Jeffrey Crawford, MD

Professor of Medicine
George Barth Geller Professor
Associate Director of Clinical Research, Comprehensive Cancer Center
Member of the Duke Cancer Institute
Campus mail 443 Seeley G. Mudd Bldg, Durham, NC 27710
Phone (919) 681-9509
Email address crawf006@mc.duke.edu

1. Lung cancer/new treatment approaches.
2. Clinical trials of hematopoietic growth factors, biological agents and targeted drug development.
3. Cancer in the elderly and supportive care

Accomplishments

1. Lead Investigator of the U. S. multicenter, randomized trial of Filgrastim (G-CSF, Neupogen) to reduce the morbidity of chemotherapy-related neutropenia, leading to FDA approval 2/91.
2. Lead Investigator of the U. S. multicenter, randomized trial of Vinorelbine (Navelbine) in treatment of patients with advanced non small cell carcinoma of lung (NSCLC), leading to FDA approval 12/94.
3. Principal Investigator in initial phase I clinical trials of stem cell factor (SCF), megakaryocyte growth and development factor (MGDF), pegylated granulocyte-colony-stimulating factor and other novel hematopoietic growth factors.

In Their Words

Education and Training

  • M.D., Ohio State University, 1974

Publications

Dale, DC, Crawford, J, Klippel, Z, Reiner, M, Osslund, T, Fan, E, Morrow, PK, Allcott, K, and Lyman, GH. "A systematic literature review of the efficacy, effectiveness, and safety of filgrastim. (Accepted)" Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26, no. 1 (January 2018): 7-20. (Review)

PMID
28939926
Full Text

Tandberg, DJ, Kelsey, CR, D'Amico, TA, Crawford, J, Chino, JP, Tong, BC, Ready, NE, and Wright, A. "Patterns of Failure After Surgery for Non-Small-cell Lung Cancer Invading the Chest Wall." Clinical lung cancer 18, no. 4 (July 2017): e259-e265.

PMID
27965012
Full Text

Riedel, RF, Meadows, KL, Lee, PH, Morse, MA, Uronis, HE, Blobe, GC, George, DJ, Crawford, J, Niedzwiecki, D, Rushing, CN, Arrowood, CC, and Hurwitz, HI. "Phase I study of pazopanib plus TH-302 in advanced solid tumors." Cancer chemotherapy and pharmacology 79, no. 3 (March 2017): 611-619.

PMID
28238078
Full Text

Wang, X, Wang, X, Hodgson, L, George, SL, Sargent, DJ, Foster, NR, Ganti, AK, Stinchcombe, TE, Crawford, J, Kratzke, R, Adjei, AA, Kindler, HL, Vokes, EE, and Pang, H. "Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials." The oncologist 22, no. 2 (February 10, 2017): 189-198.

PMID
28188257
Full Text

Kelley, MJ, Jha, G, Shoemaker, D, Herndon, JE, Gu, L, Barry, WT, Crawford, J, and Ready, N. "Phase II Study of Dasatinib in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer." Cancer investigation 35, no. 1 (January 2017): 32-35.

PMID
27911119
Full Text

Boyer, MJ, Gu, L, Wang, X, Kelsey, CR, Yoo, DS, Onaitis, MW, Dunphy, FR, Crawford, J, Ready, NE, and Salama, JK. "Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer." Lung cancer (Amsterdam, Netherlands) 98 (August 2016): 76-78.

PMID
27393510
Full Text

Crawford, J, Prado, CMM, Johnston, MA, Gralla, RJ, Taylor, RP, Hancock, ML, and Dalton, JT. "Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)." Current oncology reports 18, no. 6 (June 2016): 37-. (Review)

PMID
27138015
Full Text

Raftopoulos, H, Laadem, A, Hesketh, PJ, Goldschmidt, J, Gabrail, N, Osborne, C, Ali, M, Sherman, ML, Wang, D, Glaspy, JA, Puccio-Pick, M, Zou, J, and Crawford, J. "Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 24, no. 4 (April 2016): 1517-1525.

PMID
26370220
Full Text

Salama, JK, Gu, L, Wang, X, Pang, HH, Bogart, JA, Crawford, J, Schild, SE, Vokes, EE, and Ready, NE. "Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 11, no. 3 (March 2016): 361-369.

PMID
26723241
Full Text

Crawford, J, Wheatley-Price, P, and Feliciano, JL. "Treatment of Lung Cancer in Medically Compromised Patients." American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting 35 (January 2016): e484-e491.

PMID
27249757
Full Text

Pages