Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., Mc Gill University (Canada), 1983

Publications

Lee, TE, Yu, L, Wolf, MJ, and Rockman, HA. "Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila." Genetics 198, no. 2 (October 2014): 591-603.

PMID
25081566
Full Text

Tang, W, Strachan, RT, Lefkowitz, RJ, and Rockman, HA. "Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch." The Journal of biological chemistry 289, no. 41 (October 2014): 28271-28283.

PMID
25170081
Full Text

Kim, I, Wang, Y, Park, K, Tang, Y, Teoh, J, Vinson, J, Traynham, CJ, Pironti, G, Mao, L, Su, H, Johnson, JA, Koch, W, and Rockman, HA. "β-arrestin1-biased β1-adrenergic receptor signaling regulates MicroRNA processing." Circulation Research 114, no. 5 (February 28, 2014): 833-844.

Full Text

Kim, IM, Wang, Y, Park, KM, Tang, Y, Teoh, JP, Vinson, J, Traynham, CJ, Pironti, G, Mao, L, Su, H, Johnson, JA, Koch, WJ, and Rockman, HA. "β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing." Circ Res 114, no. 5 (February 28, 2014): 833-844.

PMID
24334028
Full Text

Rockman, HA. "Waste not, want not." The Journal of clinical investigation 124, no. 2 (February 2014): 463-.

PMID
24487638
Full Text

Santacruz, L, Hernandez, A, Nienaber, J, Mishra, R, Pinilla, M, Burchette, J, Mao, L, Rockman, HA, and Jacobs, DO. "Normal cardiac function in mice with supraphysiological cardiac creatine levels." Am J Physiol Heart Circ Physiol 306, no. 3 (February 2014): H373-H381.

PMID
24271489
Full Text

Ashton, JR, Befera, N, Clark, D, Qi, Y, Mao, L, Rockman, HA, Johnson, GA, and Badea, CT. "Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent." Contrast media & molecular imaging 9, no. 2 (2014): 161-168.

PMID
24523061
Full Text

Rockman, HA. "Tempus fugit." J Clin Invest 123, no. 3 (March 1, 2013): 935-936.

PMID
23454753
Full Text

Tang, H, Xiao, K, Mao, L, Rockman, HA, and Marchuk, DA. "Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction." J Mol Cell Cardiol 54 (January 2013): 101-111.

PMID
23085512
Full Text

Tang, H, Xiao, K, Mao, L, Rockman, HA, and Marchuk, DA. "Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction." Journal of Molecular and Cellular Cardiology 54, no. 1 (2013): 101-111.

Full Text

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