Jeffrey Crawford, MD

Professor of Medicine
George Barth Geller Professor
Associate Director of Clinical Research, Comprehensive Cancer Center
Member of the Duke Cancer Institute
Campus mail 443 Seeley G. Mudd Bldg, Durham, NC 27710
Phone (919) 681-9509
Email address crawf006@mc.duke.edu

1. Lung cancer/new treatment approaches.
2. Clinical trials of hematopoietic growth factors, biological agents and targeted drug development.
3. Cancer in the elderly and supportive care

Accomplishments

1. Lead Investigator of the U. S. multicenter, randomized trial of Filgrastim (G-CSF, Neupogen) to reduce the morbidity of chemotherapy-related neutropenia, leading to FDA approval 2/91.
2. Lead Investigator of the U. S. multicenter, randomized trial of Vinorelbine (Navelbine) in treatment of patients with advanced non small cell carcinoma of lung (NSCLC), leading to FDA approval 12/94.
3. Principal Investigator in initial phase I clinical trials of stem cell factor (SCF), megakaryocyte growth and development factor (MGDF), pegylated granulocyte-colony-stimulating factor and other novel hematopoietic growth factors.

In Their Words

Education and Training

  • M.D., Ohio State University, 1974

Publications

Dale, DC, Crawford, J, Klippel, Z, Reiner, M, Osslund, T, Fan, E, Morrow, PK, Allcott, K, and Lyman, GH. "A systematic literature review of the efficacy, effectiveness, and safety of filgrastim." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26, no. 1 (January 2018): 7-20. (Review)

PMID
28939926
Full Text

Crawford, J, Becker, PS, Armitage, JO, Blayney, DW, Chavez, J, Curtin, P, Dinner, S, Fynan, T, Gojo, I, Griffiths, EA, Hough, S, Kloth, DD, Kuter, DJ, Lyman, GH, Mably, M, Mukherjee, S, Patel, S, Perez, LE, Poust, A, Rampal, R, Roy, V, Rugo, HS, Saad, AA, Schwartzberg, LS, Shayani, S, Talbott, M, Vadhan-Raj, S, Vasu, S, Wadleigh, M, Westervelt, P, Burns, JL, and Pluchino, L. "Myeloid growth factors, version 2.2017." JNCCN Journal of the National Comprehensive Cancer Network 15, no. 12 (December 1, 2017): 1520-1541. (Review)

Full Text

Yi, JS, Ready, N, Healy, P, Dumbauld, C, Osborne, R, Berry, M, Shoemaker, D, Clarke, J, Crawford, J, Tong, B, Harpole, D, D'Amico, TA, McSherry, F, Dunphy, F, McCall, SJ, Christensen, JD, Wang, X, and Weinhold, KJ. "Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab." Clinical cancer research : an official journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7474-7482.

PMID
28951518
Full Text

Cupp, J, Culakova, E, Poniewierski, MS, Dale, DC, Lyman, GH, and Crawford, J. "Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia." October 28, 2017.

PMID
29233611
Full Text

Le-Rademacher, JG, Crawford, J, Evans, WJ, and Jatoi, A. "Overcoming obstacles in the design of cancer anorexia/weight loss trials." Critical reviews in oncology/hematology 117 (September 2017): 30-37. (Review)

PMID
28807233
Full Text

Tandberg, DJ, Kelsey, CR, D'Amico, TA, Crawford, J, Chino, JP, Tong, BC, Ready, NE, and Wright, A. "Patterns of Failure After Surgery for Non-Small-cell Lung Cancer Invading the Chest Wall." Clinical lung cancer 18, no. 4 (July 2017): e259-e265.

PMID
27965012
Full Text

Winckworth-Prejsnar, K, Nardi, EA, Lentz, LK, Crawford, JA, Fitzgerald, CL, and Carlson, RW. "Developments in Molecular Testing and Biosimilars." Journal of the National Comprehensive Cancer Network : JNCCN 15, no. 6 (June 2017): 772-782.

PMID
28596257
Full Text

Baggstrom, MQ, Socinski, MA, Wang, XF, Gu, L, Stinchcombe, TE, Edelman, MJ, Baker, S, Feliciano, J, Novotny, P, Hahn, O, Crawford, JA, and Vokes, EE. "Maintenance Sunitinib following Initial Platinum-Based Combination Chemotherapy in Advanced-Stage IIIB/IV Non–Small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study—CALGB 30607 (Alliance)." Journal of Thoracic Oncology 12, no. 5 (May 2017): 843-849.

Full Text

Riedel, RF, Meadows, KL, Lee, PH, Morse, MA, Uronis, HE, Blobe, GC, George, DJ, Crawford, J, Niedzwiecki, D, Rushing, CN, Arrowood, CC, and Hurwitz, HI. "Phase I study of pazopanib plus TH-302 in advanced solid tumors." Cancer chemotherapy and pharmacology 79, no. 3 (March 2017): 611-619.

PMID
28238078
Full Text

Wang, X, Wang, X, Hodgson, L, George, SL, Sargent, DJ, Foster, NR, Ganti, AK, Stinchcombe, TE, Crawford, J, Kratzke, R, Adjei, AA, Kindler, HL, Vokes, EE, and Pang, H. "Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials." The oncologist 22, no. 2 (February 10, 2017): 189-198.

PMID
28188257
Full Text

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