Hope Elizabeth Uronis, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 435 Seeley G. Mudd Building, Box 2823, Durham, NC 27710
Phone (919) 681-3480
In Their Words

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 2005 - 2007
  • Chief Medical Resident -Duke Hospital, Medicine, Duke University, 2004 - 2005
  • Fellow in Hematology-Oncology, Medicine, Duke University, 2003 - 2004
  • Medical Resident, Medicine, Duke University, 2000 - 2003
  • M.D., State University of New York at Buffalo, 2000

Publications

Cinar, Pelin, Timothy Kubal, Alison Freifeld, Asmita Mishra, Lawrence Shulman, James Bachman, Rafael Fonseca, et al. “Safety at the Time of the COVID-19 Pandemic: How to Keep our Oncology Patients and Healthcare Workers Safe.” J Natl Compr Canc Netw, April 15, 2020, 1–6. https://doi.org/10.6004/jnccn.2020.7572.

PMID
32294617
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Strickler, John H., Christel N. Rushing, Donna Niedzwiecki, Abigail McLeod, Ivy Altomare, Hope E. Uronis, S David Hsu, et al. “A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer.” Bmc Cancer 19, no. 1 (November 1, 2019): 1032. https://doi.org/10.1186/s12885-019-6234-8.

PMID
31675952
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Clarke, Jeffrey Melson, Gerard C. Blobe, John H. Strickler, Hope Elizabeth Uronis, S Yousuf Zafar, Michael Morse, Evan Dropkin, et al. “A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial).” Cancer Chemother Pharmacol 84, no. 4 (October 2019): 909–17. https://doi.org/10.1007/s00280-019-03916-0.

PMID
31444620
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Mettu, Niharika B., Donna Niedzwiecki, Christel Rushing, Andrew B. Nixon, Jingquan Jia, Sherri Haley, Wanda Honeycutt, Herbert Hurwitz, Johanna C. Bendell, and Hope Uronis. “A phase I study of gemcitabine + dasatinib (gd) or gemcitabine + dasatinib + cetuximab (GDC) in refractory solid tumors.” In Cancer Chemother Pharmacol, 83:1025–35, 2019. https://doi.org/10.1007/s00280-019-03805-6.

PMID
30895346
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Catenacci, D. V. T., H. Park, H. E. Uronis, Y. -. K. Kang, M. Ng, P. Gold, J. Lacy, et al. “Biomarker-guided enrichment of the antitumor activity of margetuximab (M) plus pembrolizumab (P) in patients with advanced HER2+ gastric adenocarcinoma (GEA).” In Ann Oncol, 29 Suppl 8:viii223, 2018. https://doi.org/10.1093/annonc/mdy282.046.

PMID
32136480
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Wang, J., S. V. Liu, H. E. Uronis, C. Wu, D. Mahalingam, A. Spira, L. Carter, et al. “Novel small-molecule RORγ agonist immuno-oncology agent LYC-55716: Safety and efficacy in a phase IIA open-label, multicenter trial.” In Ann Oncol, 29 Suppl 8:viii404–5, 2018. https://doi.org/10.1093/annonc/mdy288.012.

PMID
32137012
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Sohal, Davendra P. S., Erin B. Kennedy, Alok Khorana, Mehmet S. Copur, Christopher H. Crane, Ignacio Garrido-Laguna, Smitha Krishnamurthi, et al. “Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update.” J Clin Oncol 36, no. 24 (August 20, 2018): 2545–56. https://doi.org/10.1200/JCO.2018.78.9636.

PMID
29791286
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Vlahovic, Gordana, Kellen L. Meadows, Ace J. Hatch, Jingquan Jia, Andrew B. Nixon, Hope E. Uronis, Michael A. Morse, et al. “A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer.” Oncologist 23, no. 7 (July 2018): 782–90. https://doi.org/10.1634/theoncologist.2016-0377.

PMID
29572245
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Palta, Manisha, Brian G. Czito, Eileen Duffy, Mary Malicki, Donna Niedzwiecki, James L. Abbruzzese, Hope Elizabeth Uronis, Gerard C. Blobe, Dan G. Blazer, and Christopher Willett. “A phase II trial of neoadjuvant gemcitabine/nab-paclitaxel and SBRT for potentially resectable pancreas cancer: An evaluation of acute toxicity.” In Journal of Clinical Oncology, 36:4121–4121. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.4121.

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Kelly, Karen, Melissa Lynne Johnson, Devalingam Mahalingam, Stephen V. Liu, Hope Elizabeth Uronis, Christina Wu, Laura Carter, et al. “A phase 2A open-label, multicenter trial of the safety and efficacy of LYC-55716, a first-in-class oral, small-molecule RORγ agonist to treat select solid tumors.” In Journal of Clinical Oncology, 36:TPS2617–TPS2617. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.tps2617.

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