Donghai Wang, PhD

Assistant Professor in Medicine
Assistant Professor in Immunology
Member of the Duke Cancer Institute
Campus mail DUMC Box 3544, Durham, NC 27710
Phone (919) 684-5586
Email address donghai.wang@duke.edu

Inflammation underlies a variety of human diseases such as obesity, diabetes, cardiovascular diseases, neurodegenerative diseases, arthritis and cancer. Together, these diseases constitute a major challenge to the well being of modern human society. Understanding the fundamental mechanisms of inflammation may provide rationales for designing novel interventions to treat these maladies. Autoinflammatory diseases are an emerging family of illness, characterized by dysregulation of innate immune responses. Studies of these hereditary human disorders have provided invaluable insight into basic cellular and molecular mechanisms of the innate immune responses and have contributed significantly to the development of targeted therapies for common human inflammatory diseases such as arthritis. My long term goal is to understand the pathophysiological mechanisms of autoinflammatory diseases and to apply knowledge from such studies to develop novel treatment of inflammatory human diseases. Our recent studies of one of such diseases, namely mevalonate kinase deficiency, has allowed us to unravel the unexpected connection between the cholesterol-biosynthesis mevalonate pathway and toll like receptor (TLR)-mediated phosphatidyl inosital 3(PI3)-kinase signaling. These exciting new discoveries will greatly advance our knowledge of innate immune signaling and may provide clues for new interventions of a variety of human diseases.

Education and Training

  • Ph.D., Sun Yat Sen University (China), 2004

Publications

Yang, B, Suwanpradid, J, Sanchez-Lagunes, R, Choi, HW, Hoang, P, Wang, D, Abraham, SN, and MacLeod, AS. "IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense." May 2017.

PMID
28132857
Full Text

Ratner, D, Orning, MPA, Proulx, MK, Wang, D, Gavrilin, MA, Wewers, MD, Alnemri, ES, Johnson, PF, Lee, B, Mecsas, J, Kayagaki, N, Goguen, JD, and Lien, E. "The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation." Plos Pathogens 12, no. 12 (December 2, 2016): e1006035-null.

PMID
27911947
Full Text

Akula, MK, Shi, M, Jiang, Z, Foster, CE, Miao, D, Li, AS, Zhang, X, Gavin, RM, Forde, SD, Germain, G, Carpenter, S, Rosadini, CV, Gritsman, K, Chae, JJ, Hampton, R, Silverman, N, Gravallese, EM, Kagan, JC, Fitzgerald, KA, Kastner, DL, Golenbock, DT, Bergo, MO, and Wang, D. "Control of the innate immune response by the mevalonate pathway." Nature Immunology 17, no. 8 (August 2016): 922-929.

PMID
27270400
Full Text

Wang, D, Höing, S, Patterson, HC, Ahmad, UM, Rathinam, VAK, Rajewsky, K, Fitzgerald, KA, and Golenbock, DT. "Inflammation in Mice Ectopically Expressing Human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T Mutant Proteins." Journal of Biological Chemistry 288, no. 7 (February 15, 2013): 4594-4601.

Full Text

Hsu, Y-MS, Zhang, Y, You, Y, Wang, D, Li, H, Duramad, O, Qin, X-F, Dong, C, and Lin, X. "The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens." Nature Immunology 8, no. 2 (February 2007): 198-205.

Full Text

Wang, D. "A requirement for CARMA1 in TCR-induced NF-kappa B activation."

Scholars@Duke

Wang, D. "Cytoplasmic Igα Serine/Threonines Fine-Tune Igα Tyrosine Phosphorylation and Limit Bone Marrow Plasma Cell Formation."

Scholars@Duke

Wang, D. "Sox4 Is Required for the Survival of Pro-B Cells."

Scholars@Duke

Wang, D. "Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection."

Scholars@Duke

Wang, D. "CARMA3 deficiency abrogates G protein-coupled receptor-induced Nf-kB activation."

Scholars@Duke

Pages