Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Bangalore, Sripal, David J. Maron, Sean M. O’Brien, Jerome L. Fleg, Evgeny I. Kretov, Carlo Briguori, Upendra Kaul, et al. “Management of Coronary Disease in Patients with Advanced Kidney Disease.” N Engl J Med 382, no. 17 (April 23, 2020): 1608–18. https://doi.org/10.1056/NEJMoa1915925.

PMID
32227756
Full Text

Spertus, John A., Philip G. Jones, David J. Maron, Sean M. O’Brien, Harmony R. Reynolds, Yves Rosenberg, Gregg W. Stone, et al. “Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1408–19. https://doi.org/10.1056/NEJMoa1916370.

PMID
32227753
Full Text

Maron, David J., Judith S. Hochman, Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, William E. Boden, Bernard R. Chaitman, et al. “Initial Invasive or Conservative Strategy for Stable Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1395–1407. https://doi.org/10.1056/NEJMoa1915922.

PMID
32227755
Full Text

Fanaroff, Alexander C., Ghazala Haque, Betsy Thomas, Allegra E. Stone, Lynn M. Perkins, Matthew Wilson, W Schuyler Jones, et al. “Methods for safety and endpoint ascertainment: identification of adverse events through scrutiny of negatively adjudicated events.” Trials 21, no. 1 (April 9, 2020): 323. https://doi.org/10.1186/s13063-020-04254-w.

PMID
32272961
Full Text

Wenger, Nanette K., and Karen P. Alexander. “Not your grandparents' cardiac care: The future of geriatric cardiology.” Clin Cardiol 43, no. 2 (February 2020): 90–91. https://doi.org/10.1002/clc.23270.

PMID
31580479
Full Text

Damluji, Abdulla A., Daniel E. Forman, Sean van Diepen, Karen P. Alexander, Robert L. Page, Scott L. Hummel, Venu Menon, et al. “Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association.” Circulation 141, no. 2 (January 14, 2020): e6–32. https://doi.org/10.1161/CIR.0000000000000741.

PMID
31813278
Full Text

Nanna, Michael G., Eric D. Peterson, Angie Wu, Tina Harding, Anthony N. Galanos, Lisa Wruck, and Karen P. Alexander. “Age, knowledge, preferences, and risk tolerance for invasive cardiac care.” Am Heart J 219 (January 2020): 99–108. https://doi.org/10.1016/j.ahj.2019.09.008.

PMID
31733450
Full Text

Starks, Monique Anderson, and Karen Alexander. “In Anticipation of the Inevitable: Preparing Older Americans for Cardiac Arrest.” J Am Geriatr Soc 68, no. 1 (January 2020): 9–10. https://doi.org/10.1111/jgs.16269.

PMID
31840229
Full Text

Goyal, Parag, Eiran Z. Gorodeski, Kelsey M. Flint, Deena S. Goldwater, John A. Dodson, Jonathan Afilalo, Mathew S. Maurer, Michael W. Rich, Karen P. Alexander, and Scott L. Hummel. “Perspectives on Implementing a Multidomain Approach to Caring for Older Adults With Heart Failure.” J Am Geriatr Soc 67, no. 12 (December 2019): 2593–99. https://doi.org/10.1111/jgs.16183.

PMID
31625160
Full Text

Lowenstern, Angela, Karen P. Alexander, C Larry Hill, Brooke Alhanti, Patricia A. Pellikka, Michael G. Nanna, Rajendra H. Mehta, et al. “Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights From the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial.” Jama Cardiol, November 18, 2019. https://doi.org/10.1001/jamacardio.2019.4973.

PMID
31738382
Full Text

Pages