Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, KP, Prather, K, Anstrom, KJ, Mark, D, Ben-Yehuda, O, Davidson-Ray, L, Weisz, G, Farzaneh-Far, R, Stone, G, and Ohman, EM. "Angina and Quality of Life Following PCI With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial." December 8, 2015.

Scholars@Duke

Kang, H-J, Simon, D, Wang, TY, Alexander, KP, Jeong, MH, Kim, H-S, Bates, ER, Henry, TD, Peterson, ED, Roe, MT, and National Cardiovascular Data Registry, . "The Contemporary Use of Angiography and Revascularization Among Patients With Non-ST-Segment Elevation Myocardial Infarction in the United States Compared With South Korea." Clinical cardiology 38, no. 12 (December 2015): 708-714.

PMID
26782938
Full Text

Kang, H-J, Simon, D, Wang, TY, Alexander, KP, Jeong, MH, Kim, H-S, Bates, ER, Henry, TD, Peterson, ED, Roe, MT, and Registry, NCD. "The Contemporary Use of Angiography and Revascularization Among Patients With Non-ST-Segment Elevation Myocardial Infarction in the United States Compared With South Korea." CLINICAL CARDIOLOGY 38, no. 12 (December 2015): 708-714.

Full Text

Shen, L, Shah, BR, Li, S, Thomas, L, Wang, TY, Alexander, KP, Peterson, ED, He, B, and Roe, MT. "The Association of Transfer Rate From Hospitals Without Revascularization Capabilities and Mortality Risk for Older Non-ST-Segment Elevation Myocardial Infarction Patients." Clinical cardiology 38, no. 12 (December 2015): 733-739.

PMID
26511331
Full Text

Zimerman, A, Stebbins, AL, Lopes, RD, Guimaraes, PO, James, SK, Alexander, JH, Tricoci, P, Roe, MT, Ohman, EM, Mahaffey, KW, Held, C, Tinga, B, Pieper, KS, and Alexander, KP. 48,000 Participants in Four Acute Coronary Syndrome Trials." November 10, 2015.

Scholars@Duke

Skolnick, AH, and Alexander, KP. "Older Adults in Clinical Research and Drug Development: Closing the Geriatric Gap." Circulation. Cardiovascular quality and outcomes 8, no. 6 (November 2015): 631-633.

PMID
26487738
Full Text

Swiger, KJ, Martin, SS, Tang, F, Blaha, MJ, Blumenthal, RS, Alexander, KP, Arnold, SV, and Spertus, JA. "Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction." Clinical Cardiology 38, no. 8 (August 1, 2015): 455-461.

Full Text

Swiger, KJ, Martin, SS, Tang, F, Blaha, MJ, Blumenthal, RS, Alexander, KP, Arnold, SV, and Spertus, JA. "Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction." Clinical cardiology 38, no. 8 (August 2015): 455-461.

PMID
26212493
Full Text

Gupta, A, Chui, P, Zhou, S, Spertus, JA, Geda, M, Lorenze, N, Lee, I, D' Onofrio, G, Lichtman, JH, Alexander, KP, Krumholz, HM, and Curtis, JP. "Frequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study)." The American journal of cardiology 116, no. 1 (July 2015): 1-7.

PMID
25937348
Full Text

Arnold, SV, Li, S-X, Alexander, KP, Spertus, JA, Nallamothu, BK, Curtis, JP, Kosiborod, M, Gupta, A, Wang, TY, Lin, H, Dharmarajan, K, Strait, KM, Lowe, TJ, and Krumholz, HM. "Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy." Journal of the American Heart Association 4, no. 6 (June 15, 2015): e002009-.

PMID
26077589
Full Text

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