Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury..” Seminars in Hematology 38, no. 4 Suppl 12 (October 2001): 35–38. https://doi.org/10.1053/shem.2001.29505.

PMID
11735108
Full Text

Welty-Wolf, Karen E., Martha S. Carraway, Steve Idell, Thomas L. Ortel, Mirella Ezban, and Claude A. Piantadosi. “Tissue factor in experimental acute lung injury.” In Seminars in Hematology, 38:35–38. Elsevier BV, 2001. https://doi.org/10.1053/shem.2001.29505.

Full Text

Auten, R. L., S. N. Mason, D. T. Tanaka, K. Welty-Wolf, and M. H. Whorton. “Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.” American Journal of Physiology  Lung Cellular and Molecular Physiology 281, no. 2 25-2 (August 29, 2001).

Scholars@Duke

Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis..” American Journal of Respiratory and Critical Care Medicine 163, no. 3 Pt 1 (March 2001): 665–73. https://doi.org/10.1164/ajrccm.163.3.2004191.

PMID
11254521
Full Text

Welty-Wolf, K. E., M. S. Carraway, Y. C. T. Huang, S. G. Simonson, S. P. Kantrow, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis.” American Journal of Respiratory and Critical Care Medicine 163, no. 3 (March 2001): 665–73. https://doi.org/10.1164/ajrccm.163.3.2004191.

Full Text

Welty-Wolf, K. E., M. S. Carraway, Y. C. T. Huang, S. G. Simonson, S. P. Kantrow, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis.” American Journal of Respiratory and Critical Care Medicine 163, no. 3 I (January 1, 2001): 665–73. https://doi.org/10.1164/ajrccm.163.3.2004191.

Full Text

Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.” Seminars in Hematology 38, no. 4 SUPPL. 12 (January 1, 2001): 35–38.

Scholars@Duke

Welty-Wolf, K. E., M. S. Carraway, A. Ghio, S. P. Kantrow, Y. C. Huang, and C. A. Piantadosi. “Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy..” Shock (Augusta, Ga.) 13, no. 5 (May 2000): 404–9.

PMID
10807017
Scholars@Duke

Welty-Wolf, K. E., and C. A. Piantadosi. “LPS amplifies or attenuates endotoxin-induced acute lung injury in mice depending on route of priming exposure..” American Journal of Respiratory and Critical Care Medicine 159, no. 3 (March 1, 1999): A599–A599.

Scholars@Duke

Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. T. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” American Journal of Respiratory and Critical Care Medicine 157, no. 3 PART I (December 1, 1998): 938–49.

Scholars@Duke

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