Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Piantadosi, Claude A., Raquel R. Bartz, Martha S. Carraway, Andrew J. Ghio, Timothy J. McMahon, David M. Murdoch, Victor L. Roggli, et al. “The opprobrium of Big Tobacco..” Am J Respir Crit Care Med 185, no. 9 (May 1, 2012). https://doi.org/10.1164/ajrccm.185.9.1030.

PMID
22550218
Full Text

MacGarvey, Nancy Chou, Hagir B. Suliman, Raquel R. Bartz, Ping Fu, Crystal M. Withers, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis..” Am J Respir Crit Care Med 185, no. 8 (April 15, 2012): 851–61. https://doi.org/10.1164/rccm.201106-1152OC.

PMID
22312014
Full Text

Piantadosi, Claude A., Crystal M. Withers, Raquel R. Bartz, Nancy Chou MacGarvey, Ping Fu, Timothy E. Sweeney, Karen E. Welty-Wolf, and Hagir B. Suliman. “Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression..” J Biol Chem 286, no. 18 (May 6, 2011): 16374–85. https://doi.org/10.1074/jbc.M110.207738.

PMID
21454555
Full Text

Piantadosi, Claude A., Crystal M. Withers, Raquel R. Bartz, Nancy C. MacGarvey, Timothy E. Sweeney, Karen E. Welty-Wolf, and Hagir B. Suliman. “Redox Activation of Mitochondrial Biogenesis by Heme Oxygenase-1 Exerts Counter-regulatory Control over NF-kB-dependent Cytokine Production.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.

Scholars@Duke

Bartz, Raquel R., Hagir B. Suliman, Ping Fu, Karen Welty-Wolf, Martha Sue Carraway, Nancy Chou MacGarvey, Crystal M. Withers, Timothy E. Sweeney, and Claude A. Piantadosi. “Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice..” Am J Respir Crit Care Med 183, no. 2 (January 15, 2011): 226–33. https://doi.org/10.1164/rccm.200911-1709OC.

PMID
20732986
Full Text

Sweeney, Timothy E., Hagir B. Suliman, John W. Hollingsworth, Karen E. Welty-Wolf, and Claude A. Piantadosi. “A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis..” Plos One 6, no. 9 (2011). https://doi.org/10.1371/journal.pone.0025249.

PMID
21966468
Full Text

Suliman, Hagir B., Abdelwahid Babiker, Crystal M. Withers, Timothy E. Sweeney, Martha S. Carraway, Lynn G. Tatro, Raquel R. Bartz, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice..” Free Radic Biol Med 48, no. 5 (March 1, 2010): 736–46. https://doi.org/10.1016/j.freeradbiomed.2009.12.019.

PMID
20043987
Full Text

Reynolds, Crystal M., Hagir B. Suliman, John W. Hollingsworth, Karen E. Welty-Wolf, Martha Sue Carraway, and Claude A. Piantadosi. “Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia..” Free Radic Biol Med 46, no. 5 (March 1, 2009): 564–72. https://doi.org/10.1016/j.freeradbiomed.2008.11.007.

PMID
19073249
Full Text

Reddy, Anita J., Christopher W. Woods, and Karen E. Welty-Wolf. “Eastern equine encephalitis leading to multi-organ failure and sepsis..” J Clin Virol 42, no. 4 (August 2008): 418–21. https://doi.org/10.1016/j.jcv.2008.03.008.

PMID
18456547
Full Text

Carraway, Martha S., Hagir B. Suliman, Corrine Kliment, Karen E. Welty-Wolf, Tim D. Oury, and Claude A. Piantadosi. “Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis..” Antioxid Redox Signal 10, no. 2 (February 2008): 269–75. https://doi.org/10.1089/ars.2007.1910.

PMID
17999632
Full Text

Pages