Derek Wilson Cain, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710
Phone (919) 681-8193

My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.

Education and Training

  • Ph.D., Duke University, 2010

Publications

Cain, DW, and Cidlowski, JA. "Immune regulation by glucocorticoids." Nature Reviews Immunology 17, no. 4 (February 13, 2017): 233-247.

Full Text

Abbott, RK, Silva, M, Labuda, J, Thayer, M, Cain, DW, Philbrook, P, Sethumadhavan, S, Hatfield, S, Ohta, A, and Sitkovsky, M. "The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center." The Journal of biological chemistry 292, no. 4 (January 2017): 1211-1217.

PMID
27974461
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Abbott, RK, Thayer, M, Labuda, J, Silva, M, Philbrook, P, Cain, DW, Kojima, H, Hatfield, S, Sethumadhavan, S, Ohta, A, Reinherz, EL, Kelsoe, G, and Sitkovsky, M. "Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination." Journal of immunology (Baltimore, Md. : 1950) 197, no. 10 (November 2016): 4014-4020.

PMID
27798169
Full Text

Cain, DW, O'Koren, EG, Kan, MJ, Womble, M, Sempowski, GD, Hopper, K, Gunn, MD, and Kelsoe, G. "Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages." J Immunol 191, no. 9 (November 1, 2013): 4665-4675.

PMID
24078688
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Yang, G, Holl, TM, Liu, Y, Li, Y, Lu, X, Nicely, NI, Kepler, TB, Alam, SM, Liao, H-X, Cain, DW, Spicer, L, VandeBerg, JL, Haynes, BF, and Kelsoe, G. "Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies." The Journal of experimental medicine 210, no. 2 (February 2013): 241-256.

PMID
23359068
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Kim, M, Song, L, Moon, J, Sun, Z-YJ, Bershteyn, A, Hanson, M, Cain, D, Goka, S, Kelsoe, G, Wagner, G, and al, E. "Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry." Journal of Biological Chemistry 288, no. 44 (2013): 31888-31901.

PMID
24047898
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Cain, DW, Sanders, SE, Cunningham, MM, and Kelsoe, G. "Disparate adjuvant properties among three formulations of "alum"." Vaccine (2012).

PMID
23200935
Full Text

Cain, DW, and Gunn, MD. "NUR who? An orphan transcription factor holds promise for monomaniacs. (Published online)" Nat Immunol 12, no. 8 (July 19, 2011): 727-729.

PMID
21772283
Full Text

Kuraoka, M, Holl, TM, Liao, D, Womble, M, Cain, DW, Reynolds, AE, and Kelsoe, G. "Activation-induced cytidine deaminase mediates central tolerance in B cells." Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11560-11565.

PMID
21700885
Full Text

Cain, DW, Snowden, PB, Sempowski, GD, and Kelsoe, G. "Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism." PLoS One 6, no. 5 (2011): e19957-.

PMID
21655273
Full Text

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