Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Edwards, Robert J., Katayoun Mansouri, Victoria Stalls, Kartik Manne, Brian Watts, Rob Parks, Sophie M. C. Gobeil, et al. “Cold sensitivity of the SARS-CoV-2 spike ectodomain.” Biorxiv, July 13, 2020. https://doi.org/10.1101/2020.07.12.199588.

PMID
32699852
Full Text

Sempowski, Gregory D., Kevin O. Saunders, Priyamvada Acharya, Kevin J. Wiehe, and Barton F. Haynes. “Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.” Cell 181, no. 7 (June 25, 2020): 1458–63. https://doi.org/10.1016/j.cell.2020.05.041.

PMID
32492407
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Schwartz, A., M. Stiegel, N. Greeson, A. Vogel, W. Thomann, M. Brown, G. D. Sempowski, et al. “Decontamination and Reuse of N95 Respirators with Hydrogen Peroxide Vapor to Address Worldwide Personal Protective Equipment Shortages During the SARS-CoV-2 (COVID-19) Pandemic.” Applied Biosafety 25, no. 2 (June 1, 2020): 67–70. https://doi.org/10.1177/1535676020919932.

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Kwock, Jeffery T., Chelsea Handfield, Jutamas Suwanpradid, Peter Hoang, Michael J. McFadden, Kevin F. Labagnara, Lauren Floyd, et al. “IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.” Sci Adv 6, no. 14 (April 2020): eaay3245. https://doi.org/10.1126/sciadv.aay3245.

PMID
32270034
Full Text

Thanh, Lam Tuan, Dena L. Toffaletti, Jennifer L. Tenor, Charles Giamberardino, Gregory D. Sempowski, Yohannes Asfaw, Hai Trieu Phan, et al. “Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam.” Med Mycol, March 20, 2020. https://doi.org/10.1093/mmy/myaa013.

PMID
32196550
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Johnson-Weaver, Brandi T., Gregory D. Sempowski, and Herman F. Staats. “Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice.” Allergy 74, no. 11 (November 2019): 2220–23. https://doi.org/10.1111/all.13738.

PMID
30746720
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Michalson, Kristofer T., Andrew N. Macintyre, Gregory D. Sempowski, J Daniel Bourland, Timothy D. Howard, Gregory A. Hawkins, Gregory O. Dugan, J Mark Cline, and Thomas C. Register. “Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.” Radiat Res 192, no. 2 (August 2019): 121–34. https://doi.org/10.1667/RR15310.1.

PMID
31161966
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Choi, Hae Woong, Cliburn Chan, Ivo D. Shterev, Heather E. Lynch, Taylor J. Robinette, Brandi T. Johnson-Weaver, Jianling Shi, et al. “Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.” Slas Discov 24, no. 6 (July 2019): 628–40. https://doi.org/10.1177/2472555219834699.

PMID
30917061
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Caudell, David L., Kristofer T. Michalson, Rachel N. Andrews, William W. Snow, J Daniel Bourland, Ryne J. DeBo, J Mark Cline, Gregory D. Sempowski, and Thomas C. Register. “Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation.” Radiat Res 192, no. 1 (July 2019): 40–52. https://doi.org/10.1667/RR15100.1.

PMID
31059377
Full Text

Poston, Taylor B., De’Ashia E. Lee, Toni Darville, Wujuan Zhong, Li Dong, Catherine M. O’Connell, Harold C. Wiesenfeld, Sharon L. Hillier, Gregory D. Sempowski, and Xiaojing Zheng. “Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.” J Infect Dis 220, no. 2 (June 19, 2019): 330–39. https://doi.org/10.1093/infdis/jiz087.

PMID
30820577
Full Text

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