Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris St, Durham, NC 27701
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Lopes, Renato D., Karen P. Alexander, Susanna R. Stevens, Harmony R. Reynolds, Gregg W. Stone, Ileana L. Piña, Frank W. Rockhold, et al. “Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial.” Circulation 142, no. 18 (November 3, 2020): 1725–35. https://doi.org/10.1161/CIRCULATIONAHA.120.050304.

PMID
32862662
Full Text

Greenland, Philip, Erin D. Michos, Nicole Redmond, Lawrence J. Fine, Karen P. Alexander, Walter T. Ambrosius, Kirsten Bibbins-Domingo, et al. “Primary Prevention Trial Designs Using Coronary Imaging: A National Heart, Lung, and Blood Institute Workshop.” Jacc Cardiovasc Imaging, September 11, 2020. https://doi.org/10.1016/j.jcmg.2020.06.042.

PMID
32950442
Full Text

Lowenstern, Angela, Karen P. Alexander, and Pamela S. Douglas. “Should We Simplify Computed Tomography Angiography Reporting as Black or White vs Describing All Shades of Gray?-Reply.” Jama Cardiol, September 9, 2020. https://doi.org/10.1001/jamacardio.2020.3733.

PMID
32902566
Full Text

Rasmussen, Peter Vibe, Jannik Langtved Pallisgaard, Morten Lock Hansen, Gunnar Hilmar Gislason, Christian Torp-Pedersen, Martin Ruwald, Karen P. Alexander, Renato D. Lopes, Sana M. Al-Khatib, and Frederik Dalgaard. “Treatment of Older Patients with Atrial Fibrillation by Morbidity Burden.” Eur Heart J Qual Care Clin Outcomes, August 28, 2020. https://doi.org/10.1093/ehjqcco/qcaa070.

PMID
32857834
Full Text

Maron, David J., Judith S. Hochman, Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, William E. Boden, Bernard R. Chaitman, et al. “Initial Invasive or Conservative Strategy for Stable Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1395–1407. https://doi.org/10.1056/NEJMoa1915922.

PMID
32227755
Full Text

Fanaroff, Alexander C., Ghazala Haque, Betsy Thomas, Allegra E. Stone, Lynn M. Perkins, Matthew Wilson, W Schuyler Jones, et al. “Methods for safety and endpoint ascertainment: identification of adverse events through scrutiny of negatively adjudicated events.” Trials 21, no. 1 (April 9, 2020): 323. https://doi.org/10.1186/s13063-020-04254-w.

PMID
32272961
Full Text

Spertus, John A., Philip G. Jones, David J. Maron, Sean M. O’Brien, Harmony R. Reynolds, Yves Rosenberg, Gregg W. Stone, et al. “Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.” The New England Journal of Medicine 382, no. 15 (April 2020): 1408–19. https://doi.org/10.1056/nejmoa1916370.

PMID
32227753
Full Text

Bangalore, Sripal, David J. Maron, Sean M. O’Brien, Jerome L. Fleg, Evgeny I. Kretov, Carlo Briguori, Upendra Kaul, et al. “Management of Coronary Disease in Patients with Advanced Kidney Disease.” The New England Journal of Medicine 382, no. 17 (April 2020): 1608–18. https://doi.org/10.1056/nejmoa1915925.

PMID
32227756
Full Text

Wenger, Nanette K., and Karen P. Alexander. “Not your grandparents' cardiac care: The future of geriatric cardiology.” Clin Cardiol 43, no. 2 (February 2020): 90–91. https://doi.org/10.1002/clc.23270.

PMID
31580479
Full Text

Lowenstern, Angela, Karen P. Alexander, C Larry Hill, Brooke Alhanti, Patricia A. Pellikka, Michael G. Nanna, Rajendra H. Mehta, et al. “Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights From the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial.” Jama Cardiology 5, no. 2 (February 2020): 193–201. https://doi.org/10.1001/jamacardio.2019.4973.

PMID
31738382
Full Text

Pages