Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.
Education and Training
- Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
- Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
- Medical Resident, Medicine, Duke University, 1986 - 1989
- M.D., Duke University, 1986