James Abbruzzese, MD

Professor of Medicine
D. C. I. Distinguished Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., The University of Chicago, 1978

Publications

Chang, Zhe, Zhongkui Li, Xiaoyang Wang, Ya’an Kang, Yuhui Yuan, Jiangong Niu, Huamin Wang, et al. “Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.” Clin Cancer Res 19, no. 3 (February 1, 2013): 549–59. https://doi.org/10.1158/1078-0432.CCR-12-0032.

PMID
23340292
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Li, Lei, Mohammad Othman, Asif Rashid, Hua Wang, Zhaoshen Li, Matthew H. Katz, Jeffrey E. Lee, et al. “Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells.” Histopathology 62, no. 3 (February 2013): 465–71. https://doi.org/10.1111/his.12023.

PMID
23134473
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Yao, Yixin, Milind Suraokar, Bryant G. Darnay, Brett G. Hollier, Tattym E. Shaiken, Takayuki Asano, Chien-Hung Chen, et al. “BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.” Sci Signal 6, no. 257 (January 8, 2013): ra2. https://doi.org/10.1126/scisignal.2003295.

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23300339
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Kaseb, Ahmed O., Mohamed Shama, Ibrahim Halil Sahin, Ajay Nooka, Hesham M. Hassabo, Jean-Nicolas Vauthey, Thomas Aloia, et al. “Prognostic indicators and treatment outcome in 94 cases of fibrolamellar hepatocellular carcinoma.” Oncology 85, no. 4 (2013): 197–203. https://doi.org/10.1159/000354698.

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24051705
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Overman, Michael J., Jiexin Zhang, Scott Kopetz, Michael Davies, Zhi-Qin Jiang, Katherine Stemke-Hale, Petra Rümmele, et al. “Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome.” Plos One 8, no. 6 (2013): e65144. https://doi.org/10.1371/journal.pone.0065144.

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23776447
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Overman, Michael J., Janhavi Modak, Scott Kopetz, Ravi Murthy, James C. Yao, Marshall E. Hicks, James L. Abbruzzese, and Alda L. Tam. “Use of research biopsies in clinical trials: are risks and benefits adequately discussed?” J Clin Oncol 31, no. 1 (January 1, 2013): 17–22. https://doi.org/10.1200/JCO.2012.43.1718.

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23129736
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Katz, Matthew H. G., Jason B. Fleming, Priya Bhosale, Gauri Varadhachary, Jeffrey E. Lee, Robert Wolff, Huamin Wang, et al. “Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators.” Cancer 118, no. 23 (December 1, 2012): 5749–56. https://doi.org/10.1002/cncr.27636.

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22605518
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Sahin, Ibrahim Halil, Mohamed A. Shama, Motofumi Tanaka, James L. Abbruzzese, Steven A. Curley, Manal Hassan, and Donghui Li. “Association of diabetes and perineural invasion in pancreatic cancer.” Cancer Med 1, no. 3 (December 2012): 357–62. https://doi.org/10.1002/cam4.43.

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23342285
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Wang, Jiansheng, Jeannelyn S. Estrella, Lan Peng, Asif Rashid, Gauri R. Varadhachary, Hua Wang, Jeffrey E. Lee, et al. “Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation.” Cancer 118, no. 15 (August 1, 2012): 3801–11. https://doi.org/10.1002/cncr.26717.

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22180096
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Weng, Shaofan, Hua Wang, Weihong Chen, Matthew H. Katz, Deyali Chatterjee, Jeffrey E. Lee, Peter W. Pisters, et al. “Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma.” Cancer Epidemiol Biomarkers Prev 21, no. 8 (August 2012): 1336–43. https://doi.org/10.1158/1055-9965.EPI-12-0223.

PMID
22665577
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Pages