Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Shah, S. H., K. P. Alexander, and E. D. Peterson. “PCI in women.” Cardiology Review 20, no. 3 (March 1, 2003): 24–29.

Scholars@Duke

Shah, Svati H., and Karen P. Alexander. “Hormone Replacement Therapy for Primary and Secondary Prevention of Heart Disease..” Curr Treat Options Cardiovasc Med 5, no. 1 (February 2003): 25–33.

PMID
12686016
Scholars@Duke

Biswas, M. S., E. L. Eisenstein, and K. P. Alexander. “The right test for the right price.” In Circulation, 106:759–759. LIPPINCOTT WILLIAMS & WILKINS, 2002.

Scholars@Duke

Pasquali, S. K., K. P. Alexander, L. P. Coombs, B. L. Lytle, and E. D. Peterson. “Effect of cardiac rehabilitation on functional outcomes following coronary revascularization.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 151A-151A.

Scholars@Duke

Alexander, K. P., T. Harding, L. P. Coombs, K. Taylor, and E. D. Peterson. “Aging and patient preferences regarding invasive cardiac care.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 197A-197A.

Scholars@Duke

Alexander, K. P., M. V. Bhapkar, H. D. White, J. S. Hochman, M. E. Pfisterer, D. J. Moliterno, R. M. Califf, et al. “Paradoxical use of angiography with advancing age: Insights from an international trial population.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 152A-152A.

Scholars@Duke

Pasquali, S. K., K. P. Alexander, B. L. Lytle, L. P. Coombs, and E. D. Peterson. “Testing an intervention to increase cardiac rehabilitation enrollment after coronary artery bypass grafting..” Am J Cardiol 88, no. 12 (December 15, 2001): 1415-A6. https://doi.org/10.1016/s0002-9149(01)02123-3.

PMID
11741563
Full Text

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