Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure
Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.
Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.
2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.
3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .
Education and Training
- Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
- Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
- M.D., McGill University (Canada), 1983
- Duke CTSA (KL2)
- Duke CTSA (TL1)
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Mycocardial Fuel Section
- Duke Resident Physician-Scientist Program- NHLBI
- Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation
- Duke Training Grant in Nephrology
- Copper Homeostasis in Mammals
- Multidisciplinary Heart and Vascular Diseases
- Organization and Function of Cellular Structure
- Novel Mechanisms and Therapies in Heart Failure
- TREK-1 in fibroblast differentiation and cardiac fibrosis development
- Paracrine Control of Blood Pressure by Renal Intercalated Cells
- Interdisciplinary Training Program in Lung Disease
- Integrated Cellular and Tissue Engineering for Ischemic Heart Disease
- Mechanisms of Maladaptation in Heart Failure
- Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart