Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Bagai, Akshay, Karen P. Alexander, Jeffrey S. Berger, Roxy Senior, Chakkanalil Sajeev, Radoslaw Pracon, Kreton Mavromatis, et al. “Use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis.” Am Heart J 190 (August 2017): 135–39. https://doi.org/10.1016/j.ahj.2017.04.016.

PMID
28760208
Full Text

Neeland, Ian J., Sandeep R. Das, DaJuanicia N. Simon, Deborah B. Diercks, Karen P. Alexander, Tracy Y. Wang, and James A. de Lemos. “The obesity paradox, extreme obesity, and long-term outcomes in older adults with ST-segment elevation myocardial infarction: results from the NCDR.” Eur Heart J Qual Care Clin Outcomes 3, no. 3 (July 1, 2017): 183–91. https://doi.org/10.1093/ehjqcco/qcx010.

PMID
28838094
Full Text

Posenau, J Trevor, Daniel M. Wojdyla, Linda K. Shaw, Karen P. Alexander, E Magnus Ohman, Manesh R. Patel, Peter K. Smith, and Sunil V. Rao. “Revascularization Strategies and Outcomes in Elderly Patients With Multivessel Coronary Disease.” Ann Thorac Surg 104, no. 1 (July 2017): 107–15. https://doi.org/10.1016/j.athoracsur.2016.10.053.

PMID
28109574
Full Text

Fanaroff, Alexander C., Stefan K. James, Giora Weisz, Kristi Prather, Kevin J. Anstrom, Daniel B. Mark, Ori Ben-Yehuda, Karen P. Alexander, Gregg W. Stone, and E Magnus Ohman. “Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial.” J Am Coll Cardiol 69, no. 18 (May 9, 2017): 2304–13. https://doi.org/10.1016/j.jacc.2017.02.056.

PMID
28473136
Full Text

Guimarães, Patrícia O., Renato D. Lopes, Susanna R. Stevens, André Zimerman, Lisa Wruck, Stefan K. James, Ghazala Haque, Roberto Rocha C. V. Giraldez, John H. Alexander, and Karen P. Alexander. “Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection.” J Am Heart Assoc 6, no. 4 (April 24, 2017). https://doi.org/10.1161/JAHA.117.005490.

PMID
28438739
Full Text

Sharma, Abhinav, and Karen P. Alexander. “Natriuretic Peptides in Older Patients With Heart Failure: A Look Into the Seeds of Time.” J Am Geriatr Soc 65, no. 4 (April 2017): 691–92. https://doi.org/10.1111/jgs.14762.

PMID
28176304
Full Text

Otto, Catherine M., Dharam J. Kumbhani, Karen P. Alexander, John H. Calhoon, Milind Y. Desai, Sanjay Kaul, James C. Lee, Carlos E. Ruiz, and Christina M. Vassileva. “2017 ACC Expert Consensus Decision Pathway for Transcatheter Aortic Valve Replacement in the Management of Adults With Aortic Stenosis: A Report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents.” J Am Coll Cardiol 69, no. 10 (March 14, 2017): 1313–46. https://doi.org/10.1016/j.jacc.2016.12.006.

PMID
28063810
Full Text

Pages