Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Bishawi, Muath, Franklin H. Lee, Dennis M. Abraham, Carolyn Glass, Stephanie J. Blocker, Daniel J. Cox, Zachary D. Brown, et al. “Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.” Iscience 25, no. 4 (April 15, 2022): 104086. https://doi.org/10.1016/j.isci.2022.104086.

PMID
35378858
Full Text

Wang, Jialu, Biswaranjan Pani, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai, Haoran Jiang, Seungkirl Ahn, Robert J. Lefkowitz, and Howard A. Rockman. “β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.” Mol Pharmacol 100, no. 6 (December 2021): 568–79. https://doi.org/10.1124/molpharm.121.000359.

PMID
34561298
Full Text

Pfeiffer, Conrad T., Jialu Wang, Joao A. Paulo, Xue Jiang, Steven P. Gygi, and Howard A. Rockman. “Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists.” J Proteome Res 20, no. 6 (June 4, 2021): 3256–67. https://doi.org/10.1021/acs.jproteome.1c00080.

PMID
33950683
Full Text

McMahon, Conor, Dean P. Staus, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Matthias Elgeti, Wayne L. Hubbell, Howard A. Rockman, Andrew C. Kruse, and Robert J. Lefkowitz. “Synthetic nanobodies as angiotensin receptor blockers.” Proc Natl Acad Sci U S A 117, no. 33 (August 18, 2020): 20284–91. https://doi.org/10.1073/pnas.2009029117.

PMID
32753386
Full Text

Kim, Jihee, Chad A. Grotegut, James W. Wisler, Lan Mao, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.” Proc Natl Acad Sci U S A 117, no. 22 (June 2, 2020): 12435–43. https://doi.org/10.1073/pnas.1920310117.

PMID
32414934
Full Text

Nielsen, Natalie R., Krsna V. Rangarajan, Lan Mao, Howard A. Rockman, and Kathleen M. Caron. “A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis.” Am J Physiol Heart Circ Physiol 318, no. 4 (April 1, 2020): H895–907. https://doi.org/10.1152/ajpheart.00436.2019.

PMID
32142379
Full Text

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