Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Goyal, Parag, Eiran Z. Gorodeski, Kelsey M. Flint, Deena S. Goldwater, John A. Dodson, Jonathan Afilalo, Mathew S. Maurer, Michael W. Rich, Karen P. Alexander, and Scott L. Hummel. “Perspectives on Implementing a Multidomain Approach to Caring for Older Adults With Heart Failure..” J Am Geriatr Soc 67, no. 12 (December 2019): 2593–99. https://doi.org/10.1111/jgs.16183.

PMID
31625160
Full Text

Lowenstern, Angela, Karen P. Alexander, C Larry Hill, Brooke Alhanti, Patricia A. Pellikka, Michael G. Nanna, Rajendra H. Mehta, et al. “Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights From the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial..” Jama Cardiol, November 18, 2019. https://doi.org/10.1001/jamacardio.2019.4973.

PMID
31738382
Full Text

Newman, Jonathan D., Karen P. Alexander, Xiangqiong Gu, Sean M. O’Brien, William E. Boden, Sajeev C. Govindan, Roxy Senior, et al. “Baseline Predictors of Low-Density Lipoprotein Cholesterol and Systolic Blood Pressure Goal Attainment After 1 Year in the ISCHEMIA Trial..” Circ Cardiovasc Qual Outcomes 12, no. 11 (November 2019). https://doi.org/10.1161/CIRCOUTCOMES.119.006002.

PMID
31718297
Full Text

Nanna, Michael G., Eric D. Peterson, Angie Wu, Tina Harding, Anthony N. Galanos, Lisa Wruck, and Karen P. Alexander. “Age, knowledge, preferences, and risk tolerance for invasive cardiac care..” Am Heart J 219 (October 23, 2019): 99–108. https://doi.org/10.1016/j.ahj.2019.09.008.

PMID
31733450
Full Text

Wenger, Nanette K., and Karen P. Alexander. “Not your grandparents' cardiac care: The future of geriatric cardiology..” Clin Cardiol, October 3, 2019. https://doi.org/10.1002/clc.23270.

PMID
31580479
Full Text

Nanna, Michael G., Alexandra M. Hajduk, Harlan M. Krumholz, Terrence E. Murphy, Rachel P. Dreyer, Karen P. Alexander, Mary Geda, et al. “Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction: The SILVER-AMI Study..” Circ Cardiovasc Qual Outcomes 12, no. 10 (October 2019). https://doi.org/10.1161/CIRCOUTCOMES.119.005691.

PMID
31607145
Full Text

Bagai, Akshay, Anita Y. Chen, Jacob A. Udell, John A. Dodson, David D. McManus, Mathew S. Maurer, Jonathan R. Enriquez, et al. “Association of Cognitive Impairment With Treatment and Outcomes in Older Myocardial Infarction Patients: A Report From the NCDR Chest Pain-MI Registry..” J Am Heart Assoc 8, no. 17 (September 3, 2019). https://doi.org/10.1161/JAHA.119.012929.

PMID
31462138
Full Text

Alexander, Karen P., and John H. Alexander. “Safe and Effective Anticoagulation: What Does Drug Concentration Add?.” J Am Geriatr Soc 67, no. 9 (September 2019): 1772–73. https://doi.org/10.1111/jgs.15981.

PMID
31112619
Full Text

Ray, Kausik K., Helen M. Colhoun, Michael Szarek, Marie Baccara-Dinet, Deepak L. Bhatt, Vera A. Bittner, Andrzej J. Budaj, et al. “Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial..” Lancet Diabetes Endocrinol 7, no. 8 (August 2019): 618–28. https://doi.org/10.1016/S2213-8587(19)30158-5.

PMID
31272931
Full Text

Krishnaswami, Ashok, Michael A. Steinman, Parag Goyal, Andrew R. Zullo, Timothy S. Anderson, Kim K. Birtcher, Sarah J. Goodlin, et al. “Deprescribing in Older Adults With Cardiovascular Disease..” J Am Coll Cardiol 73, no. 20 (May 28, 2019): 2584–95. https://doi.org/10.1016/j.jacc.2019.03.467.

PMID
31118153
Full Text

Pages