Derek Wilson Cain, PhD

Associate Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710
Phone (919) 681-8193

My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.

Education and Training

  • Ph.D., Duke University, 2010

Publications

Li, Dapeng, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, et al. “Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.” Commun Biol 5, no. 1 (March 28, 2022): 271. https://doi.org/10.1038/s42003-022-03183-5.

PMID
35347236
Full Text

Mu, Zekun, Kevin Wiehe, Kevin O. Saunders, Rory Henderson, Derek W. Cain, Robert Parks, Diana Martik, et al. “mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.” Cell Rep 38, no. 11 (March 15, 2022): 110514. https://doi.org/10.1016/j.celrep.2022.110514.

PMID
35294883
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Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.” Curr Opin Virol 51 (December 2021): 172–78. https://doi.org/10.1016/j.coviro.2021.09.015.

PMID
34742037
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Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.

PMID
34242577
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Fries, Chelsea N., Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, et al. “HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.” Sci Rep 11, no. 1 (July 14, 2021): 14494. https://doi.org/10.1038/s41598-021-93702-x.

PMID
34262096
Full Text

Cain, Derek W., Carl D. Bortner, David Diaz-Jimenez, Maria G. Petrillo, Amanda Gruver-Yates, and John A. Cidlowski. “Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.” J Immunol 205, no. 3 (August 1, 2020): 619–29. https://doi.org/10.4049/jimmunol.1901135.

PMID
32571841
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Tian, Ming, Kelly McGovern, Hwei-Ling Cheng, Peyton Waddicor, Lisa Rieble, Mai Dao, Yiwei Chen, et al. “Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.” Proc Natl Acad Sci U S A 117, no. 14 (April 7, 2020): 7929–40. https://doi.org/10.1073/pnas.1921996117.

PMID
32209668
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Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.

PMID
32075963
Full Text

Pages