Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Professor in the Department of Surgery
Campus mail 201 Msrb1 Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Ferrante, Sarah, Tillie-Louise Hackett, John F. Engelhardt, Jennifer L. Ingram, Susan Reynolds, Yulong Zhang, Claire E. Hoptay, et al. “IN VIVO EVIDENCE IN A XENOGRAFT MODEL FOR ASTHMATIC EPITHELIUM DRIVING AIRWAY REMODELING.” Journal of Investigative Medicine 63, no. 3 (March 1, 2015): 569–569.

Scholars@Duke

Ingram, Jennifer L., Robert W. Sigmon, Barbara Theriot, Michael Ghio, Akhil Hegde, Dave Francisco, Julia K. L. Walker, and Monica Kraft. “Leptin Modulates Airway Remodeling Processes and Responses to Interleukin-13 in Lung Fibroblasts in a Murine Model of Chronic Allergic Airways Disease.” In Journal of Allergy and Clinical Immunology, 135:AB382–AB382. Elsevier BV, 2015. https://doi.org/10.1016/j.jaci.2014.12.1876.

Full Text

Ledford, J. G., N. Lugogo, N. Agada, J. Weiss, D. C. Francisco, J. L. Ingram, M. E. Sunday, L. G. Que, and M. Kraft. “Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Ingram, J. L., J. Weiss, M. Ghio, D. C. Francisco, R. W. Sigmon, N. Lugogo, and M. Kraft. “Leptin Augments Interleukin-13-Induced Eotaxin-1 And Eotaxin-3 Production By Airway Fibroblasts In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Ferrante, S. C., J. L. Ingram, E. Nadler, M. Hubal, J. Seo, M. Giri, D. Jung, D. K. Pillai, J. M. Wang, and R. J. Freishtat. “Asthmatic Airway Fibroblasts: Tgf beta Receptor Signaling Is Up-Regulated After Obese Visceral Adipose Exosome Exposure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Ferrante, S. C., T. -. L. Hackett, J. F. Engelhardt, J. L. Ingram, S. D. Reynolds, Y. Zhang, C. E. Hoptay, et al. “In Vivo Evidence In A Xenograft Model For Asthmatic Epithelium Driving Airway Remodeling.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Firszt, Rafael, Dave Francisco, Tony D. Church, Joseph M. Thomas, Jennifer L. Ingram, and Monica Kraft. “Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma.” Eur Respir J 43, no. 2 (February 2014): 464–73. https://doi.org/10.1183/09031936.00068712.

PMID
23682108
Full Text

Ingram, J. L., B. Theriot, A. Hegde, J. Thomas, J. K. Walker, P. W. Noble, and M. Kraft. “Over-Expression Of Hyaluronan Synthase 2 (has2) In Contractile Cells Reduces Airways Hyperresponsiveness In A Mouse Model Of Chronic Allergic Airways Disease.” American Journal of Respiratory and Critical Care Medicine 189 (January 1, 2014).

Scholars@Duke

Ingram, J. L., B. Theriot, D. Francisco, T. Church, D. Slade, D. Beaver, N. Lugogo, J. Walker, and M. Kraft. “Obesity Influences Airway Fibroblast Invasiveness And Extracellular Matrix Expression In Asthma: Implications For The Pathobiology Of Airway Remodeling In Distinct Asthma Endotypes.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.

Scholars@Duke

Ingram, J. L., D. Slade, D. Francisco, T. Church, D. Beaver, and M. Kraft. “Matrix Metalloproteinase 1 (mmp-1) Mediates Interleukin-13 (il-13)-Induced Suppression Of Elastin Expression In Airway Fibroblasts In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.

Scholars@Duke

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