James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Grunewald, R., H. Kantarjian, M. J. Keating, J. Abbruzzese, P. Tarassoff, and W. Plunkett. “Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia..” Cancer Res 50, no. 21 (November 1, 1990): 6823–26.

PMID
2208147
Scholars@Duke

Abbruzzese, J. L., B. Levin, J. A. Ajani, J. S. Faintuch, R. Pazdur, S. Saks, C. Edwards, and J. U. Gutterman. “A phase II trial of recombinant human interferon-gamma and recombinant tumor necrosis factor in patients with advanced gastrointestinal malignancies: results of a trial terminated by excessive toxicity..” J Biol Response Mod 9, no. 5 (October 1990): 522–27.

PMID
2123922
Scholars@Duke

Frost, P., J. L. Abbruzzese, B. Hunt, D. Lee, and M. Ellis. “Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells..” Cancer Res 50, no. 15 (August 1, 1990): 4572–77.

PMID
1695122
Scholars@Duke

Ajani, J. A., J. A. Roth, B. Ryan, M. McMurtrey, T. A. Rich, D. E. Jackson, J. L. Abbruzzese, B. Levin, L. DeCaro, and C. Mountain. “Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction..” J Clin Oncol 8, no. 7 (July 1990): 1231–38. https://doi.org/10.1200/JCO.1990.8.7.1231.

PMID
2358838
Full Text

Ajani, J. A., J. L. Abbruzzese, J. S. Faintuch, Y. Z. Patt, B. M. Boman, D. E. Jackson, B. Levin, and I. H. Krakoff. “A phase II study of trimetrexate therapy for metastatic colorectal carcinoma..” Cancer Invest 8, no. 6 (1990): 619–21.

PMID
2149834
Scholars@Duke

Abbruzzese, J. L., R. Amato, S. Schmidt, M. N. Raber, and P. Frost. “Phase I clinical trial of cisplatin given i.v. with 5-fluorouracil and high-dose folinic acid..” Cancer Chemother Pharmacol 26, no. 3 (1990): 159–62. https://doi.org/10.1007/bf02897192.

PMID
2357761
Full Text

Ajani, J. A., D. M. Ota, V. B. Grossie, J. L. Abbruzzese, J. S. Faintuch, Y. Z. Patt, D. E. Jackson, B. Levin, and K. Nishioka. “Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma..” Cancer Chemother Pharmacol 26, no. 3 (1990): 223–26. https://doi.org/10.1007/bf02897204.

PMID
2113439
Full Text

Abbruzzese, J. L., A. Weeks, M. N. Raber, D. Gravel, R. A. DuBrow, B. Levin, J. Grem, and H. G. Chun. “Phase I trial of semustine plus weekly fluorouracil and high-dose leucovorin calcium in patients with advanced colorectal cancer..” J Natl Cancer Inst 81, no. 23 (December 6, 1989): 1840–42. https://doi.org/10.1093/jnci/81.23.1840.

PMID
2585532
Full Text

Weeks, A. E., J. L. Abbruzzese, and B. Levin. “Current status of chemotherapy for colorectal cancer.” Drug Therapy 19, no. 6 (December 1, 1989): 36–55.

Scholars@Duke

Abbruzzese, J. L., B. Levin, J. A. Ajani, J. S. Faintuch, S. Saks, Y. Z. Patt, C. Edwards, K. Ende, and J. U. Gutterman. “Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer..” Cancer Res 49, no. 14 (July 15, 1989): 4057–61.

PMID
2500234
Scholars@Duke

Pages