Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Community and Family Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Eisenstein, EL, Anstrom, KJ, Edwards, R, Willis, JM, Simo, J, and Lobach, DF. "Population-based clinical decision support: a clinical and economic evaluation." Studies in Health Technology and Informatics 180 (January 2012): 343-347.

PMID
22874209
Scholars@Duke

Eisenstein, EL, Diener, LW, Nahm, M, and Weinfurt, KP. "Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research study." J Med Syst 35, no. 6 (December 2011): 1521-1530.

PMID
20703765
Full Text

Tsai, TT, Messenger, JC, Brennan, JM, Patel, UD, Dai, D, Piana, RN, Anstrom, KJ, Eisenstein, EL, Dokholyan, RS, Peterson, ED, and Douglas, PS. "Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database." Journal of the American College of Cardiology 58, no. 18 (October 2011): 1859-1869.

PMID
22018296
Full Text

Anstrom, KJ, and Eisenstein, EL. "From batting average to wins above replacement to composite end points-refining clinical research using baseball statistical methods." Am Heart J 161, no. 5 (May 2011): 805-806.

PMID
21570507
Full Text

Hillegass, WB, Patel, MR, Anstrom, KJ, Dai, D, Klein, LW, Guram, HS, Eisenstein, EL, Peterson, ED, Messenger, JC, and Douglas, PS. "ACUTE AND LONG-TERM OUTCOMES IN OLDER DIABETIC PATIENTS RECEIVING A CORONARY STENT: CONTEMPORARY RESULTS IN 405,679 PATIENTS." April 2011.

Full Text

Eisenstein, EL, Kawamoto, K, Anstrom, KJ, Willis, JM, Silvey, GM, Johnson, FS, Edwards, R, Mise, J, Yaggy, SD, and Lobach, DF. "Clinical and economic results from a randomized trial of clinical decision support in a rural health network." Studies in Health Technology and Informatics 164 (January 2011): 77-81.

PMID
21335691
Scholars@Duke

Walden, A, Nahm, M, Barnett, ME, Conde, JG, Dent, A, Fadiel, A, Perry, T, Tolk, C, Tcheng, JE, and Eisenstein, EL. "Economic analysis of centralized vs. decentralized electronic data capture in multi-center clinical studies." Studies in Health Technology and Informatics 164 (January 2011): 82-88.

PMID
21335692
Scholars@Duke

Eisenstein, EL, Juzwishin, D, Kushniruk, AW, and Nahm, M. "Defining a framework for health information technology evaluation." Studies in Health Technology and Informatics 164 (January 2011): 94-99.

PMID
21335694
Scholars@Duke

Frendl, DM, Chang, JT, Wagner, GS, and Eisenstein, EL. "Wireless Transmission of a Prehospital Electrocardiogram Can be Cost Effective for Patients with ST-Elevation Myocardial Infarction." CIRCULATION 122, no. 21 (November 23, 2010).

Scholars@Duke

Tsai, TT, Messenger, JC, Brennan, JM, Patel, UD, Dai, D, Piana, R, Anstrom, KJ, Eisenstein, EL, Dokholyan, RS, Peterson, ED, and Douglas, PS. "Contemporary Risk of Follow-up Adverse Events in Older Patients with Chronic Kidney Disease and Dialysis Undergoing Percutaneous Coronary Interventions: A Report from the Merged NCDR CMS Registry." Circulation 122, no. 21 (November 23, 2010).

Scholars@Duke

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