Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Eisenstein, Eric L., Kevin J. Anstrom, Rex Edwards, Janese M. Willis, Jessica Simo, and David F. Lobach. “Population-based clinical decision support: a clinical and economic evaluation..” Stud Health Technol Inform 180 (2012): 343–47.

PMID
22874209
Scholars@Duke

Eisenstein, Eric L., Lawrence W. Diener, Meredith Nahm, and Kevin P. Weinfurt. “Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research study..” J Med Syst 35, no. 6 (December 2011): 1521–30. https://doi.org/10.1007/s10916-010-9429-8.

PMID
20703765
Full Text

Tsai, Thomas T., John C. Messenger, J Matthew Brennan, Uptal D. Patel, David Dai, Robert N. Piana, Kevin J. Anstrom, et al. “Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database..” J Am Coll Cardiol 58, no. 18 (October 25, 2011): 1859–69. https://doi.org/10.1016/j.jacc.2011.06.056.

PMID
22018296
Full Text

Anstrom, Kevin J., and Eric L. Eisenstein. “From batting average to wins above replacement to composite end points-refining clinical research using baseball statistical methods..” Am Heart J 161, no. 5 (May 2011): 805–6. https://doi.org/10.1016/j.ahj.2011.01.023.

PMID
21570507
Full Text

Hillegass, William B., Manesh R. Patel, Kevin J. Anstrom, David Dai, Lloyd W. Klein, Hitinder S. Guram, Eric L. Eisenstein, Eric D. Peterson, John C. Messenger, and Pamela S. Douglas. “ACUTE AND LONG-TERM OUTCOMES IN OLDER DIABETIC PATIENTS RECEIVING A CORONARY STENT: CONTEMPORARY RESULTS IN 405,679 PATIENTS.” In Journal of the American College of Cardiology, 57:E1695–E1695. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)61695-1.

Full Text

Eisenstein, Eric L., Kensaku Kawamoto, Kevin J. Anstrom, Janese M. Willis, Garry M. Silvey, Fred S. Johnson, Rex Edwards, Jean Mise, Susan D. Yaggy, and David F. Lobach. “Clinical and economic results from a randomized trial of clinical decision support in a rural health network..” Stud Health Technol Inform 164 (2011): 77–81.

PMID
21335691
Scholars@Duke

Walden, Anita, Meredith Nahm, M Edwina Barnett, Jose G. Conde, Andrew Dent, Ahmed Fadiel, Theresa Perry, Chris Tolk, James E. Tcheng, and Eric L. Eisenstein. “Economic analysis of centralized vs. decentralized electronic data capture in multi-center clinical studies..” Stud Health Technol Inform 164 (2011): 82–88.

PMID
21335692
Scholars@Duke

Eisenstein, Eric L., Don Juzwishin, Andre W. Kushniruk, and Meredith Nahm. “Defining a framework for health information technology evaluation..” Stud Health Technol Inform 164 (2011): 94–99.

PMID
21335694
Scholars@Duke

Tsai, Thomas T., John C. Messenger, J Matthew Brennan, Uptal D. Patel, David Dai, Robert Piana, Kevin J. Anstrom, et al. “Contemporary Risk of Follow-up Adverse Events in Older Patients with Chronic Kidney Disease and Dialysis Undergoing Percutaneous Coronary Interventions: A Report from the Merged NCDR CMS Registry.” Circulation 122, no. 21 (November 23, 2010).

Scholars@Duke

Frendl, Daniel M., Joshua T. Chang, Galen S. Wagner, and Eric L. Eisenstein. “Wireless Transmission of a Prehospital Electrocardiogram Can be Cost Effective for Patients with ST-Elevation Myocardial Infarction.” Circulation 122, no. 21 (November 23, 2010).

Scholars@Duke

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