Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Wang, J, Hanada, K, Staus, DP, Makara, MA, Dahal, GR, Chen, Q, Ahles, A, Engelhardt, S, and Rockman, HA. "Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling." Nature Communications 8, no. 1 (November 22, 2017): 1706-.

PMID
29167435
Full Text

Abraham, DM, Davis, RT, Warren, CM, Mao, L, Wolska, BM, Solaro, RJ, and Rockman, HA. "β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility." Proceedings of the National Academy of Sciences of the United States of America 113, no. 50 (December 2016): 14426-14431.

PMID
27911784
Full Text

Watson, LJ, Alexander, KM, Mohan, ML, Bowman, AL, Mangmool, S, Xiao, K, Naga Prasad, SV, and Rockman, HA. "Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation." Cellular signalling 28, no. 10 (October 2016): 1580-1592.

PMID
27169346
Full Text

Hodavance, SY, Gareri, C, Torok, RD, and Rockman, HA. "G Protein-coupled Receptor Biased Agonism." Journal of cardiovascular pharmacology 67, no. 3 (March 2016): 193-202. (Review)

PMID
26751266
Full Text

Wisler, JW, Harris, EM, Raisch, M, Mao, L, Kim, J, Rockman, HA, and Lefkowitz, RJ. "The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome." American Journal of Physiology - Heart and Circulatory Physiology 309, no. 9 (November 2015): H1516-H1527.

PMID
26371162
Full Text

Xu, W, Barrientos, T, Mao, L, Rockman, HA, Sauve, AA, and Andrews, NC. "Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart." Cell reports 13, no. 3 (October 7, 2015): 533-545.

PMID
26456827
Full Text

Pironti, G, Strachan, RT, Abraham, D, Mon-Wei Yu, S, Chen, M, Chen, W, Hanada, K, Mao, L, Watson, LJ, and Rockman, HA. "Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors." Circulation 131, no. 24 (June 2015): 2120-2130.

PMID
25995315
Full Text

Lee, TE, Yu, L, Wolf, MJ, and Rockman, HA. "Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila." Genetics 198, no. 2 (October 2014): 591-603.

PMID
25081566
Full Text

Tang, W, Strachan, RT, Lefkowitz, RJ, and Rockman, HA. "Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch." The Journal of biological chemistry 289, no. 41 (October 2014): 28271-28283.

PMID
25170081
Full Text

Rockman, HA. "Happy birthday JCI." The Journal of clinical investigation 124, no. 10 (October 2014): 4135-4136.

PMID
25271720
Full Text

Pages