Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Arepally, GM, and Ortel, TL. "Heparin-induced thrombocytopenia." Annu Rev Med 61 (2010): 77-90. (Review)

PMID
20059332
Full Text

Glover, S, Key, NS, Arepally, GM, Mackman, N, and Kasthuri, RS. "Characterization of Receptors Involved in Heparin Antibody Complex Mediated Induction of Tissue Factor Expression in Monocytes." November 20, 2009.

Scholars@Duke

Chudasama, S, Espinasse, B, Wiesner, MR, and Arepally, GM. "Heparin Forms Macromolecular Complexes with Protamine and Lysozyme." November 20, 2009.

Scholars@Duke

Smyth, SS, McEver, RP, Weyrich, AS, Morrell, CN, Hoffman, MR, Arepally, GM, French, PA, Dauerman, HL, Becker, RC, and 2009 Platelet Colloquium Participants, . "Platelet functions beyond hemostasis." J Thromb Haemost 7, no. 11 (November 2009): 1759-1766. (Review)

PMID
19691483
Full Text

Pai, PJ, McCracken, JE, and Arepally, GM. "SEROPREVALENCE OF PF4/HEPARIN ANTIBODIES AMONG BLOOD BANK DONORS." PEDIATRIC BLOOD & CANCER 52, no. 6 (June 2009): 710-711.

Scholars@Duke

Arepally, GM. "Nothing typical about HIT." Blood 113, no. 20 (May 14, 2009): 4825-4826.

PMID
19443669
Full Text

Suvarna, S, Qi, R, and Arepally, GM. "Optimization of a murine immunization model for study of PF4/heparin antibodies." J Thromb Haemost 7, no. 5 (May 2009): 857-864.

PMID
19245419
Full Text

Rauova, L, Arepally, G, Kenzie, SEM, Konkle, BA, Cines, DB, and Poncz, M. "Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT)." Journal of Thrombosis and Haemostasis 7, no. SUPPL. 1 (2009): 249-252.

PMID
19630810
Full Text

Ragni, MV, Ojeifo, O, Feng, J, Yan, J, Hill, KA, Sommer, SS, Trucco, MN, Brambilla, DJ, Brettler, D, Forand, P, Geary, P, Ewenstein, B, Sweeney, C, Aledort, L, Seremetis, S, McCarthy, J, DiMichelel, D, Goldberg, I, Barron, L, Hams, A, White, G, Nielsen, B, Grimsley, A, Cox-Gill, J, Boyd, A, Green, D, Boggio, L, Harris, S, Hoots, K, Cantini, M, Buchanan, G, Rutherford, C, Dunnagan, P, Haire, W, Hanlon, E, Kisler, T, Sally, S, Giambartolomei, S, Arepally, G, Shhwartz, M, Addiego, J, and Matsunaga, A et al. "Risk factors for inhibitor formation in haemophilia: A prevalent case-control study." Haemophilia 15, no. 5 (2009): 1074-1082.

PMID
19563499
Full Text

Diaz, GC, Prowda, J, Lo, IJ, Arepally, GM, Evans, N, Wheeless, Y, Samstein, B, Guarrera, JV, and Renz, JF. "Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors." Liver Transpl 14, no. 12 (December 2008): 1803-1809. (Review)

PMID
19025920
Full Text

Pages