Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Bowles, R. D., I. O. Karikari, D. N. VanDerwerken, M. S. Sinclair, R. D. Bell, K. J. Riebe, J. L. Huebner, V. B. Kraus, G. D. Sempowski, and L. A. Setton. “In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.” Eur J Pain 20, no. 3 (March 2016): 365–76. https://doi.org/10.1002/ejp.732.

PMID
26032161
Full Text

Samo, Melissa, Neelima R. Choudhary, Kristina J. Riebe, Ivo Shterev, Herman F. Staats, Gregory D. Sempowski, and Isabelle Leduc. “Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface.” Vaccine 34, no. 9 (February 2016): 1193–1200. https://doi.org/10.1016/j.vaccine.2016.01.024.

PMID
26812077
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Powell, Daniel A., Lydia M. Roberts, Hannah E. Ledvina, Gregory D. Sempowski, Roy Curtiss, and Jeffrey A. Frelinger. “Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.” Cell Immunol 299 (January 2016): 42–49. https://doi.org/10.1016/j.cellimm.2015.10.002.

PMID
26546408
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Feinstein, Lydia, Sara Ferrando-Martínez, Manuel Leal, Xuan Zhou, Gregory D. Sempowski, Derek E. Wildman, Monica Uddin, and Allison E. Aiello. “Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.” Biodemography Soc Biol 62, no. 2 (2016): 208–21. https://doi.org/10.1080/19485565.2016.1172199.

PMID
27337555
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Seed, Thomas M., Shiyun Xiao, Nancy Manley, Janko Nikolich-Zugich, Jason Pugh, Marcel Van den Brink, Yoko Hirabayashi, et al. “An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.” Int J Radiat Biol 92, no. 2 (2016): 59–70. https://doi.org/10.3109/09553002.2015.1106024.

PMID
26857121
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Wang, Yu, Zheng Zhang, Dong Ji, Guo-Feng Chen, Xia Feng, Lu-Lu Gong, Jian Guo, et al. “Regulation of T cell function by microRNA-720.” Sci Rep 5 (July 22, 2015): 12159. https://doi.org/10.1038/srep12159.

PMID
26199080
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DeBo, Ryne J., Thomas C. Register, David L. Caudell, Gregory D. Sempowski, Gregory Dugan, Shauna Gray, Kouros Owzar, et al. “Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.” Int J Radiat Biol 91, no. 6 (June 2015): 510–18. https://doi.org/10.3109/09553002.2015.1028597.

PMID
25786585
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Roberts, Lydia M., Hannah E. Ledvina, Shraddha Tuladhar, Deepa Rana, Shaun P. Steele, Gregory D. Sempowski, and Jeffrey A. Frelinger. “Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.” Immun Inflamm Dis 3, no. 2 (June 2015): 71–81. https://doi.org/10.1002/iid3.51.

PMID
26029367
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Robbins, Gregory R., Reid A. Roberts, Haitao Guo, Kevin Reuter, Tammy Shen, Gregory D. Sempowski, Karen P. McKinnon, Lishan Su, Joseph M. DeSimone, and Jenny P-Y Ting. “Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model.” Nanomedicine 11, no. 3 (April 2015): 589–99. https://doi.org/10.1016/j.nano.2014.11.010.

PMID
25596079
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Fusco, William G., Neelima R. Choudhary, Shelley M. Stewart, S Munir Alam, Gregory D. Sempowski, Christopher Elkins, and Isabelle Leduc. “Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.” Monoclon Antib Immunodiagn Immunother 34, no. 2 (April 2015): 73–82. https://doi.org/10.1089/mab.2014.0054.

PMID
25897604
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