Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Zheng, Yongwei, Mei Yu, Andrew Podd, Liudi Yuan, Debra K. Newman, Renren Wen, Gowthami Arepally, and Demin Wang. “Critical role for mouse marginal zone B cells in PF4/heparin antibody production.” Blood 121, no. 17 (April 25, 2013): 3484–92. https://doi.org/10.1182/blood-2013-01-477091.

PMID
23460609
Full Text

Lee, Grace M., Ian J. Welsby, Barbara Phillips-Bute, Thomas L. Ortel, and Gowthami M. Arepally. “High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass.” Blood 121, no. 15 (April 11, 2013): 2828–35. https://doi.org/10.1182/blood-2012-11-469130.

PMID
23422751
Full Text

Lee, Grace M., Ian Welsby, Barbara Phillips Bute, Thomas L. Ortel, and Gowthami M. Arepally. “High Incidence of Antibodies to Protamine and Protamine/Heparin Complexes in Patients Undergoing Cardiopulmonary Bypass.” In Blood, 120:3344–3344. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.3344.3344.

Full Text

Lee, Grace M., Ian Welsby, Barbara Phillips Bute, Thomas L. Ortel, and Gowthami M. Arepally. “High Incidence of Antibodies to Protamine and Protamine/Heparin Complexes in Patients Undergoing Cardiopulmonary Bypass.” In Blood, Vol. 120, 2012.

Scholars@Duke

Espinasse, Benjamin, Manali Joglekar, Giancarlo Valiente, and Gowthami M. Arepally. “Novel Techniques for Measurement of Variable Sized PF4/H Complexes.” In Blood, 120:2204–2204. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.2204.2204.

Full Text

Sachais, Bruce S., Rustem I. Litvinov, Serge V. Yarovoi, Lubica Rauova, Jillian L. Hinds, Ann H. Rux, Gowthami M. Arepally, et al. “Dynamic antibody-binding properties in the pathogenesis of HIT.” Blood 120, no. 5 (August 2, 2012): 1137–42. https://doi.org/10.1182/blood-2012-01-407262.

PMID
22577175
Full Text

Pages