Jatin Roper, MD

Assistant Professor of Medicine
Assistant Professor in Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 905 S. Lasalle Street, Gsrb-1, Room 1033, Durham, NC 27710
Phone (919) 660-2923
Email address jatin.roper@duke.edu

My laboratory is interested in understanding the molecular mechanisms of stem cell function in the normal intestine and in colorectal cancer using innovative three-dimensional organoid and in vivo platforms. We demonstrated that high fat diet-induced obesity activates peroxisome proliferator-activated receptor delta (PPARd) signaling in intestinal stem cells and progenitor cells, which increases stem cell regeneration and tumor initiation in the colon. We also pioneered novel orthotopic transplantation and in situ CRISPR/Cas9 gene editing models of colorectal cancer that recapitulate the adenoma-carcinoma-metastasis sequence. Research in the laboratory is focused on three main areas: 1) Immune regulation of the intestinal epithelium and colorectal cancer; 2) The effects of diet-induced obesity on regeneration in the intestine; and 3) analysis of colorectal cancer heterogeneity with single-cell mRNA sequencing and genetically engineered mouse models. The overall goal of this research is to develop new treatment approaches for intestinal diseases such as inflammatory bowel disease and colorectal cancer. I am also a gastroenterologist at Duke University Hospital and the Durham VA Hospital. My clinical interests include colorectal cancer screening and gastrointestinal cancer genetics.

Education and Training

  • Postdoctoral Fellow (mentor: Omer H. Yilmaz, M.D., PhD), Koch Institute for Integrative Cancer Research at MIT, 2014 - 2018
  • Postdoctoral Fellow in Gastroenterology and Hepatology, Tufts University School of Medicine, 2011 - 2014
  • Fellowship in Gastroenterology and Hepatology, Tufts University School of Medicine, 2008 - 2012
  • Residency in Internal Medicine, New York University School of Medicine, 2006 - 2008
  • Michael Saperstein Medical Scholar, New York University School of Medicine, 2005 - 2006
  • Internship in Internal Medicine, New York University School of Medicine, 2004 - 2005
  • M.D., Boston University School of Medicine, 2004

Publications

Lee, Tzu-Hao, Jatin Roper, and Lindsay King. “Mirror, Mirror, on the Wall, Who Is the Fittest of Them All? A Novel Prediction Model for Postoperative Hepatic Decompensation in Patients With Cirrhosis.” Gastroenterology 162, no. 4 (April 2022): 1352–53. https://doi.org/10.1053/j.gastro.2021.10.024.

PMID
34688708
Full Text

Sullivan, Brian A., Michael Noujaim, and Jatin Roper. “Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer.” Gastrointest Endosc Clin N Am 32, no. 2 (April 2022): 177–94. https://doi.org/10.1016/j.giec.2021.12.001.

PMID
35361330
Full Text

Wu, Xian, Per M. Ueland, Jatin Roper, Gar Yee Koh, Xu Liang, Jimmy W. Crott, Ömer H. Yilmaz, Roderick T. Bronson, and Joel B. Mason. “Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice.” J Nutr 151, no. 12 (December 3, 2021): 3678–88. https://doi.org/10.1093/jn/nxab320.

PMID
34590119
Full Text

Beyaz, Semir, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, et al. “Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.” Cell Stem Cell 28, no. 11 (November 4, 2021): 1922-1935.e5. https://doi.org/10.1016/j.stem.2021.08.007.

PMID
34529935
Full Text

Glenny, Elaine M., Laura W. Bowers, Diana Li, Jatin Roper, and Stephen D. Hursting. “Links between obesity and secreted frizzled-related protein 4 (Sfrp4) in a murine model of colon cancer.” In Cancer Research, Vol. 81, 2021.

Scholars@Duke

Sheahan, Breanna J., Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, and Christopher M. Dekaney. “Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells.” Cell Mol Gastroenterol Hepatol 12, no. 1 (2021): 119–40. https://doi.org/10.1016/j.jcmgh.2021.01.015.

PMID
33571711
Full Text

Kendall, Wesley Y., Julianna Bordas, Evan T. Jelly, Babak Mirminachi, Abel Joseph, Jatin Roper, and Adam Wax. “Spectroscopic optical coherence tomography for early detection of colorectal cancer in a mouse model.” In Bio Optics: Design and Application, DF1A-4, 2021.

Scholars@Duke

Cheung, Priscilla, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, et al. “Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.” Cell Stem Cell 27, no. 4 (October 1, 2020): 590-604.e9. https://doi.org/10.1016/j.stem.2020.07.003.

PMID
32730753
Full Text

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