Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Bhargava, V., G. Hagan, M. I. Miyamoto, S. Ono, H. Rockman, and J. Ross. “Systolic and diastolic global right and left ventricular function assessment in small animals using an automated angiographic technique.” In Proceedings  Computers in Cardiology, Cic 1992, 191–94, 1992. https://doi.org/10.1109/CIC.1992.269414.

Full Text

Miyamoto, M. I., H. A. Rockman, B. D. Guth, G. Heusch, and J. Ross. “Effect of alpha-adrenergic stimulation on regional contractile function and myocardial blood flow with and without ischemia.” Circulation 84, no. 4 (October 1991): 1715–24. https://doi.org/10.1161/01.cir.84.4.1715.

PMID
1680577
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Rockman, H. A., R. S. Ross, A. N. Harris, K. U. Knowlton, M. E. Steinhelper, L. J. Field, J. Ross, and K. R. Chien. “Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.” Proc Natl Acad Sci U S A 88, no. 18 (September 15, 1991): 8277–81. https://doi.org/10.1073/pnas.88.18.8277.

PMID
1832775
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Rockman, H. A., R. M. Adamson, W. P. Dembitsky, J. W. Bonar, and B. E. Jaski. “Acute fulminant myocarditis: long-term follow-up after circulatory support with left ventricular assist device.” Am Heart J 121, no. 3 Pt 1 (March 1991): 922–26. https://doi.org/10.1016/0002-8703(91)90213-2.

PMID
2000764
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Rockman, H. A., R. S. Ross, A. N. Harris, K. U. Knowlton, M. E. Steinhelper, L. J. Field, J. Ross, and K. R. Chien. “Erratum: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy (Proc. Natl. Acad. Sci. USA (September 1991) 88 (8277-8281)).” Proceedings of the National Academy of Sciences of the United States of America 88, no. 21 (January 1, 1991): 9907. https://doi.org/10.1073/pnas.88.21.9907a.

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Rockman, H. A., C. Juneau, K. Chatterjee, and J. L. Rouleau. “Long-term predictors of sudden and low output death in chronic congestive heart failure secondary to coronary artery disease.” Am J Cardiol 64, no. 19 (December 1, 1989): 1344–48. https://doi.org/10.1016/0002-9149(89)90579-1.

PMID
2589201
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Germinario, R. J., H. Rockman, M. Oliveira, S. Manuel, and M. Taylor. “Regulation of sugar transport in cultured diploid human skin fibroblasts.” J Cell Physiol 112, no. 3 (September 1982): 367–72. https://doi.org/10.1002/jcp.1041120309.

PMID
6182150
Full Text

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