Derek Wilson Cain, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710
Phone (919) 681-8193

My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.

Education and Training

  • Ph.D., Duke University, 2010

Grants

Publications

Bradley, T, Peppa, D, Pedroza-Pacheco, I, Li, D, Cain, DW, Henao, R, Venkat, V, Hora, B, Chen, Y, Vandergrift, NA, Overman, RG, Edwards, RW, Woods, CW, Tomaras, GD, Ferrari, G, Ginsburg, GS, Connors, M, Cohen, MS, Moody, MA, Borrow, P, and Haynes, BF. "RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses." Cell 175, no. 2 (October 2018): 387-399.e17.

PMID
30270043
Full Text

Pardi, N, Hogan, MJ, Naradikian, MS, Parkhouse, K, Cain, DW, Jones, L, Moody, MA, Verkerke, HP, Myles, A, Willis, E, LaBranche, CC, Montefiori, DC, Lobby, JL, Saunders, KO, Liao, H-X, Korber, BT, Sutherland, LL, Scearce, RM, Hraber, PT, Tombácz, I, Muramatsu, H, Ni, H, Balikov, DA, Li, C, Mui, BL, Tam, YK, Krammer, F, Karikó, K, Polacino, P, Eisenlohr, LC, Madden, TD, Hope, MJ, Lewis, MG, Lee, KK, Hu, S-L, Hensley, SE, Cancro, MP, Haynes, BF, and Weissman, D. "Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses." The Journal of Experimental Medicine 215, no. 6 (June 2018): 1571-1588.

PMID
29739835
Full Text

Saunders, KO, Verkoczy, LK, Jiang, C, Zhang, J, Parks, R, Chen, H, Housman, M, Bouton-Verville, H, Shen, X, Trama, AM, Scearce, R, Sutherland, L, Santra, S, Newman, A, Eaton, A, Xu, K, Georgiev, IS, Joyce, MG, Tomaras, GD, Bonsignori, M, Reed, SG, Salazar, A, Mascola, JR, Moody, MA, Cain, DW, Centlivre, M, Zurawski, S, Zurawski, G, Erickson, HP, Kwong, PD, Alam, SM, Levy, Y, Montefiori, DC, and Haynes, BF. "Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models." Cell Reports 21, no. 13 (December 2017): 3681-3690.

PMID
29281818
Full Text

Cain, DW, and Cidlowski, JA. "Immune regulation by glucocorticoids." Nature Reviews. Immunology 17, no. 4 (April 2017): 233-247. (Review)

PMID
28192415
Full Text

Abbott, RK, Silva, M, Labuda, J, Thayer, M, Cain, DW, Philbrook, P, Sethumadhavan, S, Hatfield, S, Ohta, A, and Sitkovsky, M. "The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center." The Journal of biological chemistry 292, no. 4 (January 2017): 1211-1217.

PMID
27974461
Full Text

Abbott, RK, Thayer, M, Labuda, J, Silva, M, Philbrook, P, Cain, DW, Kojima, H, Hatfield, S, Sethumadhavan, S, Ohta, A, Reinherz, EL, Kelsoe, G, and Sitkovsky, M. "Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination." Journal of Immunology (Baltimore, Md. : 1950) 197, no. 10 (November 2016): 4014-4020.

PMID
27798169
Full Text

Bortner, CD, Scoltock, AB, Cain, DW, and Cidlowski, JA. "T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways." Cell death and differentiation 23, no. 5 (May 2016): 889-902.

PMID
26658018
Full Text

Cain, DW, and Cidlowski, JA. "Specificity and sensitivity of glucocorticoid signaling in health and disease." Best practice & research. Clinical endocrinology & metabolism 29, no. 4 (August 2015): 545-556. (Review)

PMID
26303082
Full Text

Cain, DW, O'Koren, EG, Kan, MJ, Womble, M, Sempowski, GD, Hopper, K, Gunn, MD, and Kelsoe, G. "Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages." J Immunol 191, no. 9 (November 1, 2013): 4665-4675.

PMID
24078688
Full Text

Kim, M, Song, L, Moon, J, Sun, Z-YJ, Bershteyn, A, Hanson, M, Cain, D, Goka, S, Kelsoe, G, Wagner, G, Irvine, D, and Reinherz, EL. "Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry." The Journal of Biological Chemistry 288, no. 44 (November 2013): 31888-31901.

PMID
24047898
Full Text

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