Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Wayangankar, S. A., M. T. Roe, A. Y. Chen, R. S. Gupta, R. P. Giugliano, L. K. Newby, J. A. de Lemos, K. P. Alexander, T. A. Sanborn, and J. F. Saucedo. “Trends in use of anti-thrombotic agents and outcomes in patients with non-ST-segment elevation myocardial infarction (NSTEMI) managed with an invasive strategy..” Indian Heart J 68, no. 4 (July 2016): 464–72. https://doi.org/10.1016/j.ihj.2015.09.036.

PMID
27543467
Full Text

Afilalo, Jonathan, Sunghee Kim, Sean O’Brien, J Matthew Brennan, Fred H. Edwards, Michael J. Mack, James B. McClurken, et al. “Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery..” Jama Cardiol 1, no. 3 (June 1, 2016): 314–21. https://doi.org/10.1001/jamacardio.2016.0316.

PMID
27438112
Full Text

White, Harvey D., Cynthia M. Westerhout, Karen P. Alexander, Matthew T. Roe, Kenneth J. Winters, Derek D. Cyr, Keith Aa Fox, et al. “Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial..” Eur Heart J Acute Cardiovasc Care 5, no. 3 (June 2016): 231–42. https://doi.org/10.1177/2048872615581502.

PMID
25897147
Full Text

Rich, Michael W., Deborah A. Chyun, Adam H. Skolnick, Karen P. Alexander, Daniel E. Forman, Dalane W. Kitzman, Mathew S. Maurer, et al. “Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society..” J Am Coll Cardiol 67, no. 20 (May 24, 2016): 2419–40. https://doi.org/10.1016/j.jacc.2016.03.004.

PMID
27079335
Full Text

Rich, Michael W., Deborah A. Chyun, Adam H. Skolnick, Karen P. Alexander, Daniel E. Forman, Dalane W. Kitzman, Mathew S. Maurer, et al. “Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society..” Circulation 133, no. 21 (May 24, 2016): 2103–22. https://doi.org/10.1161/CIR.0000000000000380.

PMID
27067230
Full Text

Alexander, Karen P., Olena Stadnyuk, Suzanne V. Arnold, Daniel B. Mark, E Magnus Ohman, and Kevin J. Anstrom. “Assessing Quality of Life and Medical Care in Chronic Angina: An Internet Survey..” Interact J Med Res 5, no. 2 (April 28, 2016). https://doi.org/10.2196/ijmr.4971.

PMID
27125492
Full Text

Kragholm, Kristian, Sarah A. Goldstein, Qinghong Yang, Renato D. Lopes, Phillip J. Schulte, Gwen M. Bernacki, Harvey D. White, et al. “Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials..” Circulation 133, no. 16 (April 19, 2016): 1560–73. https://doi.org/10.1161/CIRCULATIONAHA.115.017299.

PMID
26957532
Full Text

Alfredsson, Joakim, Amanda Stebbins, J Matthew Brennan, Roland Matsouaka, Jonathan Afilalo, Eric D. Peterson, Sreekanth Vemulapalli, et al. “Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry..” Circulation 133, no. 14 (April 5, 2016): 1351–59. https://doi.org/10.1161/CIRCULATIONAHA.115.020279.

PMID
26920495
Full Text

Melloni, Chiara, and Karen P. Alexander. “Exploring the Nexus Between Chronic Kidney Disease and Cardiovascular Disease..” Eur Heart J Qual Care Clin Outcomes 2, no. 2 (April 1, 2016): 62–63. https://doi.org/10.1093/ehjqcco/qcw009.

PMID
29474629
Full Text

Pages