Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Ray, Kausik K., Helen M. Colhoun, Michael Szarek, Marie Baccara-Dinet, Deepak L. Bhatt, Vera A. Bittner, Andrzej J. Budaj, et al. “Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial..” Lancet Diabetes Endocrinol 7, no. 8 (August 2019): 618–28. https://doi.org/10.1016/S2213-8587(19)30158-5.

PMID
31272931
Full Text

Krishnaswami, Ashok, Michael A. Steinman, Parag Goyal, Andrew R. Zullo, Timothy S. Anderson, Kim K. Birtcher, Sarah J. Goodlin, et al. “Deprescribing in Older Adults With Cardiovascular Disease..” J Am Coll Cardiol 73, no. 20 (May 28, 2019): 2584–95. https://doi.org/10.1016/j.jacc.2019.03.467.

PMID
31118153
Full Text

Alexander, Karen P., and John H. Alexander. “Safe and Effective Anticoagulation: What Does Drug Concentration Add?.” J Am Geriatr Soc, May 21, 2019. https://doi.org/10.1111/jgs.15981.

PMID
31112619
Full Text

Fanaroff, Alexander C., Kristi Prather, Amanda Brucker, Daniel Wojdyla, Linda Davidson-Ray, Daniel B. Mark, Redford B. Williams, et al. “Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris..” Am J Cardiol 123, no. 9 (May 1, 2019): 1399–1405. https://doi.org/10.1016/j.amjcard.2019.01.036.

PMID
30771861
Full Text

Dodson, John A., Alexandra M. Hajduk, Terrence E. Murphy, Mary Geda, Harlan M. Krumholz, Sui Tsang, Michael G. Nanna, et al. “Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction..” Circ Cardiovasc Qual Outcomes 12, no. 5 (May 2019). https://doi.org/10.1161/CIRCOUTCOMES.118.005320.

PMID
31010300
Full Text

Kaul, Padma, Karen P. Alexander, E Magnus Ohman, Anamaria Savu, Matthew T. Roe, Shaun G. Goodman, Keith A. Fox, et al. “Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial..” Can J Cardiol 35, no. 4 (April 2019): 430–37. https://doi.org/10.1016/j.cjca.2018.12.035.

PMID
30935633
Full Text

Hochman, Judith S., Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, Karen P. Alexander, Roxy Senior, William E. Boden, et al. “Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial..” Jama Cardiol 4, no. 3 (March 1, 2019): 273–86. https://doi.org/10.1001/jamacardio.2019.0014.

PMID
30810700
Full Text

Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials..” Circulation 139, no. 7 (February 12, 2019): 863–73. https://doi.org/10.1161/CIRCULATIONAHA.118.037202.

PMID
30586739
Full Text

Alexander, Karen P., Marc A. Brouwer, Hillary Mulder, Dragos Vinereanu, Renato D. Lopes, Marco Proietti, Sana M. Al-Khatib, et al. “Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial..” Am Heart J 208 (February 2019): 123–31. https://doi.org/10.1016/j.ahj.2018.09.017.

PMID
30579505
Full Text

Afilalo, Jonathan, Abhinav Sharma, Shuaiqi Zhang, J Matthew Brennan, Fred H. Edwards, Michael J. Mack, James B. McClurken, et al. “Gait Speed and 1-Year Mortality Following Cardiac Surgery: A Landmark Analysis From the Society of Thoracic Surgeons Adult Cardiac Surgery Database..” J Am Heart Assoc 7, no. 23 (December 4, 2018). https://doi.org/10.1161/JAHA.118.010139.

PMID
30571598
Full Text

Pages