John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Khan, R, Lopes, RD, Neely, ML, Stevens, SR, Harrington, RA, Diaz, R, Cools, F, Jansky, P, Montalescot, G, Atar, D, Lopez-Sendon, J, Flather, M, Liaw, D, Wallentin, L, Alexander, JH, and Goodman, SG. "Characterising and predicting bleeding in high-risk patients with an acute coronary syndrome." Heart (2015).

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Cornel, JH, Lopes, RD, James, S, Stevens, SR, Neely, ML, Liaw, D, Miller, J, Mohan, P, Amerena, J, Raev, D, Huo, Y, Urina-Triana, M, Gallegos Cazorla, A, Vinereanu, D, Fridrich, V, Harrington, RA, Wallentin, L, and Alexander, JH. "Anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes: Insights from the APixaban for PRevention of Acute ISchemic Events 2 trial." American Heart Journal 169, no. 4 (January 1, 2015): 531-538.

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Garcia, D, Alexander, JH, Wallentin, L, Wojdyla, DM, Thomas, L, Hanna, M, Al-Khatib, SM, Dorian, P, Ansell, J, Commerford, P, Flaker, G, Lanas, F, Vinereanu, D, Xavier, D, Hylek, EM, Held, C, Verheugt, FWA, Granger, CB, and Lopes, RD. "Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures." Blood 124, no. 25 (December 2014): 3692-3698.

PMID
25320240
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Smith, PK, Puskas, JD, Ascheim, DD, Voisine, P, Gelijns, AC, Moskowitz, AJ, Hung, JW, Parides, MK, Ailawadi, G, Perrault, LP, Acker, MA, Argenziano, M, Thourani, V, Gammie, JS, Miller, MA, Pagé, P, Overbey, JR, Bagiella, E, Dagenais, F, Blackstone, EH, Kron, IL, Goldstein, DJ, Rose, EA, Moquete, EG, Jeffries, N, Gardner, TJ, O'Gara, PT, Alexander, JH, Michler, RE, and Cardiothoracic Surgical Trials Network Investigators, . "Surgical treatment of moderate ischemic mitral regurgitation." The New England journal of medicine 371, no. 23 (December 2014): 2178-2188.

PMID
25405390
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Wallentin, L, Hijazi, Z, Andersson, U, Alexander, JH, De Caterina, R, Hanna, M, Horowitz, JD, Hylek, EM, Lopes, RD, Asberg, S, Granger, CB, Siegbahn, A, and ARISTOTLE Investigators, . "Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial." Circulation 130, no. 21 (November 2014): 1847-1858.

PMID
25294786
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Harskamp, RE, Schulte, PJ, Alexander, JH, and Lopes, RD. "Reply: To PMID 24360877." The Annals of thoracic surgery 98, no. 5 (November 2014): 1890-. (Letter)

PMID
25441825
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Yiyit, N. "Definition of the Inclusion Criteria of Poland's Syndrome." The Annals of Thoracic Surgery 98, no. 5 (November 2014): 1886-1886.

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Vavalle, JP, Rusconi, CP, Zelenkofske, S, Wargin, WA, Ortel, TL, Alexander, JH, Povsic, TJ, and Becker, RC. "The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study." Journal of thrombosis and thrombolysis 38, no. 3 (October 2014): 275-284.

PMID
24880800
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Harskamp, RE, Walker, PF, Alexander, JH, Xian, Y, Liberman, HA, de Winter, RJ, Vassiliades, TA, Peterson, ED, Puskas, JD, and Halkos, ME. "Clinical outcomes of hybrid coronary revascularization versus coronary artery bypass surgery in patients with diabetes mellitus." American heart journal 168, no. 4 (October 2014): 471-478.

PMID
25262256
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Hess, CN, Lopes, RD, Gibson, CM, Hager, R, Wojdyla, DM, Englum, BR, Mack, MJ, Califf, RM, Kouchoukos, NT, Peterson, ED, and Alexander, JH. "Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV." Circulation 130, no. 17 (October 2014): 1445-1451.

PMID
25261549
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