James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Hammond-Thelin, LA, Thomas, MB, Iwasaki, M, Abbruzzese, JL, Lassere, Y, Meyers, CA, Hoff, P, de Bono, J, Norris, J, Matsushita, H, Mita, A, and Rowinsky, EK. "Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies." Investigational new drugs 30, no. 1 (February 2012): 316-326.

PMID
20839029
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Kaseb, AO, Garrett-Mayer, E, Morris, JS, Xiao, L, Lin, E, Onicescu, G, Hassan, MM, Hassabo, HM, Iwasaki, M, Deaton, FL, Abbruzzese, JL, and Thomas, MB. "Efficacy of bevacizumab plus erlotinib for advanced hepatocellular carcinoma and predictors of outcome: final results of a phase II trial." Oncology 82, no. 2 (January 2012): 67-74.

PMID
22327795
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Zhao, Q, Rashid, A, Gong, Y, Katz, MH, Lee, JE, Wolf, R, Balachandran, A, Varadhachary, GR, Pisters, PW, Wang, H, Gomez, HF, Abbruzzese, JL, Fleming, JB, and Wang, H. "Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with a better prognosis." Annals of diagnostic pathology 16, no. 1 (January 2012): 29-37.

PMID
22050964
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Katz, MHG, Wang, H, Balachandran, A, Bhosale, P, Crane, CH, Wang, X, Pisters, PWT, Lee, JE, Vauthey, J-N, Abdalla, EK, Wolff, R, Abbruzzese, J, Varadhachary, G, Chopin-Laly, X, Charnsangavej, C, and Fleming, JB. "Effect of neoadjuvant chemoradiation and surgical technique on recurrence of localized pancreatic cancer." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract 16, no. 1 (January 2012): 68-78.

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22065318
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Estrella, JS, Rashid, A, Fleming, JB, Katz, MH, Lee, JE, Wolf, RA, Varadhachary, GR, Pisters, PWT, Abdalla, EK, Vauthey, J-N, Wang, H, Gomez, HF, Evans, DB, Abbruzzese, JL, and Wang, H. "Post-therapy pathologic stage and survival in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant chemoradiation." Cancer 118, no. 1 (January 2012): 268-277.

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21735446
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Fogelman, D, Jafari, M, Varadhachary, GR, Xiong, H, Bullock, S, Ozer, H, Lin, E, Morris, J, Cunningham, P, Bennett, B, Abbruzzese, JL, and Wolff, RA. "Bevacizumab plus gemcitabine and oxaliplatin as first-line therapy for metastatic or locally advanced pancreatic cancer: a phase II trial." Cancer chemotherapy and pharmacology 68, no. 6 (December 2011): 1431-1438.

PMID
21479635
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Chang, DZ, Ma, Y, Ji, B, Wang, H, Deng, D, Liu, Y, Abbruzzese, JL, Liu, Y-J, Logsdon, CD, and Hwu, P. "Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma." Clinical cancer research : an official journal of the American Association for Cancer Research 17, no. 22 (November 2011): 7015-7023.

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21976550
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Kaseb, AO, Morris, JS, Hassan, MM, Siddiqui, AM, Lin, E, Xiao, L, Abdalla, EK, Vauthey, J-N, Aloia, TA, Krishnan, S, and Abbruzzese, JL. "Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma." Journal of Clinical Oncology 29, no. 29 (October 2011): 3892-3899.

PMID
21911725
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Carbone, C, Moccia, T, Zhu, C, Paradiso, G, Budillon, A, Chiao, PJ, Abbruzzese, JL, and Melisi, D. "Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype." Clinical cancer research : an official journal of the American Association for Cancer Research 17, no. 17 (September 2011): 5822-5832.

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21737511
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Abbruzzese, JL. "Introducing CCR perspectives in drug approval." Clinical cancer research : an official journal of the American Association for Cancer Research 17, no. 15 (August 2011): 4929-.

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21791634
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Pages