Medical Oncology

Kathleen Ann Cooney, MD

Professor of Medicine
George Barth Geller Distinguished Professor of Medicine
Chair, Department of Medicine
Member of the Duke Cancer Institute
Campus mail 2301 Erwin Road, Duke Hospital North Suite 1102, Durham, NC 27710
Phone (919) 681-2452
Email address kathleen.cooney@duke.edu

Dr. Cooney is Chair of the Duke Department of Medicine.

She is a medical oncologist focused in caring for men with prostate cancer, and is internationally known for her investigations focused on the genetic epidemiology of prostate cancer.

Her research led to the important discovery of a recurrent mutation in the HOXB13 gene that increases the chances of being diagnosed with prostate cancer and is estimated to account for 5 percent of hereditary prostate cancer cases worldwide. Since men with HOXB13 mutations are at an increased risk of prostate cancer, they may benefit from participation in screening and potentially prevention protocols in the future.

Dr. Cooney’s research continues with federal funding to identify germline mutations associated with lethal and aggressive prostate cancer as well as prostate cancer in African American men.

Education and Training

  • Fellow, Hematology / Oncology, University of Michigan, Ann Arbor, 1988 - 1991
  • Chief Medical Resident, Internal Medicine, University of Michigan, Ann Arbor, 1987 - 1988
  • Intern/Resident, Internal Medicine, University of Michigan, Ann Arbor, 1984 - 1987
  • M.D., University of Pennsylvania, School of Medicine, 1984

Grants

Publications

Shi, Zhuqing, Elizabeth A. Platz, Jun Wei, Rong Na, Richard J. Fantus, Chi-Hsiung Wang, Scott E. Eggener, et al. “Performance of Three Inherited Risk Measures for Predicting Prostate Cancer Incidence and Mortality: A Population-based Prospective Analysis.” Eur Urol 79, no. 3 (March 2021): 419–26. https://doi.org/10.1016/j.eururo.2020.11.014.

PMID
33257031
Full Text

Schaid, Daniel J., Shannon K. McDonnell, Liesel M. FitzGerald, Lissa DeRycke, Zachary Fogarty, Graham G. Giles, Robert J. MacInnis, et al. “Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.” Eur Urol 79, no. 3 (March 2021): 353–61. https://doi.org/10.1016/j.eururo.2020.07.038.

PMID
32800727
Full Text

Darst, Burcu F., Peggy Wan, Xin Sheng, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, et al. “A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry.” Eur Urol 78, no. 3 (September 2020): 316–20. https://doi.org/10.1016/j.eururo.2020.04.060.

PMID
32409115
Full Text

Smith, David C., Stephanie Daignault-Newton, Petros Grivas, Zachery R. Reichert, Maha Hussain, Kathleen A. Cooney, Megan Caram, et al. “Efficacy and Effect of Cabozantinib on Bone Metastases in Treatment-naive Castration-resistant Prostate Cancer.” Clin Genitourin Cancer 18, no. 4 (August 2020): 332-339.e2. https://doi.org/10.1016/j.clgc.2019.10.019.

PMID
32299729
Full Text

Beebe-Dimmer, Jennifer L., Ashley L. Kapron, Alison M. Fraser, Ken R. Smith, and Kathleen A. Cooney. “Risk of Prostate Cancer Associated With Familial and Hereditary Cancer Syndromes.” J Clin Oncol 38, no. 16 (June 1, 2020): 1807–13. https://doi.org/10.1200/JCO.19.02808.

PMID
32208047
Full Text

Oswald, Nathaniel, Tengda Lin, Benjamin Haaland, Michael Flynn, Kensaku Kawamoto, Kathleen A. Cooney, William Lowrance, Heidi A. Hanson, and Brock O’Neil. “Factors associated with appropriate and low-value PSA testing.” Cancer Epidemiol 66 (June 2020): 101724. https://doi.org/10.1016/j.canep.2020.101724.

PMID
32361642
Full Text

Wu, Yishuo, Hongjie Yu, Shuwei Li, Kathleen Wiley, S Lilly Zheng, Holly LaDuca, Marta Gielzak, et al. “Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer.” Eur Urol Oncol 3, no. 2 (April 2020): 224–30. https://doi.org/10.1016/j.euo.2019.12.003.

PMID
31948886
Full Text

Jalali, Ali, Christopher Martin, Richard E. Nelson, Megan E. Vanneman, Brook I. Martin, Kathleen A. Cooney, Norman J. Waitzman, and Brock O’Neil. “Provider Practice Competition and Adoption of Medicare's Oncology Care Model.” Med Care 58, no. 2 (February 2020): 154–60. https://doi.org/10.1097/MLR.0000000000001243.

PMID
31688568
Full Text

Isaacs, William B., Kathleen A. Cooney, and Jianfeng Xu. “Updated insights into genetic contribution to prostate cancer predisposition: focus on HOXB13.” Can J Urol 26, no. 5 Suppl 2 (October 2019): 12–13.

PMID
31629417
Scholars@Duke

Boyle, Julie, and Kathleen A. Cooney. “DNA repair genes: contributions to prostate cancer predisposition and aggressiveness.” Can J Urol 26, no. 5 Suppl 2 (October 2019): 10–11.

PMID
31629416
Scholars@Duke

Pages