Jatin Roper, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 905 S. Lasalle Street, Gsrb-1, Room 1033, Durham, NC 27710
Phone (919) 660-2923
Email address jatin.roper@duke.edu

My laboratory is interested in understanding the molecular mechanisms of stem cell function in the normal intestine and in colorectal cancer using innovative three-dimensional organoid and in vivo platforms. We demonstrated that high fat diet-induced obesity activates peroxisome proliferator-activated receptor delta (PPARd) signaling in intestinal stem cells and progenitor cells, which increases stem cell regeneration and tumor initiation in the colon. We also pioneered novel orthotopic transplantation and in situ CRISPR/Cas9 gene editing models of colorectal cancer that recapitulate the adenoma-carcinoma-metastasis sequence. Research in the laboratory is focused on three main areas: 1) Immune regulation of the intestinal epithelium and colorectal cancer; 2) The effects of diet-induced obesity on regeneration in the intestine; and 3) analysis of colorectal cancer heterogeneity with single-cell mRNA sequencing and genetically engineered mouse models. The overall goal of this research is to develop new treatment approaches for intestinal diseases such as inflammatory bowel disease and colorectal cancer. I am also a gastroenterologist at Duke University Hospital and the Durham VA Hospital. My clinical interests include colorectal cancer screening and gastrointestinal cancer genetics.

Education and Training

  • Postdoctoral Fellow (mentor: Omer H. Yilmaz, M.D., PhD), Koch Institute for Integrative Cancer Research at MIT, 2014 - 2018
  • Postdoctoral Fellow in Gastroenterology and Hepatology, Tufts University School of Medicine, 2011 - 2014
  • Fellowship in Gastroenterology and Hepatology, Tufts University School of Medicine, 2008 - 2012
  • Residency in Internal Medicine, New York University School of Medicine, 2006 - 2008
  • Michael Saperstein Medical Scholar, New York University School of Medicine, 2005 - 2006
  • Internship in Internal Medicine, New York University School of Medicine, 2004 - 2005
  • M.D., Boston University School of Medicine, 2004

Publications

Han, Huajun, Laurie A. Davidson, Yang-Yi Fan, Jennifer S. Goldsby, Grace Yoon, Un-Ho Jin, Gus A. Wright, et al. “Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.” Embo J, August 10, 2020, e104319. https://doi.org/10.15252/embj.2019104319.

PMID
32915464
Full Text

Cheung, Priscilla, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, et al. “Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.” Cell Stem Cell, July 24, 2020. https://doi.org/10.1016/j.stem.2020.07.003.

PMID
32730753
Full Text

Cheltsov, Anton, Natsuko Nomura, Venkata M. Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov. “Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer.” Sci Rep 10, no. 1 (May 15, 2020): 8096. https://doi.org/10.1038/s41598-020-60784-y.

PMID
32415084
Full Text

Rickelt, Steffen, Charlene Condon, Miyeko Mana, Charlie Whittaker, Christina Pfirschke, Jatin Roper, Deepa T. Patil, et al. “Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.” Clin Cancer Res 26, no. 6 (March 15, 2020): 1277–87. https://doi.org/10.1158/1078-0432.CCR-19-2898.

PMID
31852835
Full Text

Sullivan, Brian, and Jatin Roper. “Single Dose Aspirin before Fecal Immunochemical Testing Does Not Increase Sensitivity for Advanced Colorectal Neoplasia.” Gastroenterology 157, no. 4 (October 2019): 1158–59. https://doi.org/10.1053/j.gastro.2019.08.002.

PMID
31400365
Full Text

Jackstadt, Rene, Sander R. van Hooff, Joshua D. Leach, Xabier Cortes-Lavaud, Jeroen O. Lohuis, Rachel A. Ridgway, Valérie M. Wouters, et al. “Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.” Cancer Cell 36, no. 3 (September 16, 2019): 319-336.e7. https://doi.org/10.1016/j.ccell.2019.08.003.

PMID
31526760
Full Text

Almeqdadi, Mohammad, Miyeko D. Mana, Jatin Roper, and Ömer H. Yilmaz. “Gut organoids: mini-tissues in culture to study intestinal physiology and disease.” Am J Physiol Cell Physiol 317, no. 3 (September 1, 2019): C405–19. https://doi.org/10.1152/ajpcell.00300.2017.

PMID
31216420
Full Text

Serebrennikova, Oksana B., Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce, and Philip N. Tsichlis. “The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.” Proc Natl Acad Sci U S A 116, no. 28 (July 9, 2019): 14039–48. https://doi.org/10.1073/pnas.1901465116.

PMID
31239343
Full Text

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