Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis..” Am J Respir Crit Care Med 163, no. 3 Pt 1 (March 2001): 665–73. https://doi.org/10.1164/ajrccm.163.3.2004191.

PMID
11254521
Full Text

Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.” Seminars in Hematology 38, no. 4 SUPPL. 12 (January 1, 2001): 35–38.

Scholars@Duke

Welty-Wolf, K. E., M. S. Carraway, A. Ghio, S. P. Kantrow, Y. C. Huang, and C. A. Piantadosi. “Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy..” Shock 13, no. 5 (May 2000): 404–9. https://doi.org/10.1097/00024382-200005000-00010.

PMID
10807017
Full Text

Welty-Wolf, K. E., and C. A. Piantadosi. “LPS amplifies or attenuates endotoxin-induced acute lung injury in mice depending on route of priming exposure..” American Journal of Respiratory and Critical Care Medicine 159, no. 3 (March 1, 1999): A599–A599.

Scholars@Duke

Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. T. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” American Journal of Respiratory and Critical Care Medicine 157, no. 3 PART I (December 1, 1998): 938–49.

Scholars@Duke

Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, and C. A. Piantadosi. “Bacterial priming increases lung injury in gram-negative sepsis..” Am J Respir Crit Care Med 158, no. 2 (August 1998): 610–19. https://doi.org/10.1164/ajrccm.158.2.9704064.

PMID
9700142
Full Text

Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons..” Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.

PMID
9517615
Full Text

Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, S. P. Kantrow, M. S. Carraway, L. Y. Chang, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis..” J Appl Physiol (1985) 83, no. 2 (August 1997): 559–68. https://doi.org/10.1152/jappl.1997.83.2.559.

PMID
9262453
Full Text

Simonson, S. G., K. E. Welty-Wolf, Y. C. Huang, D. E. Taylor, S. P. Kantrow, M. S. Carraway, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry..” J Appl Physiol (1985) 83, no. 2 (August 1997): 550–58. https://doi.org/10.1152/jappl.1997.83.2.550.

PMID
9262452
Full Text

Simonson, S. G., Y. C. Huang, P. J. Fracica, K. E. Welty-Wolf, R. E. Moon, S. L. Young, and C. A. Piantadosi. “Changes in the lung after prolonged positive pressure ventilation in normal baboons..” J Crit Care 12, no. 2 (June 1997): 72–82.

PMID
9165415
Scholars@Duke

Pages