Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alfredsson, J, and Alexander, KP. "Multiple Chronic Conditions in Older Adults with Acute Coronary Syndromes." Clinics in Geriatric Medicine 32, no. 2 (May 2016): 291-303. (Review)

PMID
27113147
Full Text

Kragholm, K, Goldstein, SA, Yang, Q, Lopes, RD, Schulte, PJ, Bernacki, GM, White, HD, Mahaffey, KW, Giugliano, RP, Armstrong, PW, Harrington, RA, Tricoci, P, Van de Werf, F, Alexander, JH, Alexander, KP, and Newby, LK. "Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials." CIRCULATION 133, no. 16 (April 19, 2016): 1560-+.

Full Text

Kragholm, K, Goldstein, SA, Yang, Q, Lopes, RD, Schulte, PJ, Bernacki, GM, White, HD, Mahaffey, KW, Giugliano, RP, Armstrong, PW, Harrington, RA, Tricoci, P, Van de Werf, F, Alexander, JH, Alexander, KP, and Newby, LK. "Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials." Circulation 133, no. 16 (April 2016): 1560-1573.

PMID
26957532
Full Text

Alfredsson, J, Stebbins, A, Brennan, JM, Matsouaka, R, Afilalo, J, Peterson, ED, Vemulapalli, S, Rumsfeld, JS, Shahian, D, Mack, MJ, and Alexander, KP. "Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry." Circulation 133, no. 14 (April 2016): 1351-1359.

PMID
26920495
Full Text

Zimerman, A, Lopes, RD, Stebbins, AL, Guimarães, PO, Haque, G, Melloni, C, Trollinger, K, James, SK, Alexander, JH, Tricoci, P, Roe, MT, Ohman, EM, Mahaffey, KW, Held, C, Tinga, B, Pieper, KS, and Alexander, KP. "Pooled analysis of adverse event collection from 4 acute coronary syndrome trials." American Heart Journal 174 (April 2016): 60-67.

PMID
26995371
Full Text

Melloni, C, and Alexander, KP. "Exploring the Nexus Between Chronic Kidney Disease and Cardiovascular Disease." European Heart Journal. Quality of Care & Clinical Outcomes 2, no. 2 (April 2016): 62-63.

PMID
29474629
Full Text

Dodson, JA, Arnold, SV, Gosch, KL, Gill, TM, Spertus, JA, Krumholz, HM, Rich, MW, Chaudhry, SI, Forman, DE, Masoudi, FA, and Alexander, KP. "Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry." Journal of the American Geriatrics Society 64, no. 3 (March 2016): 596-601.

PMID
26926309
Full Text

Dai, X, Busby-Whitehead, J, and Alexander, KP. "Acute coronary syndrome in the older adults." Journal of Geriatric Cardiology : Jgc 13, no. 2 (February 2016): 101-108.

PMID
27168733
Full Text

Dai, X, Busby-Whitehead, J, Forman, DE, and Alexander, KP. "Stable ischemic heart disease in the older adults." Journal of Geriatric Cardiology : Jgc 13, no. 2 (February 2016): 109-114.

PMID
27168734
Full Text

Forman, DE, Alexander, K, Brindis, RG, Curtis, AB, Maurer, M, Rich, MW, Sperling, L, and Wenger, NK. "Improved Cardiovascular Disease Outcomes in Older Adults." F1000research 5 (January 1, 2016). (Review)

Full Text

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