Derek Wilson Cain, PhD

Assistant Professor in Medicine

Member of the Duke Human Vaccine Institute

Campus mail 2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710

Phone (919) 681-8193

My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.

Education and Training

Ph.D., Duke University, 2010

Grants

Publications

Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.

PMID

34242577

Full Text

Fries, Chelsea N., Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, et al. “HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.” Scientific Reports 11, no. 1 (July 14, 2021): 14494. https://doi.org/10.1038/s41598-021-93702-x.

PMID

34262096

Full Text

Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “HIV mRNA Vaccines-Progress and Future Paths.” Vaccines (Basel) 9, no. 2 (February 7, 2021). https://doi.org/10.3390/vaccines9020134.

PMID

33562203

Full Text

Cain, Derek W., and John A. Cidlowski. “After 62 years of regulating immunity, dexamethasone meets COVID-19.” Nat Rev Immunol 20, no. 10 (October 2020): 587–88. https://doi.org/10.1038/s41577-020-00421-x.

PMID

32778829

Full Text

Cain, Derek W., Carl D. Bortner, David Diaz-Jimenez, Maria G. Petrillo, Amanda Gruver-Yates, and John A. Cidlowski. “Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.” J Immunol 205, no. 3 (August 1, 2020): 619–29. https://doi.org/10.4049/jimmunol.1901135.

PMID

32571841

Full Text

Tian, Ming, Kelly McGovern, Hwei-Ling Cheng, Peyton Waddicor, Lisa Rieble, Mai Dao, Yiwei Chen, et al. “Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.” Proc Natl Acad Sci U S A 117, no. 14 (April 7, 2020): 7929–40. https://doi.org/10.1073/pnas.1921996117.

PMID

32209668

Full Text

Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.

PMID

32075963

Full Text

Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.

PMID

31806786

Full Text

Nelson, Ashley N., Ria Goswami, Maria Dennis, Joshua Tu, Riley J. Mangan, Pooja T. Saha, Derek W. Cain, et al. “Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.” J Virol 93, no. 15 (August 1, 2019). https://doi.org/10.1128/JVI.00168-19.

PMID

31092583

Full Text

Pardi, Norbert, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert J. Parks, Hiromi Muramatsu, et al. “Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques.” Mol Ther Nucleic Acids 15 (April 15, 2019): 36–47. https://doi.org/10.1016/j.omtn.2019.03.003.

PMID

30974332

Full Text

Derek Wilson Cain, PhD

Education and Training

Grants

Publications

Pages