John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Leiria, TLL, Lopes, RD, Williams, JB, Katz, JN, Kalil, RAK, and Alexander, JH. "Antithrombotic therapies in patients with prosthetic heart valves: guidelines translated for the clinician." Journal of thrombosis and thrombolysis 31, no. 4 (May 2011): 514-522. (Review)

PMID
21327503
Full Text

Domanski, MJ, Mahaffey, K, Hasselblad, V, Brener, SJ, Smith, PK, Hillis, G, Engoren, M, Alexander, JH, Levy, JH, Chaitman, BR, Broderick, S, Mack, MJ, Pieper, KS, and Farkouh, ME. "Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery." Jama 305, no. 6 (February 2011): 585-591.

PMID
21304084
Full Text

Povsic, TJ, Cohen, MG, Mehran, R, Buller, CE, Bode, C, Cornel, JH, Kasprzak, JD, Montalescot, G, Joseph, D, Wargin, WA, Rusconi, CP, Zelenkofske, SL, Becker, RC, and Alexander, JH. "A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial." Am Heart J 161, no. 2 (February 2011): 261-268.e1-2-.

PMID
21315207
Full Text

Povsic, TJ, Cohen, MG, Chan, MY, Zelenkofske, SL, Wargin, WA, Harrington, RA, Alexander, JH, Rusconi, CP, and Becker, RC. "Dose Selection for a Direct and Selective Factor IXa Inhibitor and its Complementary Reversal Agent: Translating Pharmacokinetic and Pharmacodynamic Properties of the REG1 System to Clinical Trial Design." Journal of Thrombosis and Thrombolysis (2011): 1-11.

Full Text

Alexander, J. "SY06-5 Apixaban for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation: Primary Results of the ARISTOTLE Trial." Journal of Arrhythmia 27 (January 1, 2011).

Full Text

Mehta, RH, Stebbins, A, Lopes, RD, Rao, SV, Bates, ER, Pieper, KS, Armstrong, PW, Van de Werf, F, White, HD, Califf, RM, Alexander, JH, and Granger, CB. "Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy." The American Journal of Medicine 124, no. 1 (January 2011): 48-57.

PMID
21187185
Full Text

Stashenko, G, Lopes, RD, Garcia, D, Alexander, JH, and Tapson, VF. "Prophylaxis for venous thromboembolism: guidelines translated for the clinician." J Thromb Thrombolysis 31, no. 1 (January 2011): 122-132. (Review)

PMID
20936495
Full Text

Piccini, JP, Schulte, PJ, Pieper, KS, Mehta, RH, White, HD, Van de Werf, F, Ardissino, D, Califf, RM, Granger, CB, Ohman, EM, and Alexander, JH. "Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction." Critical Care Medicine 39, no. 1 (January 2011): 78-83.

PMID
20959785
Full Text

Alexander, JH, Lopes, RD, and Wallentin, L. "The authors reply." New England Journal of Medicine 365, no. 19 (2011): 1844-1845.

Full Text

Becker, RC, Alexander, JH, Newby, LK, Yang, H, Barrett, Y, Mohan, P, Wang, J, Harrington, RA, and Wallentin, LC. "Effect of apixaban, an oral and direct factor Xa inhibitor, on coagulation activity biomarkers following acute coronary syndrome." Thromb Haemost 104, no. 5 (November 2010): 976-983.

PMID
20806117
Full Text

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