Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Houser, SR, Margulies, KB, Murphy, AM, Spinale, FG, Francis, GS, Prabhu, SD, Rockman, HA, Kass, DA, Molkentin, JD, Sussman, MA, and Koch, W. "Animal models of heart failure: A scientific statement from the american heart association." Circulation Research (2012).

Full Text

Casad, ME, Abraham, D, Kim, I-M, Frangakis, S, Dong, B, Lin, N, Wolf, MJ, and Rockman, HA. "Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster." Genetics 189, no. 3 (November 2011): 861-870.

PMID
21890737
Full Text

Noor, N, Patel, CB, and Rockman, HA. "Β-arrestin: a signaling molecule and potential therapeutic target for heart failure." J Mol Cell Cardiol 51, no. 4 (October 2011): 534-541. (Review)

PMID
21074538
Full Text

Shenoy, SK, and Rockman, HA. "Cardiovascular biology: heart fails without pump partner. (Published online)" Nature 477, no. 7366 (September 28, 2011): 546-547.

PMID
21956327
Full Text

Wolf, MJ, and Rockman, HA. "Drosophila, genetic screens, and cardiac function." Circ Res 109, no. 7 (September 16, 2011): 794-806. (Review)

PMID
21921272
Full Text

Rockman, HA, and Lefkowitz, RJ. "Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling." Circ Res 109, no. 2 (July 8, 2011): 202-204.

PMID
21737815
Full Text

Lin, N, Badie, N, Yu, L, Abraham, D, Cheng, H, Bursac, N, Rockman, HA, and Wolf, MJ. "A method to measure myocardial calcium handling in adult Drosophila." Circ Res 108, no. 11 (May 27, 2011): 1306-1315.

PMID
21493892
Full Text

Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477.

PMID
21139074
Full Text

Patel, CB, Noor, N, and Rockman, HA. "Functional selectivity in adrenergic and angiotensin signaling systems." Mol Pharmacol 78, no. 6 (December 2010): 983-992. (Review)

PMID
20855464
Full Text

Alexander, KM, Mangmool, S, Patel, CB, Xiao, K, and Rockman, HA. "Phosphoinositde 3-Kinase Regulates beta 2-Adrenergic Receptor Stimulated Epidermal Growth Factor Receptor Transactivation." CIRCULATION 122, no. 21 (November 23, 2010).

Scholars@Duke

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