Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Wisler, JW, Rockman, HA, and Lefkowitz, RJ. "Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery." Circulation 137, no. 22 (May 2018): 2315-2317.

PMID
29844068
Full Text

Wang, J, Hanada, K, Gareri, C, and Rockman, HA. "Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling." Journal of Cellular Biochemistry 119, no. 4 (April 2018): 3586-3597.

PMID
29231251
Full Text

Wang, J, Hanada, K, Staus, DP, Makara, MA, Dahal, GR, Chen, Q, Ahles, A, Engelhardt, S, and Rockman, HA. "Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling." Nature communications 8, no. 1 (November 22, 2017): 1706-.

PMID
29167435
Full Text

Jean-Charles, P-Y, Yu, SM-W, Abraham, D, Kommaddi, RP, Mao, L, Strachan, RT, Zhang, Z-S, Bowles, DE, Brian, L, Stiber, JA, Jones, SN, Koch, WJ, Rockman, HA, and Shenoy, SK. "Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling." JCI insight 2, no. 17 (September 7, 2017).

PMID
28878120
Full Text

Abraham, DM, Davis, RT, Warren, CM, Mao, L, Wolska, BM, Solaro, RJ, and Rockman, HA. "β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility." Proceedings of the National Academy of Sciences of the United States of America 113, no. 50 (December 2016): 14426-14431.

PMID
27911784
Full Text

Watson, LJ, Alexander, KM, Mohan, ML, Bowman, AL, Mangmool, S, Xiao, K, Naga Prasad, SV, and Rockman, HA. "Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation." Cellular Signalling 28, no. 10 (October 2016): 1580-1592.

PMID
27169346
Full Text

Hodavance, SY, Gareri, C, Torok, RD, and Rockman, HA. "G Protein-coupled Receptor Biased Agonism." Journal of cardiovascular pharmacology 67, no. 3 (March 2016): 193-202. (Review)

PMID
26751266
Full Text

Rockman, HA. "New kid on the block." The Journal of clinical investigation 126, no. 1 (January 2016): 1-2.

PMID
26627869
Full Text

Kirk, JA, Chakir, K, Lee, KH, Karst, E, Holewinski, RJ, Pironti, G, Tunin, RS, Pozios, I, Abraham, TP, de Tombe, P, Rockman, HA, Van Eyk, JE, Craig, R, Farazi, TG, and Kass, DA. "Pacemaker-induced transient asynchrony suppresses heart failure progression." Science Translational Medicine 7, no. 319 (December 2015): 319ra207-null.

PMID
26702095
Full Text

Wisler, JW, Harris, EM, Raisch, M, Mao, L, Kim, J, Rockman, HA, and Lefkowitz, RJ. "The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome." American Journal of Physiology. Heart and Circulatory Physiology 309, no. 9 (November 2015): H1516-H1527.

PMID
26371162
Full Text

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