Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Matthias, Kathryn A., Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, and Margaret C. Bash. “Meningococcal Detoxified Outer Membrane Vesicle Vaccines Enhance Gonococcal Clearance in a Murine Infection Model.” J Infect Dis, September 8, 2021. https://doi.org/10.1093/infdis/jiab450.

PMID
34498079
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Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.

PMID
34242577
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Connolly, Kristie L., Michelle Pilligua-Lucas, Carolina Gomez, Allison C. Costenoble-Caherty, Anthony Soc, Knashka Underwood, Andrew N. Macintyre, Gregory D. Sempowski, and Ann E. Jerse. “Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection.” The Journal of Infectious Diseases 224, no. Supplement_2 (August 2021): S152–60. https://doi.org/10.1093/infdis/jiab211.

PMID
34396408
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Yu, Chen, Sejiro Littleton, Nicholas S. Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Yuchen Yang, et al. “Mucosal-associated invariant T cell responses differ by sex in COVID-19.” Med (N Y) 2, no. 6 (June 11, 2021): 755-772.e5. https://doi.org/10.1016/j.medj.2021.04.008.

PMID
33870241
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McCarthy, Kevin R., Tarra A. Von Holle, Laura L. Sutherland, Thomas H. Oguin, Gregory D. Sempowski, Stephen C. Harrison, and M Anthony Moody. “Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates.” Proc Natl Acad Sci U S A 118, no. 23 (June 8, 2021). https://doi.org/10.1073/pnas.2026752118.

PMID
34074774
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Hale, Laura P., Lynn Cheatham, Andrew N. Macintyre, Bonnie LaFleur, Brittany Sanders, Jesse Troy, Joanne Kurtzberg, and Gregory D. Sempowski. “T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.” Geroscience 43, no. 3 (June 2021): 1369–82. https://doi.org/10.1007/s11357-020-00301-1.

PMID
33420705
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Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.” Nature 594, no. 7864 (June 2021): 553–59. https://doi.org/10.1038/s41586-021-03594-0.

PMID
33971664
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Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, et al. “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.” Sci Adv 7, no. 26 (June 2021). https://doi.org/10.1126/sciadv.abg4901.

PMID
34172447
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Williams, Wilton B., R Ryan Meyerhoff, R. J. Edwards, Hui Li, Kartik Manne, Nathan I. Nicely, Rory Henderson, et al. “Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.” Cell 184, no. 11 (May 27, 2021): 2955-2972.e25. https://doi.org/10.1016/j.cell.2021.04.042.

PMID
34019795
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