James Abbruzzese, MD

Professor of Medicine
D. C. I. Distinguished Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., The University of Chicago, 1978

Publications

Abbott, Daniel E., Ching-Wei David Tzeng, Ryan P. Merkow, Scott B. Cantor, George J. Chang, Matthew Harold Katz, David J. Bentrem, et al. “The cost-effectiveness of neoadjuvant chemoradiation is superior to a surgery-first approach in the treatment of pancreatic head adenocarcinoma.” Ann Surg Oncol 20 Suppl 3 (December 2013): S500–508. https://doi.org/10.1245/s10434-013-2882-0.

PMID
23397153
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Luo, Yongde, Chaofeng Yang, Min Ye, Chengliu Jin, James L. Abbruzzese, Mong-Hong Lee, Sai-Ching J. Yeung, and Wallace L. McKeehan. “Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.” Cancer Metab 1, no. 1 (November 25, 2013): 21. https://doi.org/10.1186/2049-3002-1-21.

PMID
24279986
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Stuti, S., S. Shroff, M. J. Overman, A. Rashid, R. T. Shroff, H. Wang, D. Chatterjee, et al. “The expression of pten is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy.” Archives of Pathology and Laboratory Medicine 137, no. 11 (November 1, 2013): 1619–26. https://doi.org/10.5858/arpa.2012-0418-OA).

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Shroff, Stuti, Michael J. Overman, Asif Rashid, Rachna T. Shroff, Hua Wang, Deyali Chatterjee, Matthew H. Katz, et al. “The expression of PTEN is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy.” Arch Pathol Lab Med 137, no. 11 (November 2013): 1619–26. https://doi.org/10.5858/arpa.2012-0418-OA.

PMID
24168499
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Hassan, Manal M., Ahmed Kaseb, Carol J. Etzel, Hashem El-Serag, Margaret R. Spitz, Ping Chang, Katherine S. Hale, et al. “Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction.” Mol Carcinog 52 Suppl 1 (November 2013): E139–47. https://doi.org/10.1002/mc.22057.

PMID
23776098
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Khalil, Mohamed A., Wei Qiao, Peter Carlson, Binsah George, Milind Javle, Michael Overman, Gauri Varadhachary, Robert A. Wolff, James L. Abbruzzese, and David R. Fogelman. “The addition of erlotinib to gemcitabine and cisplatin does not appear to improve median survival in metastatic pancreatic cancer.” Invest New Drugs 31, no. 5 (October 2013): 1375–83. https://doi.org/10.1007/s10637-013-9967-2.

PMID
23645398
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Kaseb, Ahmed O., Junichi Shindoh, Yehuda Z. Patt, Robert E. Roses, Giuseppe Zimmitti, Richard D. Lozano, Manal M. Hassan, et al. “Modified cisplatin/interferon α-2b/doxorubicin/5-fluorouracil (PIAF) chemotherapy in patients with no hepatitis or cirrhosis is associated with improved response rate, resectability, and survival of initially unresectable hepatocellular carcinoma.” Cancer 119, no. 18 (September 15, 2013): 3334–42. https://doi.org/10.1002/cncr.28209.

PMID
23821538
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Overman, M. J., J. Zhang, S. Kopetz, M. Davies, Z. Q. Jiang, K. Stemke-Hale, P. Rümmele, et al. “Erratum: Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome (PLoS ONE (2013) 8:7 DOI: 10.1371/annotation/6afdd046- e1a7-4421-b7ec-0c9492ce2544).” Plos One 8, no. 7 (July 3, 2013). https://doi.org/10.1371/annotation/6afdd046-e1a7-4421-b7ec-0c9492ce2544.

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Tzeng, Ching-Wei D., Daniel E. Abbott, Scott B. Cantor, Jason B. Fleming, Jeffrey E. Lee, Peter W. T. Pisters, Gauri R. Varadhachary, et al. “Frequency and intensity of postoperative surveillance after curative treatment of pancreatic cancer: a cost-effectiveness analysis.” Ann Surg Oncol 20, no. 7 (July 2013): 2197–2203. https://doi.org/10.1245/s10434-013-2889-6.

PMID
23408126
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Foo, Wai Chin, Asif Rashid, Hua Wang, Matthew H. Katz, Jeffrey E. Lee, Peter W. Pisters, Robert A. Wolff, James L. Abbruzzese, Jason B. Fleming, and Huamin Wang. “Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.” Hum Pathol 44, no. 6 (June 2013): 1024–30. https://doi.org/10.1016/j.humpath.2012.09.001.

PMID
23260327
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