Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Onwuemene, OA, Grambow, SC, Patel, CB, Mentz, RJ, Milano, CA, Rogers, JG, Metjian, AD, Arepally, GM, and Ortel, TL. "Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study." Journal of clinical apheresis (March 10, 2018).

PMID
29524240
Full Text

Haile, LA, Rao, R, Polumuri, SK, Arepally, GM, Keire, DA, Verthelyi, D, and Sommers, CD. "PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses." Thrombosis research 159 (November 2017): 39-47.

PMID
28968537
Full Text

Tanhehco, YC, Arepally, G, and Metjian, A. "Novel therapeutic approaches for thrombotic thrombocytopenic purpura." Current opinion in hematology 24, no. 6 (November 2017): 521-528.

PMID
28759473
Full Text

Abbes, S, Metjian, A, Gray, A, Martinu, T, Snyder, L, Chen, D-F, Ellis, M, Arepally, GM, and Onwuemene, O. "Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner." Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 21, no. 5 (October 2017): 441-450. (Review)

PMID
28880430
Full Text

Fountain, EM, and Arepally, GM. "Etiology and complications of thrombocytopenia in hospitalized medical patients." Journal of thrombosis and thrombolysis 43, no. 4 (May 2017): 429-436.

PMID
28054307
Full Text

Arepally, GM. "Heparin-induced thrombocytopenia." Blood 129, no. 21 (May 2017): 2864-2872. (Review)

PMID
28416511
Full Text

Hayes, V, Johnston, I, Arepally, GM, McKenzie, SE, Cines, DB, Rauova, L, and Poncz, M. "Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia." The Journal of clinical investigation 127, no. 3 (March 2017): 1090-1098.

PMID
28218620
Full Text

Welsby, IJ, Krakow, EF, Heit, JA, Williams, EC, Arepally, GM, Bar-Yosef, S, Kong, DF, Martinelli, S, Dhakal, I, Liu, WW, Krischer, J, and Ortel, TL. "The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery." Journal of thrombosis and haemostasis : JTH 15, no. 1 (January 2017): 57-65.

PMID
27714919
Full Text

Fountain, EM, Moses, MC, Park, LP, Woods, CW, and Arepally, GM. "Thrombocytopenia in hospitalized patients with severe clostridium difficile infection." Journal of thrombosis and thrombolysis 43, no. 1 (January 2017): 38-42.

PMID
27614757
Full Text

Onwuemene, O, and Arepally, GM. "Heparin-induced thrombocytopenia: research and clinical updates." Hematology. American Society of Hematology. Education Program 2016, no. 1 (December 2016): 262-268. (Review)

PMID
27913490
Full Text

Pages