Dennis M Abraham, MD

Assistant Professor of Medicine
Campus mail Dept of Medicine, Box 31039, Durham, NC 27710
Phone (919) 684-8111
Email address dennis.abraham@duke.edu
In Their Words

Education and Training

  • Resident, Internal Medicine, Icahn School of Medicine at Mount Sinai, 2003 - 2005
  • Intern, Internal Medicine, Icahn School of Medicine at Mount Sinai, 2002 - 2003
  • M.D., Thomas Jefferson University, 2002

Publications

Yu, Samuel Mon-Wei, Pierre-Yves Jean-Charles, Dennis M. Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A. Rockman, and Sudha K. Shenoy. “The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling..” J Biol Chem 294, no. 7 (February 15, 2019): 2500–2518. https://doi.org/10.1074/jbc.RA118.004926.

PMID
30538132
Full Text

Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction..” The Journal of Clinical Investigation 128, no. 11 (November 2018): 4843–55. https://doi.org/10.1172/JCI95945.

PMID
30153110
Full Text

Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload..” The Journal of Biological Chemistry 293, no. 27 (July 2018): 10630–45. https://doi.org/10.1074/jbc.ra118.002187.

PMID
29769314
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Toth, Krisztian, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter Boone, Lan Mao, Dennis Abraham, Marc G. Caron, and Lawrence S. Barak. “Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2..” Synapse (New York, N.Y.) 72, no. 1 (January 2018). https://doi.org/10.1002/syn.22012.

PMID
28941296
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Hershberger, Kathleen A., Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, and Matthew D. Hirschey. “Sirtuin 5 is required for mouse survival in response to cardiac pressure overload..” The Journal of Biological Chemistry 292, no. 48 (December 2017): 19767–81. https://doi.org/10.1074/jbc.M117.809897.

PMID
28972174
Full Text

Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, et al. “Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling..” Jci Insight 2, no. 17 (September 7, 2017). https://doi.org/10.1172/jci.insight.95998.

PMID
28878120
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Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model..” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.

PMID
28724806
Full Text

Abraham, Dennis M., Robert T. Davis, Chad M. Warren, Lan Mao, Beata M. Wolska, R John Solaro, and Howard A. Rockman. “β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility..” Proceedings of the National Academy of Sciences of the United States of America 113, no. 50 (December 2016): 14426–31. https://doi.org/10.1073/pnas.1609308113.

PMID
27911784
Full Text

Torok, Rachel D., Dennis M. Abraham, Clarice Gareri, Lan Mao, and Howard A. Rockman. “TWIK-Related Acid-Sensitive K+ Channels Affect the Development of Aortic Root Aneurysms in Mice.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.

Scholars@Duke

Abraham, Dennis, and Lan Mao. “Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice..” Journal of Visualized Experiments : Jove, no. 103 (September 17, 2015). https://doi.org/10.3791/52942.

PMID
26436838
Full Text

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