James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Sadeghi, N, Abbruzzese, JL, Yeung, S-CJ, Hassan, M, and Li, D. "Metformin use is associated with better survival of diabetic patients with pancreatic cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 18, no. 10 (May 2012): 2905-2912.

PMID
22465831
Full Text

Chang, DZ, Ma, Y, Ji, B, Liu, Y, Hwu, P, Abbruzzese, JL, Logsdon, C, and Wang, H. "Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression." Journal of hematology & oncology 5 (April 4, 2012): 15-.

PMID
22475564
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Chatterjee, D, Rashid, A, Wang, H, Katz, MH, Wolff, RA, Varadhachary, GR, Lee, JE, Pisters, PW, Gomez, HF, Abbruzzese, JL, Fleming, JB, and Wang, H. "Tumor invasion of muscular vessels predicts poor prognosis in patients with pancreatic ductal adenocarcinoma who have received neoadjuvant therapy and pancreaticoduodenectomy." The American journal of surgical pathology 36, no. 4 (April 2012): 552-559.

PMID
22301496
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Dong, X, Li, Y, Tang, H, Chang, P, Hess, KR, Abbruzzese, JL, and Li, D. "Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer." Cancer epidemiology 36, no. 2 (April 2012): 206-211.

PMID
21852217
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Kaseb, AO, Morris, JS, Hassan, MM, and Abbruzzese, JL. "Reply to A. Goyal et al." Journal of Clinical Oncology 30, no. 9 (March 20, 2012): 1019-1020.

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Chatterjee, D, Katz, MH, Rashid, A, Wang, H, Iuga, AC, Varadhachary, GR, Wolff, RA, Lee, JE, Pisters, PW, Crane, CH, Gomez, HF, Abbruzzese, JL, Fleming, JB, and Wang, H. "Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma." The American journal of surgical pathology 36, no. 3 (March 2012): 409-417.

PMID
22301497
Full Text

Dakik, HK, Moskovic, DJ, Carlson, PJ, Tamm, EP, Qiao, W, Wolff, RA, Abbruzzese, JL, and Fogelman, DR. "The use of GTX as second-line and later chemotherapy for metastatic pancreatic cancer: a retrospective analysis." Cancer chemotherapy and pharmacology 69, no. 2 (February 2012): 425-430.

PMID
21850466
Full Text

Hammond-Thelin, LA, Thomas, MB, Iwasaki, M, Abbruzzese, JL, Lassere, Y, Meyers, CA, Hoff, P, de Bono, J, Norris, J, Matsushita, H, Mita, A, and Rowinsky, EK. "Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies." Investigational new drugs 30, no. 1 (February 2012): 316-326.

PMID
20839029
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Kaseb, AO, Garrett-Mayer, E, Morris, JS, Xiao, L, Lin, E, Onicescu, G, Hassan, MM, Hassabo, HM, Iwasaki, M, Deaton, FL, Abbruzzese, JL, and Thomas, MB. "Efficacy of bevacizumab plus erlotinib for advanced hepatocellular carcinoma and predictors of outcome: final results of a phase II trial." Oncology 82, no. 2 (January 2012): 67-74.

PMID
22327795
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Zhao, Q, Rashid, A, Gong, Y, Katz, MH, Lee, JE, Wolf, R, Balachandran, A, Varadhachary, GR, Pisters, PW, Wang, H, Gomez, HF, Abbruzzese, JL, Fleming, JB, and Wang, H. "Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with a better prognosis." Annals of diagnostic pathology 16, no. 1 (January 2012): 29-37.

PMID
22050964
Full Text

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