Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris St, Durham, NC 27701
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Lopes, Renato D., Karen P. Alexander, Judith S. Hochman, and David J. Maron. “Response by Lopes et al to Letter Regarding Article, "Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial".” Circulation 143, no. 20 (May 18, 2021): e961–62. https://doi.org/10.1161/CIRCULATIONAHA.121.053672.

PMID
33999666
Full Text

White, Harvey D., Sean M. O’Brien, Karen P. Alexander, William E. Boden, Sripal Bangalore, Jianghao Li, Cholenahally N. Manjunath, et al. “Comparison of Days Alive Out of Hospital With Initial Invasive vs Conservative Management: A Prespecified Analysis of the ISCHEMIA Trial.” Jama Cardiol, May 3, 2021. https://doi.org/10.1001/jamacardio.2021.1651.

PMID
33938917
Full Text

Chaitman, Bernard R., Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, et al. “Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.” Circulation 143, no. 8 (February 23, 2021): 790–804. https://doi.org/10.1161/CIRCULATIONAHA.120.047987.

PMID
33267610
Full Text

Lowenstern, Angela, Karen P. Alexander, and Pamela S. Douglas. “Should We Simplify Computed Tomography Angiography Reporting as Black or White vs Describing All Shades of Gray?-Reply.” Jama Cardiol 5, no. 12 (December 1, 2020): 1450–51. https://doi.org/10.1001/jamacardio.2020.3733.

PMID
32902566
Full Text

Krishnaswami, Ashok, Craig Beavers, Michael P. Dorsch, John A. Dodson, Ruth Masterson Creber, Spyros Kitsiou, Parag Goyal, et al. “Gerotechnology for Older Adults With Cardiovascular Diseases: JACC State-of-the-Art Review.” J Am Coll Cardiol 76, no. 22 (December 1, 2020): 2650–70. https://doi.org/10.1016/j.jacc.2020.09.606.

PMID
33243384
Full Text

Dalgaard, Frederik, Haolin Xu, Roland A. Matsouaka, Andrea M. Russo, Anne B. Curtis, Peter Vibe Rasmussen, Martin H. Ruwald, et al. “Management of Atrial Fibrillation in Older Patients by Morbidity Burden: Insights From Get With The Guidelines-Atrial Fibrillation.” J Am Heart Assoc 9, no. 23 (December 2020): e017024. https://doi.org/10.1161/JAHA.120.017024.

PMID
33241750
Full Text

Sidhu, Mandeep S., Karen P. Alexander, Zhen Huang, Sean M. O’Brien, Bernard R. Chaitman, Gregg W. Stone, Jonathan D. Newman, et al. “Causes of Cardiovascular and Non-cardiovascular Mortality in the Ischemia Trial.” In Circulation, Vol. 142, 2020.

Scholars@Duke

Lopes, Renato D., Karen P. Alexander, Susanna R. Stevens, Harmony R. Reynolds, Gregg W. Stone, Ileana L. Piña, Frank W. Rockhold, et al. “Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial.” Circulation 142, no. 18 (November 3, 2020): 1725–35. https://doi.org/10.1161/CIRCULATIONAHA.120.050304.

PMID
32862662
Full Text

Greenland, Philip, Erin D. Michos, Nicole Redmond, Lawrence J. Fine, Karen P. Alexander, Walter T. Ambrosius, Kirsten Bibbins-Domingo, et al. “Primary Prevention Trial Designs Using Coronary Imaging: A National Heart, Lung, and Blood Institute Workshop.” Jacc Cardiovasc Imaging, September 11, 2020. https://doi.org/10.1016/j.jcmg.2020.06.042.

PMID
32950442
Full Text

Pages