Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 Msrb1, Durham, NC 27705
Phone (919) 668-2688

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Udofot, Ofonime, Li-Hsien Lin, William H. Thiel, Megan Erwin, Emily Turner, Francis J. Miller, Paloma H. Giangrande, and Saami K. Yazdani. “Delivery of Cell-Specific Aptamers to the Arterial Wall with an Occlusion Perfusion Catheter..” Mol Ther Nucleic Acids 16 (June 7, 2019): 360–66. https://doi.org/10.1016/j.omtn.2019.03.005.

PMID
30986697
Full Text

Sonkar, Vijay K., Rahul Kumar, Melissa Jensen, Brett A. Wagner, Anjali A. Sharathkumar, Francis J. Miller, MaryBeth Fasano, Steven R. Lentz, Garry R. Buettner, and Sanjana Dayal. “Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice..” Blood Adv 3, no. 8 (April 23, 2019): 1272–84. https://doi.org/10.1182/bloodadvances.2018025569.

PMID
30995985
Full Text

Lei, Beilei, Kamie Snow, Jacob Fang, Robert M. Tighe, Paloma H. Giangrande, and Francis J. Miller. “Inhalation of an RNA Aptamer Targeting Extracellular Histones Protects from Acute Lung Injury.” In Molecular Therapy, 27:334–334. CELL PRESS, 2019.

Scholars@Duke

Gimenez, Marcela, Sidney Veríssimo-Filho, Ilka Wittig, Brandon M. Schickling, Fabian Hahner, Christoph Schürmann, Luis E. S. Netto, et al. “Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells..” Arterioscler Thromb Vasc Biol 39, no. 2 (February 2019): 224–36. https://doi.org/10.1161/ATVBAHA.118.311038.

PMID
30580571
Full Text

Urak, Kevin T., Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, et al. “RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome..” Nat Commun 10, no. 1 (January 10, 2019). https://doi.org/10.1038/s41467-018-08030-y.

PMID
30631065
Full Text

Zhang, Lisheng, Jiao-Hui Wu, Tai-Qin Huang, Igor Nepliouev, Leigh Brian, Zhushan Zhang, Virginia Wertman, et al. “Drebrin regulates angiotensin II-induced aortic remodelling..” Cardiovasc Res 114, no. 13 (November 1, 2018): 1806–15. https://doi.org/10.1093/cvr/cvy151.

PMID
29931051
Full Text

Giangrande, Paloma H., Francis J. Miller, and William H. Thiel. “VSMC Specific Aptamer Ligands for the Next Generation of DES to Prevent Neointimal Formation.” In Molecular Therapy, 26:146–146. CELL PRESS, 2018.

Scholars@Duke

Leisegang, Matthias S., Christian Fork, Ivana Josipovic, Florian Martin Richter, Jens Preussner, Jiong Hu, Matthew J. Miller, et al. “Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function..” Circulation 136, no. 1 (July 4, 2017): 65–79. https://doi.org/10.1161/CIRCULATIONAHA.116.026991.

PMID
28351900
Full Text

Urak, Kevin T., Francis J. Miller, and Paloma Giangrande. “Treatment of Sepsis by Neutralization of Extracellular Histones with Nucleic Acid Aptamers.” In Molecular Therapy, 25:35–35. CELL PRESS, 2017.

Scholars@Duke

Leisegang, M. S., C. Fork, I. Josipovic, F. Richler, J. Preussner, M. J. Millers, J. Epah, et al. “LncRNA MANTIS facilitates endothelial angiogenic function.” In Acta Physiologica, 219:58–58. WILEY, 2017.

Scholars@Duke

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