James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Overman, Michael J., Jiexin Zhang, Scott Kopetz, Michael Davies, Zhi-Qin Jiang, Katherine Stemke-Hale, Petra Rümmele, et al. “Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome..” Plos One 8, no. 6 (2013). https://doi.org/10.1371/journal.pone.0065144.

PMID
23776447
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Katz, Matthew H. G., Jason B. Fleming, Priya Bhosale, Gauri Varadhachary, Jeffrey E. Lee, Robert Wolff, Huamin Wang, et al. “Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators..” Cancer 118, no. 23 (December 1, 2012): 5749–56. https://doi.org/10.1002/cncr.27636.

PMID
22605518
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Wang, Jiansheng, Jeannelyn S. Estrella, Lan Peng, Asif Rashid, Gauri R. Varadhachary, Hua Wang, Jeffrey E. Lee, et al. “Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation..” Cancer 118, no. 15 (August 1, 2012): 3801–11. https://doi.org/10.1002/cncr.26717.

PMID
22180096
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Weng, Shaofan, Hua Wang, Weihong Chen, Matthew H. Katz, Deyali Chatterjee, Jeffrey E. Lee, Peter W. Pisters, et al. “Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma..” Cancer Epidemiol Biomarkers Prev 21, no. 8 (August 2012): 1336–43. https://doi.org/10.1158/1055-9965.EPI-12-0223.

PMID
22665577
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Truty, Mark J., Ryan M. Thomas, Matthew H. Katz, Jean-Nicolas Vauthey, Christopher Crane, Gaury R. Varadhachary, Robert A. Wolff, James L. Abbruzzese, Jeffrey E. Lee, and Jason B. Fleming. “Multimodality therapy offers a chance for cure in patients with pancreatic adenocarcinoma deemed unresectable at first operative exploration..” J Am Coll Surg 215, no. 1 (July 2012): 41–51. https://doi.org/10.1016/j.jamcollsurg.2012.03.024.

PMID
22608401
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Chatterjee, Deyali, Matthew H. Katz, Asif Rashid, Gauri R. Varadhachary, Robert A. Wolff, Hua Wang, Jeffrey E. Lee, et al. “Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome..” Cancer 118, no. 12 (June 15, 2012): 3182–90. https://doi.org/10.1002/cncr.26651.

PMID
22028089
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Dong, Xiaoqun, Yanan Li, Ping Chang, Kenneth R. Hess, James L. Abbruzzese, and Donghui Li. “DNA mismatch repair network gene polymorphism as a susceptibility factor for pancreatic cancer..” Mol Carcinog 51, no. 6 (June 2012): 491–99. https://doi.org/10.1002/mc.20817.

PMID
21681824
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Sadeghi, Navid, James L. Abbruzzese, Sai-Ching J. Yeung, Manal Hassan, and Donghui Li. “Metformin use is associated with better survival of diabetic patients with pancreatic cancer..” Clin Cancer Res 18, no. 10 (May 15, 2012): 2905–12. https://doi.org/10.1158/1078-0432.CCR-11-2994.

PMID
22465831
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Overman, Michael J., Chung-Yuan Hu, Scott Kopetz, James L. Abbruzzese, Robert A. Wolff, and George J. Chang. “A population-based comparison of adenocarcinoma of the large and small intestine: insights into a rare disease..” Ann Surg Oncol 19, no. 5 (May 2012): 1439–45. https://doi.org/10.1245/s10434-011-2173-6.

PMID
22187121
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Tomblyn, Michael B., Bryan H. Goldman, Charles R. Thomas, Jacqueline K. Benedetti, Heinz-Josef Lenz, Vivek Mehta, Thaddeus Beeker, et al. “Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: a phase-II study of the SWOG (S0414)..” J Thorac Oncol 7, no. 5 (May 2012): 906–12. https://doi.org/10.1097/JTO.0b013e31824c7bed.

PMID
22481235
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Pages