 40, no. 11 (November 2019): 1316–17. https://doi.org/10.1017/ice.2019.255.

PMID
31474233
Full Text

Yarrington, Michael E., Deverick J. Anderson, Elizabeth Dodds Ashley, Travis Jones, Angelina Davis, Melissa Johnson, Yuliya Lokhnygina, Daniel J. Sexton, and Rebekah W. Moehring. “Impact of FDA black box warning on fluoroquinolone and alternative antibiotic use in southeastern US hospitals..” Infect Control Hosp Epidemiol 40, no. 11 (November 2019): 1297–1300. https://doi.org/10.1017/ice.2019.247.

PMID
31474240
Full Text

Seidelman, Jessica L., Becky Smith, Christopher Shoff, Arthur W. Baker, Sarah S. Lewis, Deverick J. Anderson, and Daniel J. Sexton. “Serious superficial incisional surgical site infections (SSISSIs): A proposed surveillance definition..” Infect Control Hosp Epidemiol 40, no. 11 (November 2019): 1258–59. https://doi.org/10.1017/ice.2019.174.

PMID
31625493
Full Text

Anderson, Deverick J., Shera Watson, Rebekah W. Moehring, Lauren Komarow, Matthew Finnemeyer, Rebekka M. Arias, Jacqueline Huvane, et al. “Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals..” Jama Netw Open 2, no. 8 (August 2, 2019). https://doi.org/10.1001/jamanetworkopen.2019.9369.

PMID
31418804
Full Text

McClain, Micah T., and Daniel J. Sexton. “Surveillance for Spotted Fever Group Rickettsial Infections: Problems, Pitfalls and Potential Solutions..” J Infect Dis, July 3, 2019. https://doi.org/10.1093/infdis/jiz317.

PMID
31267127
Full Text

Chen, Luke F., Lauren P. Knelson, Maria F. Gergen, Olga M. Better, Bradly P. Nicholson, Christopher W. Woods, William A. Rutala, et al. “A prospective study of transmission of Multidrug-Resistant Organisms (MDROs) between environmental sites and hospitalized patients-the TransFER study..” Infect Control Hosp Epidemiol 40, no. 1 (January 2019): 47–52. https://doi.org/10.1017/ice.2018.275.

PMID
30426908
Full Text

Rutala, William A., Hajime Kanamori, Maria F. Gergen, Emily E. Sickbert-Bennett, Daniel J. Sexton, Deverick J. Anderson, Jeffrey Laux, David J. Weber, and David J. CDC Prevention Epicenters Program. “Antimicrobial activity of a continuous visible light disinfection system..” Infect Control Hosp Epidemiol 39, no. 10 (October 2018): 1250–53. https://doi.org/10.1017/ice.2018.200.

PMID
30160225
Full Text

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