Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Homi, HM, Sheng, H, Arepally, GM, Mackensen, GB, and Grocott, HP. "Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass." Anesth Analg 111, no. 1 (July 2010): 38-45.

PMID
20519424
Full Text

Arepally, G, Bauer, KA, Bhatt, DL, Merli, GJ, Naccarelli, GV, Carter, RD, Karcher, RB, Berry, CA, Keaton, KL, and Stowell, SA. "The use of antithrombotic therapies in the prevention and treatment of arterial and venous thrombosis: a survey of current knowledge and practice supporting the need for clinical education." Crit Pathw Cardiol 9, no. 1 (March 2010): 41-48.

PMID
20215910
Full Text

Welsby, IJ, Um, J, Milano, CA, Ortel, TL, and Arepally, G. "Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia." Anesthesia and Analgesia 110, no. 1 (January 2010): 30-35.

PMID
19933539
Full Text

Arepally, GM, and Ortel, TL. "Heparin-induced thrombocytopenia." Annu Rev Med 61 (2010): 77-90. (Review)

PMID
20059332
Full Text

Glover, S, Key, NS, Arepally, GM, Mackman, N, and Kasthuri, RS. "Characterization of Receptors Involved in Heparin Antibody Complex Mediated Induction of Tissue Factor Expression in Monocytes." November 20, 2009.

Scholars@Duke

Chudasama, S, Espinasse, B, Wiesner, MR, and Arepally, GM. "Heparin Forms Macromolecular Complexes with Protamine and Lysozyme." November 20, 2009.

Scholars@Duke

Smyth, SS, McEver, RP, Weyrich, AS, Morrell, CN, Hoffman, MR, Arepally, GM, French, PA, Dauerman, HL, Becker, RC, and 2009 Platelet Colloquium Participants, . "Platelet functions beyond hemostasis." Journal of Thrombosis and Haemostasis : Jth 7, no. 11 (November 2009): 1759-1766. (Review)

PMID
19691483
Full Text

Pai, PJ, McCracken, JE, and Arepally, GM. "SEROPREVALENCE OF PF4/HEPARIN ANTIBODIES AMONG BLOOD BANK DONORS." PEDIATRIC BLOOD & CANCER 52, no. 6 (June 2009): 710-711.

Scholars@Duke

Arepally, GM. "Nothing typical about HIT." Blood 113, no. 20 (May 14, 2009): 4825-4826.

PMID
19443669
Full Text

Suvarna, S, Qi, R, and Arepally, GM. "Optimization of a murine immunization model for study of PF4/heparin antibodies." J Thromb Haemost 7, no. 5 (May 2009): 857-864.

PMID
19245419
Full Text

Pages