Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Bangalore, S, Maron, DJ, Fleg, JL, O'Brien, SM, Herzog, CA, Stone, GW, Mark, DB, Spertus, JA, Alexander, KP, Sidhu, MS, Chertow, GM, Boden, WE, Hochman, JS, and ISCHEMIA-CKD Research Group, . "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design." American Heart Journal 205 (August 2018): 42-52.

PMID
30172098
Full Text

ISCHEMIA Trial Research Group, , Maron, DJ, Hochman, JS, O'Brien, SM, Reynolds, HR, Boden, WE, Stone, GW, Bangalore, S, Spertus, JA, Mark, DB, Alexander, KP, Shaw, L, Berger, JS, Ferguson, TB, Williams, DO, Harrington, RA, and Rosenberg, Y. "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design." American Heart Journal 201 (July 2018): 124-135.

PMID
29778671
Full Text

Krishnaswami, A, Kim, DH, McCulloch, CE, Forman, DE, Maurer, MS, Alexander, KP, and Rich, MW. "Individual and Joint Effects of Pulse Pressure and Blood Pressure Treatment Intensity on Serious Adverse Events in the SPRINT Trial." The American Journal of Medicine (June 27, 2018).

PMID
29940151
Full Text

Miller, AP, Maurer, M, and Alexander, KP. "Geriatric Cardiology: Two Decades of Progress and Strategy for the Future." Journal of the American College of Cardiology 71, no. 25 (June 26, 2018): 2970-2973.

Full Text

Gorodeski, EZ, Goyal, P, Hummel, SL, Krishnaswami, A, Goodlin, SJ, Hart, LL, Forman, DE, Wenger, NK, Kirkpatrick, JN, Alexander, KP, Geriatric Cardiology Section Leadership Council, and American College of Cardiology, . "Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future." Journal of the American College of Cardiology 71, no. 17 (May 2018): 1921-1936. (Review)

PMID
29699619
Full Text

Madhavan, MV, Gersh, BJ, Alexander, KP, Granger, CB, and Stone, GW. "Coronary Artery Disease in Patients ≥80 Years of Age." Journal of the American College of Cardiology 71, no. 18 (May 2018): 2015-2040. (Review)

PMID
29724356
Full Text

Bangalore, S, Maron, DJ, Reynolds, HR, Stone, GW, O'Brien, SM, Alexander, KP, and Hochman, JS. "ISCHEMIA: Establishing the Primary End Point." Circulation. Cardiovascular Quality and Outcomes 11, no. 5 (May 2018): e004791-null.

PMID
29752391
Full Text

Patel, KK, Arnold, SV, Jones, PG, Qintar, M, Alexander, KP, and Spertus, JA. "Relation of Age and Health-Related Quality of Life to Invasive Versus Ischemia-Guided Management of Patients with Non-ST Elevation Myocardial Infarction." The American Journal of Cardiology 121, no. 7 (April 2018): 789-795.

PMID
29397885
Full Text

Flint, K, Kennedy, K, Arnold, SV, Dodson, JA, Cresci, S, and Alexander, KP. "Slow Gait Speed and Cardiac Rehabilitation Participation in Older Adults After Acute Myocardial Infarction." Journal of the American Heart Association 7, no. 5 (February 24, 2018).

PMID
29478024
Full Text

Guimarães, PO, Leonardi, S, Huang, Z, Wallentin, L, de Werf, FV, Aylward, PE, Held, C, Harrington, RA, Moliterno, DJ, Armstrong, PW, White, HD, Alexander, KP, Lopes, RD, Mahaffey, KW, and Tricoci, P. "Clinical features and outcomes of patients with type 2 myocardial infarction: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial." American Heart Journal 196 (February 2018): 28-35.

PMID
29421012
Full Text

Pages