Kathleen Ann Cooney, MD

Professor of Medicine
Chair, Department of Medicine
Member of the Duke Cancer Institute
Campus mail 2301 Erwin Road Suite 1102, DUMC 3703, Durham, NC 27710
Phone (919) 681-2452
Email address kathleen.cooney@duke.edu

Dr. Cooney is Chair of the Duke Department of Medicine.

She is a medical oncologist focused in caring for men with prostate cancer, and is internationally known for her investigations focused on the genetic epidemiology of prostate cancer.

Her research led to the important discovery of a recurrent mutation in the HOXB13 gene that increases the chances of being diagnosed with prostate cancer and is estimated to account for 5 percent of hereditary prostate cancer cases worldwide. Since men with HOXB13 mutations are at an increased risk of prostate cancer, they may benefit from participation in screening and potentially prevention protocols in the future.

Dr. Cooney’s research continues with federal funding to identify germline mutations associated with lethal and aggressive prostate cancer as well as prostate cancer in African American men.

Education and Training

  • Fellow, Hematology / Oncology, University of Michigan at Ann Arbor, 1988 - 1991
  • Chief Medical Resident, Internal Medicine, University of Michigan at Ann Arbor, 1987 - 1988
  • Intern/Resident, Internal Medicine, University of Michigan at Ann Arbor, 1984 - 1987
  • M.D., University of Pennsylvania School of Medicine, 1984

Publications

Cooney, KA, and Beebe-Dimmer, JL. "Finding a Needle in the Haystack: The Search for Germline Variants Associated with Prostate Cancer Clinical Outcomes." European Urology 74, no. 6 (December 2018): 720-721.

PMID
30029823
Full Text

Wu, Y, Yu, H, Zheng, SL, Feng, B, Kapron, AL, Na, R, Boyle, JL, Shah, S, Shi, Z, Ewing, CM, Wiley, KE, Luo, J, Walsh, PC, Carter, HB, Helfand, BT, Cooney, KA, Xu, J, and Isaacs, WB. "Germline mutations in PPFIBP2 are associated with lethal prostate cancer." The Prostate 78, no. 16 (December 2018): 1222-1228.

PMID
30043417
Full Text

O’Neil, B, Martin, C, Kapron, A, Flynn, M, Kawamoto, K, and Cooney, KA. "Defining low-value PSA testing in a large retrospective cohort: Finding common ground between discordant guidelines." Cancer Epidemiology 56 (October 2018): 112-117.

Full Text

Pilié, PG, and Cooney, KA. "Broadening the View of Germline Mutations in Kidney Cancer." Jama Oncology 4, no. 9 (September 1, 2018): 1235-1235.

Full Text

Wu, Y, Yu, H, Zheng, SL, Na, R, Mamawala, M, Landis, T, Wiley, K, Petkewicz, J, Shah, S, Shi, Z, Novakovic, K, McGuire, M, Brendler, CB, Ding, Q, Helfand, BT, Carter, HB, Cooney, KA, Isaacs, WB, and Xu, J. "A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer." Prostate 78, no. 8 (June 1, 2018): 607-615.

Full Text

Hussain, M, Daignault-Newton, S, Twardowski, PW, Albany, C, Stein, MN, Kunju, LP, Siddiqui, J, Wu, Y-M, Robinson, D, Lonigro, RJ, Cao, X, Tomlins, SA, Mehra, R, Cooney, KA, Montgomery, B, Antonarakis, ES, Shevrin, DH, Corn, PG, Whang, YE, Smith, DC, Caram, MV, Knudsen, KE, Stadler, WM, Feng, FY, and Chinnaiyan, AM. "Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 36, no. 10 (April 2018): 991-999.

PMID
29261439
Full Text

Beebe-Dimmer, JL, Zuhlke, KA, Johnson, AM, Liesman, D, and Cooney, KA. "Rare germline mutations in African American men diagnosed with early-onset prostate cancer." The Prostate 78, no. 5 (April 2018): 321-326.

PMID
29356034
Full Text

Giri, VN, Knudsen, KE, Kelly, WK, Abida, W, Andriole, GL, Bangma, CH, Bekelman, JE, Benson, MC, Blanco, A, Burnett, A, Catalona, WJ, Cooney, KA, Cooperberg, M, Crawford, DE, Den, RB, Dicker, AP, Eggener, S, Fleshner, N, Freedman, ML, Hamdy, FC, Hoffman-Censits, J, Hurwitz, MD, Hyatt, C, Isaacs, WB, Kane, CJ, Kantoff, P, Karnes, RJ, Karsh, LI, Klein, EA, Lin, DW, Loughlin, KR, Lu-Yao, G, Malkowicz, SB, Mann, MJ, Mark, JR, McCue, PA, Miner, MM, Morgan, T, Moul, JW, Myers, RE, Nielsen, SM, Obeid, E, Pavlovich, CP, Peiper, SC, Penson, DF, Petrylak, D, Pettaway, CA, Pilarski, R, Pinto, PA, Poage, W, Raj, GV, Rebbeck, TR, Robson, ME, Rosenberg, MT, Sandler, H, Sartor, O, Schaeffer, E, Schwartz, GF, Shahin, MS, Shore, ND, Shuch, B, Soule, HR, Tomlins, SA, Trabulsi, EJ, Uzzo, R, Vander Griend, DJ, Walsh, PC, Weil, CJ, Wender, R, and Gomella, LG. "Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 36, no. 4 (February 2018): 414-424.

PMID
29236593
Full Text

Chen, H, Ewing, CM, Zheng, S, Grindedaal, EM, Cooney, KA, Wiley, K, Djurovic, S, Andreassen, OA, Axcrona, K, Mills, IG, Xu, J, Maehle, L, Fosså, SD, and Isaacs, WB. "Genetic factors influencing prostate cancer risk in Norwegian men." The Prostate 78, no. 3 (February 2018): 186-192.

PMID
29181843
Full Text

Grivas, PD, Devata, S, Khoriaty, R, Boonstra, PS, Ruch, J, McDonnell, K, Hernandez-Aya, L, Wilfong, J, Smerage, J, Ison, MG, Eisenberg, JNS, Silveira, M, Cooney, KA, and Worden, FP. "Low-Cost Intervention to Increase Influenza Vaccination Rate at a Comprehensive Cancer Center." Journal of Cancer Education : the Official Journal of the American Association for Cancer Education 32, no. 4 (December 2017): 871-877.

PMID
27055536
Full Text

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