Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Collier, MA, Junkins, RD, Gallovic, MD, Johnson, BM, Johnson, MM, Macintyre, AN, Sempowski, GD, Bachelder, EM, Ting, JP-Y, and Ainslie, KM. "Acetalated Dextran microparticles for co-delivery of STING and TLR7/8 agonists." Molecular Pharmaceutics (October 3, 2018).

PMID
30281314
Full Text

Jin, C, Shelburne, CP, Li, G, Potts, EN, Riebe, KJ, Sempowski, GD, Foster, WM, and Abraham, SN. "Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation." The Journal of Clinical Investigation 128, no. 10 (October 2018): 4742-4743.

PMID
30272582
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Hayashi, T, Lynch, HE, Geyer, S, Yoshida, K, Furudoi, K, Sasaki, K, Morishita, Y, Nagamura, H, Maki, M, Hu, Y, Hayashi, I, Kyoizumi, S, Kusunoki, Y, Ohishi, W, Fujiwara, S, Misumi, M, Shterev, I, Nikolich-Žugich, J, Murasko, D, Hale, LP, Sempowski, GD, and Nakachi, K. "Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort." September 28, 2018.

PMID
30274868
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Zhu, W, Tomberg, J, Knilans, KJ, Anderson, JE, McKinnon, KP, Sempowski, GD, Nicholas, RA, and Duncan, JA. "Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation." The Journal of Biological Chemistry 293, no. 28 (July 2018): 11218-11229.

PMID
29752412
Full Text

Shterev, ID, Dunson, DB, Chan, C, and Sempowski, GD. "Bayesian Multi-Plate High-Throughput Screening of Compounds." Scientific Reports 8, no. 1 (June 22, 2018): 9551-null.

PMID
29934615
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Junkins, RD, Gallovic, MD, Johnson, BM, Collier, MA, Watkins-Schulz, R, Cheng, N, David, CN, McGee, CE, Sempowski, GD, Shterev, I, McKinnon, K, Bachelder, EM, Ainslie, KM, and Ting, JP-Y. "A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination." January 2018.

PMID
29170142
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McCarthy, KR, Watanabe, A, Kuraoka, M, Do, KT, McGee, CE, Sempowski, GD, Kepler, TB, Schmidt, AG, Kelsoe, G, and Harrison, SC. "Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires." Immunity 48, no. 1 (January 2018): 174-184.e9.

PMID
29343437
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Kajimura, J, Lynch, HE, Geyer, S, French, B, Yamaoka, M, Shterev, ID, Sempowski, GD, Kyoizumi, S, Yoshida, K, Misumi, M, Ohishi, W, Hayashi, T, Nakachi, K, and Kusunoki, Y. "Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan." Radiation research 189, no. 1 (January 2018): 84-94.

PMID
29324175
Full Text

Kurkjian, CJ, Guo, H, Montgomery, ND, Cheng, N, Yuan, H, Merrill, JR, Sempowski, GD, Brickey, WJ, and Ting, JP-Y. "The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome." Scientific Reports 7, no. 1 (December 11, 2017): 17355-null.

PMID
29230065
Full Text

Kajimura, J, Lynch, HE, Geyer, S, French, B, Yamaoka, M, Shterev, ID, Sempowski, GD, Kyoizumi, S, Yoshida, K, Misumi, M, Ohishi, W, Hayashi, T, Nakachi, K, and Kusunoki, Y. "Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan." Radiation research (November 30, 2017).

PMID
29189104
Full Text

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