Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Mentz, Robert J., Jonathan Buggey, Mona Fiuzat, Mads K. Ersbøll, Phillip J. Schulte, Adam D. DeVore, Eric L. Eisenstein, Kevin J. Anstrom, Christopher M. OʼConnor, and Eric J. Velazquez. “Torsemide versus furosemide in heart failure patients: insights from Duke University Hospital..” J Cardiovasc Pharmacol 65, no. 5 (May 2015): 438–43. https://doi.org/10.1097/FJC.0000000000000212.

PMID
25945862
Full Text

Buggey, Jonathan, Robert J. Mentz, Bertram Pitt, Eric L. Eisenstein, Kevin J. Anstrom, Eric J. Velazquez, and Christopher M. O’Connor. “A reappraisal of loop diuretic choice in heart failure patients..” Am Heart J 169, no. 3 (March 2015): 323–33. https://doi.org/10.1016/j.ahj.2014.12.009.

PMID
25728721
Full Text

Østbye, Truls, Marissa Stroo, Rebecca J. N. Brouwer, Bercedis L. Peterson, Eric L. Eisenstein, Bernard F. Fuemmeler, Julie Joyner, Libby Gulley, and John M. Dement. “Steps to Health employee weight management randomized control trial: short-term follow-up results..” J Occup Environ Med 57, no. 2 (February 2015): 188–95. https://doi.org/10.1097/JOM.0000000000000335.

PMID
25654520
Full Text

Povsic, Thomas J., Samuel Broderick, Kevin J. Anstrom, Linda K. Shaw, E Magnus Ohman, Eric L. Eisenstein, Peter K. Smith, and John H. Alexander. “Predictors of Long-term Clinical Endpoints in Patients With Refractory Angina.” Journal of the American Heart Association 4, no. 2 (February 2015). https://doi.org/10.1161/JAHA.114.001287.

Full Text

Povsic, Thomas J., Samuel Broderick, Kevin J. Anstrom, Linda K. Shaw, E Magnus Ohman, Eric L. Eisenstein, Peter K. Smith, and John H. Alexander. “Predictors of long-term clinical endpoints in patients with refractory angina..” J Am Heart Assoc 4, no. 2 (January 30, 2015). https://doi.org/10.1161/JAHA.114.001287.

PMID
25637344
Full Text

Eisenstein, Eric L., and Keith A. Butler. “Health informatics-enabled workflow redesign and evaluation..” Stud Health Technol Inform 208 (2015): 131–36.

PMID
25676961
Scholars@Duke

Anstrom, Kevin J., J Matthew Brennan, Eric L. Eisenstein, Jerome J. Federspiel, David Dai, Eric D. Peterson, and Pamela S. Douglas. “Examination of the treatment selection process in a multicenter observational study..” Circ Cardiovasc Qual Outcomes 7, no. 5 (September 2014): 764–69. https://doi.org/10.1161/CIRCOUTCOMES.113.000482.

PMID
25116898
Full Text

Wharton, Gerold T., M Dianne Murphy, Debbie Avant, John V. Goldsmith, Grace Chai, William J. Rodriguez, and Eric L. Eisenstein. “Impact of pediatric exclusivity on drug labeling and demonstrations of efficacy..” Pediatrics 134, no. 2 (August 2014): e512–18. https://doi.org/10.1542/peds.2013-2987.

PMID
25022732
Full Text

Mentz, Robert J., Jonathan Buggey, Phillip J. Schulte, Adam D. DeVore, Kevin J. Anstrom, Eric L. Eisenstein, Mona Fiuzat, Christopher M. O’Connor, and Eric J. Velazquez. “Torsemide vs. Furosemide in Heart Failure Patients: Insights from Duke University Hospital.” In Journal of Cardiac Failure, 20:S95–S95. Elsevier BV, 2014. https://doi.org/10.1016/j.cardfail.2014.06.267.

Full Text

Miller, Timothy E., Julie K. Thacker, William D. White, Christopher Mantyh, John Migaly, Juying Jin, Anthony M. Roche, et al. “Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol..” Anesth Analg 118, no. 5 (May 2014): 1052–61. https://doi.org/10.1213/ANE.0000000000000206.

PMID
24781574
Full Text

Pages