Medical Oncology

Kathleen Ann Cooney, MD

Professor of Medicine
George Barth Geller Distinguished Professor of Medicine
Chair, Department of Medicine
Member of the Duke Cancer Institute
Campus mail 40 Duke Medicine Circle, Davison Bldg, Suite 401, 401A, Durham, NC 27710
Phone (919) 681-2452
Email address kathleen.cooney@duke.edu

Dr. Cooney is Chair of the Duke Department of Medicine and Interim Director of the Duke Center for Applied Genomics and Precision Medicine.

She is a medical oncologist focused in caring for men with prostate cancer, and is internationally known for her investigations focused on the genetic epidemiology of prostate cancer.

Her research led to the important discovery of a recurrent mutation in the HOXB13 gene that increases the chances of being diagnosed with prostate cancer and is estimated to account for 5 percent of hereditary prostate cancer cases worldwide. Since men with HOXB13 mutations are at an increased risk of prostate cancer, they may benefit from participation in screening and potentially prevention protocols in the future.

Dr. Cooney’s research continues with federal funding to identify germline mutations associated with lethal and aggressive prostate cancer as well as prostate cancer in African American men.

Education and Training

  • Fellow, Hematology / Oncology, University of Michigan, Ann Arbor, 1988 - 1991
  • Chief Medical Resident, Internal Medicine, University of Michigan, Ann Arbor, 1987 - 1988
  • Intern/Resident, Internal Medicine, University of Michigan, Ann Arbor, 1984 - 1987
  • M.D., University of Pennsylvania, School of Medicine, 1984

Grants

Publications

Na, Rong, Jun Wei, Chris J. Sample, Marta Gielzak, Sodam Choi, Kathleen A. Cooney, Daniel Rabizadeh, et al. “The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients.” Br J Cancer 126, no. 5 (March 2022): 791–96. https://doi.org/10.1038/s41416-021-01622-4.

PMID
34799695
Full Text

Xu, Jianfeng, Zhuqing Shi, Jun Wei, Rong Na, W Kyle Resurreccion, Chi-Hsiung Wang, Chris Sample, et al. “KLK3 germline mutation I179T complements DNA repair genes for predicting prostate cancer progression.” Prostate Cancer Prostatic Dis, February 11, 2022. https://doi.org/10.1038/s41391-021-00466-6.

PMID
35149774
Full Text

Shi, Zhuqing, Lucy Lu, William Kyle Resurreccion, Wancai Yang, Jun Wei, Qiang Wang, Valentina Engelmann, et al. “Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis.” Prostate 82, no. 1 (January 2022): 107–19. https://doi.org/10.1002/pros.24252.

PMID
34674288
Full Text

Bancroft, Elizabeth K., Elizabeth C. Page, Mark N. Brook, Sarah Thomas, Natalie Taylor, Jennifer Pope, Jana McHugh, et al. “A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.” Lancet Oncol 22, no. 11 (November 2021): 1618–31. https://doi.org/10.1016/S1470-2045(21)00522-2.

PMID
34678156
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Wei, Jun, Wancai Yang, Zhuqing Shi, Lucy Lu, Qiang Wang, W Kyle Resurreccion, Valentina Engelmann, et al. “Observed evidence for guideline-recommended genes in predicting prostate cancer risk from a large population-based cohort.” Prostate 81, no. 13 (September 2021): 1002–8. https://doi.org/10.1002/pros.24195.

PMID
34254341
Full Text

Sata, Suchita Shah, Brittany Vekstein, Laura Svetkey, Lisa Criscione-Schreiber, and Kathleen A. Cooney. “"Sheroes": Celebrating Women in Medicine Month During the Time of COVID-19.” Acad Med 96, no. 5 (May 1, 2021): e17–18. https://doi.org/10.1097/ACM.0000000000003967.

PMID
33538481
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Schaid, Daniel J., Shannon K. McDonnell, Liesel M. FitzGerald, Lissa DeRycke, Zachary Fogarty, Graham G. Giles, Robert J. MacInnis, et al. “Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.” Eur Urol 79, no. 3 (March 2021): 353–61. https://doi.org/10.1016/j.eururo.2020.07.038.

PMID
32800727
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Shi, Zhuqing, Elizabeth A. Platz, Jun Wei, Rong Na, Richard J. Fantus, Chi-Hsiung Wang, Scott E. Eggener, et al. “Performance of Three Inherited Risk Measures for Predicting Prostate Cancer Incidence and Mortality: A Population-based Prospective Analysis.” Eur Urol 79, no. 3 (March 2021): 419–26. https://doi.org/10.1016/j.eururo.2020.11.014.

PMID
33257031
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Darst, Burcu F., Peggy Wan, Xin Sheng, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, et al. “A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry.” Eur Urol 78, no. 3 (September 2020): 316–20. https://doi.org/10.1016/j.eururo.2020.04.060.

PMID
32409115
Full Text

Pages