Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Matthew J. Wolf, and Howard A. Rockman. “TREK-1 Modulates Fibrosis & Diastolic Dysfunction Through Activation of Stress-Activated Kinases.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.

Scholars@Duke

Tang, Wei, Ryan T. Strachan, Robert J. Lefkowitz, and Howard A. Rockman. “Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.” J Biol Chem 289, no. 41 (October 10, 2014): 28271–83. https://doi.org/10.1074/jbc.M114.585067.

PMID
25170081
Full Text

Lee, Teresa E., Lin Yu, Matthew J. Wolf, and Howard A. Rockman. “Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila.” Genetics 198, no. 2 (October 2014): 591–603. https://doi.org/10.1534/genetics.114.166777.

PMID
25081566
Full Text

Ashton, Jeffrey R., Nicholas Befera, Darin Clark, Yi Qi, Lan Mao, Howard A. Rockman, G Allan Johnson, and Cristian T. Badea. “Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.” Contrast Media Mol Imaging 9, no. 2 (March 2014): 161–68. https://doi.org/10.1002/cmmi.1557.

PMID
24523061
Full Text

Kim, Il-Man, Yongchao Wang, Kyoung-Mi Park, Yaoping Tang, Jian-Peng Teoh, Joseph Vinson, Christopher J. Traynham, et al. “β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.” Circ Res 114, no. 5 (February 28, 2014): 833–44. https://doi.org/10.1161/CIRCRESAHA.114.302766.

PMID
24334028
Full Text

Santacruz, Lucia, Alejandro Hernandez, Jeffrey Nienaber, Rajashree Mishra, Miguel Pinilla, James Burchette, Lan Mao, Howard A. Rockman, and Danny O. Jacobs. “Normal cardiac function in mice with supraphysiological cardiac creatine levels.” Am J Physiol Heart Circ Physiol 306, no. 3 (February 2014): H373–81. https://doi.org/10.1152/ajpheart.00411.2013.

PMID
24271489
Full Text

Kim, Il-Man, Yongchao Wang, Kyoung-mi Park, Christopher J. Traynham, Lan Mao, Walter J. Koch, and Howard A. Rockman. “beta-arrestin1-Biased beta 1-adrenergic Receptor Signaling Regulates MicroRNA Processing.” In Circulation Research, Vol. 113. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Pages