Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Robbins, Gregory R., Reid A. Roberts, Haitao Guo, Kevin Reuter, Tammy Shen, Gregory D. Sempowski, Karen P. McKinnon, Lishan Su, Joseph M. DeSimone, and Jenny P-Y Ting. “Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model.” Nanomedicine 11, no. 3 (April 2015): 589–99. https://doi.org/10.1016/j.nano.2014.11.010.

PMID
25596079
Full Text

Fusco, William G., Neelima R. Choudhary, Shelley M. Stewart, S Munir Alam, Gregory D. Sempowski, Christopher Elkins, and Isabelle Leduc. “Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.” Monoclon Antib Immunodiagn Immunother 34, no. 2 (April 2015): 73–82. https://doi.org/10.1089/mab.2014.0054.

PMID
25897604
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Szabolcs, Paul, Rebecca H. Buckley, Robert Duane Davis, Jerelyn Moffet, Judith Voynow, Jeyaraj Antony, Xiaohua Chen, Gregory D. Sempowski, and David W. Zaas. “Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor.” J Allergy Clin Immunol 135, no. 2 (February 2015): 567–70. https://doi.org/10.1016/j.jaci.2014.07.058.

PMID
25262460
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Goldberg, Emily L., Melissa J. Romero-Aleshire, Kristin R. Renkema, Melissa S. Ventevogel, Wade M. Chew, Jennifer L. Uhrlaub, Megan J. Smithey, et al. “Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.” Aging Cell 14, no. 1 (February 2015): 130–38. https://doi.org/10.1111/acel.12280.

PMID
25424641
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Callaway, Justin B., Scott A. Smith, Douglas G. Widman, Karen P. McKinnon, Frank Scholle, Gregory D. Sempowski, Dirk P. Dittmer, James E. Crowe, Aravinda M. de Silva, and Jenny P-Y Ting. “Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.” Plos One 10, no. 8 (2015): e0136708. https://doi.org/10.1371/journal.pone.0136708.

PMID
26301593
Full Text

Pugh, Jason L., Alona S. Sukhina, Thomas M. Seed, Nancy R. Manley, Gregory D. Sempowski, Marcel R. M. van den Brink, Megan J. Smithey, and Janko Nikolich-Žugich. “Histone deacetylation critically determines T cell subset radiosensitivity.” J Immunol 193, no. 3 (August 1, 2014): 1451–58. https://doi.org/10.4049/jimmunol.1400434.

PMID
24990082
Full Text

Lynch, Heather E., Ana M. Sanchez, M Patricia D’Souza, Wes Rountree, Thomas N. Denny, Michael Kalos, and Gregory D. Sempowski. “Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays.” J Immunol Methods 409 (July 2014): 62–71. https://doi.org/10.1016/j.jim.2014.04.011.

PMID
24801479
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Fusco, William G., Neelima R. Choudhary, Patty A. Routh, Melissa S. Ventevogel, Valerie A. Smith, Gary G. Koch, Glen W. Almond, Paul E. Orndorff, Gregory D. Sempowski, and Isabelle Leduc. “The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid.” Vaccine 32, no. 30 (June 24, 2014): 3752–58. https://doi.org/10.1016/j.vaccine.2014.05.031.

PMID
24844153
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Roberts, Lydia M., John S. Davies, Gregory D. Sempowski, and Jeffrey A. Frelinger. “IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.” Vaccine 32, no. 29 (June 17, 2014): 3595–3603. https://doi.org/10.1016/j.vaccine.2014.05.013.

PMID
24837506
Full Text

Roberts, Lydia M., Shraddha Tuladhar, Shaun P. Steele, Kristina J. Riebe, Ching-Ju Chen, R Ian Cumming, Sarah Seay, et al. “Identification of early interactions between Francisella and the host.” Infect Immun 82, no. 6 (June 2014): 2504–10. https://doi.org/10.1128/IAI.01654-13.

PMID
24686053
Full Text

Pages