Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Afilalo, J, Sharma, A, Zhang, S, Brennan, JM, Edwards, FH, Mack, MJ, McClurken, JB, Cleveland, JC, Smith, PK, Shahian, DM, Peterson, ED, and Alexander, KP. "Gait Speed and 1-Year Mortality Following Cardiac Surgery: A Landmark Analysis From the Society of Thoracic Surgeons Adult Cardiac Surgery Database." Journal of the American Heart Association 7, no. 23 (December 2018): e010139-null.

PMID
30571598
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Fanaroff, AC, Clare, R, Pieper, KS, Mahaffey, KW, Melloni, C, Green, J, Alexander, JH, Jones, WS, Harrison, RW, Mehta, RH, Povsic, TJ, Moreira, HG, Al-Khatib, SM, Roe, MT, Kong, DF, Mathews, R, Tricoci, P, Holman, RR, Wallentin, L, Held, C, Califf, RM, Alexander, KP, and Lopes, RD. "Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9,259 Deaths in 9 Trials." Circulation (November 28, 2018).

PMID
30586739
Full Text

Alexander, KP, Brouwer, MA, Mulder, H, Vinereanu, D, Lopes, RD, Proietti, M, Al-Khatib, SM, Hijazi, Z, Halvorsen, S, Hylek, EM, Verheugt, FWA, Alexander, JH, Wallentin, L, Granger, CB, and ARISTOTLE Investigators, . "Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial." American Heart Journal (November 22, 2018).

PMID
30579505
Full Text

Dodson, JA, Hochman, JS, Roe, MT, Chen, AY, Chaudhry, SI, Katz, S, Zhong, H, Radford, MJ, Udell, JA, Bagai, A, Fonarow, GC, Gulati, M, Enriquez, JR, Garratt, KN, and Alexander, KP. "The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction: Insights From the ACTION Registry." Jacc. Cardiovascular Interventions 11, no. 22 (November 2018): 2287-2296.

PMID
30466828
Full Text

Hernandez, AF, Green, JB, Janmohamed, S, D'Agostino, RB, Granger, CB, Jones, NP, Leiter, LA, Rosenberg, AE, Sigmon, KN, Somerville, MC, Thorpe, KM, McMurray, JJV, Del Prato, S, and Harmony Outcomes committees and investigators, . "Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial." Lancet (London, England) 392, no. 10157 (October 2, 2018): 1519-1529.

PMID
30291013
Full Text

Krishnaswami, A, Kim, DH, McCulloch, CE, Forman, DE, Maurer, MS, Alexander, KP, and Rich, MW. "Individual and Joint Effects of Pulse Pressure and Blood Pressure Treatment Intensity on Serious Adverse Events in the SPRINT Trial." The American Journal of Medicine 131, no. 10 (October 2018): 1220-1227.e1.

PMID
29940151
Full Text

Patel, A, Goodman, SG, Yan, AT, Alexander, KP, Wong, CL, Cheema, AN, Udell, JA, Kaul, P, D'Souza, M, Hyun, K, Adams, M, Weaver, J, Chew, DP, Brieger, D, and Bagai, A. "Frailty and Outcomes After Myocardial Infarction: Insights From the CONCORDANCE Registry." Journal of the American Heart Association 7, no. 18 (September 2018): e009859-null.

PMID
30371219
Full Text

Bangalore, S, Maron, DJ, Fleg, JL, O'Brien, SM, Herzog, CA, Stone, GW, Mark, DB, Spertus, JA, Alexander, KP, Sidhu, MS, Chertow, GM, Boden, WE, Hochman, JS, and ISCHEMIA-CKD Research Group, . "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design." American Heart Journal 205 (August 2018): 42-52.

PMID
30172098
Full Text

ISCHEMIA Trial Research Group, , Maron, DJ, Hochman, JS, O'Brien, SM, Reynolds, HR, Boden, WE, Stone, GW, Bangalore, S, Spertus, JA, Mark, DB, Alexander, KP, Shaw, L, Berger, JS, Ferguson, TB, Williams, DO, Harrington, RA, and Rosenberg, Y. "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design." American Heart Journal 201 (July 2018): 124-135.

PMID
29778671
Full Text

Miller, AP, Maurer, M, and Alexander, KP. "Geriatric Cardiology: Two Decades of Progress and Strategy for the Future." Journal of the American College of Cardiology 71, no. 25 (June 26, 2018): 2970-2973.

Full Text

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