Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Choi, HW, Chan, C, Shterev, ID, Lynch, HE, Robinette, TJ, Johnson-Weaver, BT, Shi, J, Sempowski, GD, Kim, SY, Dickson, JK, Gooden, DM, Abraham, SN, and Staats, HF. "Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening." Slas Discovery : Advancing Life Sciences R & D (March 27, 2019): 2472555219834699-null.

PMID
30917061
Full Text

Poston, TB, Lee, DE, Darville, T, Zhong, W, Dong, L, O'Connell, CM, Wiesenfeld, HC, Hillier, SL, Sempowski, GD, and Zheng, X. "Cervical cytokines associated with Chlamydia trachomatis susceptibility and protection." The Journal of Infectious Diseases (March 2019).

PMID
30820577
Full Text

Johnson-Weaver, BT, Sempowski, GD, and Staats, HF. "Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice." Allergy (February 12, 2019). (Letter)

PMID
30746720
Full Text

Hale, LP, Rajam, G, Carlone, GM, Jiang, C, Owzar, K, Dugan, G, Caudell, D, Chao, N, Cline, JM, Register, TC, and Sempowski, GD. "Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques." Plos One 14, no. 2 (January 2019): e0210663-null.

PMID
30759098
Full Text

Collier, MA, Junkins, RD, Gallovic, MD, Johnson, BM, Johnson, MM, Macintyre, AN, Sempowski, GD, Bachelder, EM, Ting, JP-Y, and Ainslie, KM. "Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists." Molecular Pharmaceutics 15, no. 11 (November 2018): 4933-4946.

PMID
30281314
Full Text

Hayashi, T, Lynch, HE, Geyer, S, Yoshida, K, Furudoi, K, Sasaki, K, Morishita, Y, Nagamura, H, Maki, M, Hu, Y, Hayashi, I, Kyoizumi, S, Kusunoki, Y, Ohishi, W, Fujiwara, S, Misumi, M, Shterev, I, Nikolich-Žugich, J, Murasko, D, Hale, LP, Sempowski, GD, and Nakachi, K. "Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort." October 2018.

PMID
30274868
Full Text

Zhu, W, Tomberg, J, Knilans, KJ, Anderson, JE, McKinnon, KP, Sempowski, GD, Nicholas, RA, and Duncan, JA. "Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation." The Journal of Biological Chemistry 293, no. 28 (July 2018): 11218-11229.

PMID
29752412
Full Text

Shterev, ID, Dunson, DB, Chan, C, and Sempowski, GD. "Bayesian Multi-Plate High-Throughput Screening of Compounds." Scientific Reports 8, no. 1 (June 22, 2018): 9551-null.

PMID
29934615
Full Text

Lee, DE, Zhong, W, Dong, L, Russell, AR, O'Connell, C, Wiesenfeld, H, Hillier, S, Sempowski, GD, Zheng, X, and Darville, T. "Increased levels of Th1-inducing cytokines are detected in cervical secretions of women with Chlamydia trachomatis infection limited to their cervix." Annual Meeting of the American-Association-of-Immunologists (AAI). Austin, TX. May 4, 2018 - May 8, 2018.: AMER ASSOC IMMUNOLOGISTS, May 1, 2018.

Scholars@Duke

Junkins, RD, Gallovic, MD, Johnson, BM, Collier, MA, Watkins-Schulz, R, Cheng, N, David, CN, McGee, CE, Sempowski, GD, Shterev, I, McKinnon, K, Bachelder, EM, Ainslie, KM, and Ting, JP-Y. "A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination." January 2018.

PMID
29170142
Full Text

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