Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Barbour, T., M. Scully, G. Ariceta, S. Cataland, K. Garlo, N. Heyne, Y. Luque, et al. “Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults.” Kidney International Reports 6, no. 6 (June 1, 2021): 1603–13. https://doi.org/10.1016/j.ekir.2021.03.884.

Full Text

Dhoot, Roshni, Aman Kansal, Chauncy Handran, Tarek Haykal, James Ronald, Matthew Kappus, Gowthami M. Arepally, Mark Graham, and John J. Strouse. “Thrombocytopenia and splanchnic thrombosis after Ad26.COV2.S vaccination successfully treated with transjugular intrahepatic portosystemic shunting and thrombectomy.” Am J Hematol, May 31, 2021. https://doi.org/10.1002/ajh.26258.

PMID
34057234
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Rondeau, Eric, Marie Scully, Gema Ariceta, Tom Barbour, Spero Cataland, Nils Heyne, Yoshitaka Miyakawa, et al. “Corrigendum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D and Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment." Kidney Int. 2020;97:1287-1296.” Kidney Int 99, no. 5 (May 2021): 1244. https://doi.org/10.1016/j.kint.2021.03.008.

PMID
33892867
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Rondeau, Eric, Marie Scully, Gema Ariceta, Tom Barbour, Spero Cataland, Nils Heyne, Yoshitaka Miyakawa, et al. “Erratum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D, Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" Kidney Int. 2020;97:1287-1296.” Kidney Int 98, no. 6 (December 2020): 1621. https://doi.org/10.1016/j.kint.2020.11.001.

PMID
33276869
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Johnston, Ian, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, et al. “Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.” Blood 135, no. 15 (April 9, 2020): 1270–80. https://doi.org/10.1182/blood.2018881607.

PMID
32077913
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Gollomp, Kandace, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin Hudock, Lubica Rauova, M Anna Kowalska, and Mortimer Poncz. “Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.” Blood 135, no. 10 (March 5, 2020): 743–54. https://doi.org/10.1182/blood.2019002329.

PMID
31722003
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Achey, Meredith A., Uttara P. Nag, Victoria L. Robinson, Christopher R. Reed, Gowthami M. Arepally, Jerrold H. Levy, and Elisabeth T. Tracy. “The Developing Balance of Thrombosis and Hemorrhage in Pediatric Surgery: Clinical Implications of Age-Related Changes in Hemostasis.” Clin Appl Thromb Hemost 26 (January 2020): 1076029620929092. https://doi.org/10.1177/1076029620929092.

PMID
32584601
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Gollomp, Kandace, Amrita Sarkar, Gowthami Arepally, Douglas B. Cines, M Anna Kowalska, Lubica Rauova, and Mortimer Poncz. “Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis.” Blood 134, no. Supplement_1 (November 13, 2019): 10. https://doi.org/10.1182/blood-2019-123132.

PMID
31723995
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Pages