Keith Michael Sullivan, MD

Professor of Medicine
James B. Wyngaarden Professor of Medicine, in the School of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Duke Univ Med Ctr, Durham, NC 27710
Phone (919) 664-1762
Email address sulli025@mc.duke.edu

Research areas

  • Late effects of cancer treatment and stem cell transplantation 
  • Chronic graft-versus-host disease 
  • Transplantation for sickle cell and autoimmune diseases 
  • Knowledge engineering

Overview
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.

The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.

Recent preclinical and clinical data suggest that high-dose immunosupression and SCT can halt the progression and, in some settings, reverse the course of autoimmune diseases. Since his arrival at Duke University, over 30 centers nationwide are participating in Duke-led phase II and III trials to test the toxicity, efficacy, and quality of life following autologous and allogeneic stem cell transplantation for autoimmune diseases.

These trials will also serve as platforms to study the immune repertoire and mechanistic pathways before and after SCT to gain greater insight into the basic mechanisms of autoimmunity.

A national repository of tissue and cell specimens is also part of these NIH-supported trials to further promote scientific study from these unique patients.

In Their Words

Education and Training

  • M.D., Indiana University at Indianapolis, 1971

Publications

Somers, TJ, Kelleher, SA, Dorfman, CS, Shelby, RA, Fisher, HM, Rowe Nichols, K, Sullivan, KM, Chao, NJ, Samsa, GP, Abernethy, AP, and Keefe, FJ. "An mHealth Pain Coping Skills Training Intervention for Hematopoietic Stem Cell Transplantation Patients: Development and Pilot Randomized Controlled Trial." JMIR mHealth and uHealth 6, no. 3 (March 19, 2018): e66-.

PMID
29555620
Full Text

Sullivan, KM, Goldmuntz, EA, and Furst, DE. "Autologous Stem-Cell Transplantation for Severe Scleroderma." The New England journal of medicine 378, no. 11 (March 2018): 1066-1067. (Letter)

PMID
29539292
Full Text

Sullivan, KM, Goldmuntz, EA, Keyes-Elstein, L, McSweeney, PA, Pinckney, A, Welch, B, Mayes, MD, Nash, RA, Crofford, LJ, Eggleston, B, Castina, S, Griffith, LM, Goldstein, JS, Wallace, D, Craciunescu, O, Khanna, D, Folz, RJ, Goldin, J, St Clair, EW, Seibold, JR, Phillips, K, Mineishi, S, Simms, RW, Ballen, K, Wener, MH, Georges, GE, Heimfeld, S, Hosing, C, Forman, S, Kafaja, S, Silver, RM, Griffing, L, Storek, J, LeClercq, S, Brasington, R, Csuka, ME, Bredeson, C, Keever-Taylor, C, and Domsic, RT et al. "Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma." The New England journal of medicine 378, no. 1 (January 2018): 35-47.

PMID
29298160
Full Text

Sivaraj, D, Bacon, W, Long, GD, Rizzieri, DA, Horwitz, ME, Sullivan, KM, Kang, Y, Li, Z, Chao, NJ, and Gasparetto, C. "High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma." Bone marrow transplantation 53, no. 1 (January 2018): 34-38.

PMID
29084203
Full Text

Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (December 12, 2017).

PMID
29246821
Full Text

Huang, L-W, Bacon, W, Cirrincione, C, Peterson, B, Long, G, Rizzieri, D, Sullivan, KM, Corbet, K, Horwitz, M, Chao, N, Gasparetto, C, and Tuchman, SA. "Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma." Hematological oncology 35, no. 4 (December 2017): 752-759.

PMID
28105753
Full Text

Arnold, SD, Brazauskas, R, He, N, Li, Y, Aplenc, R, Jin, Z, Hall, M, Atsuta, Y, Dalal, J, Hahn, T, Khera, N, Bonfim, C, Majhail, NS, Diaz, MA, Freytes, CO, Wood, WA, Savani, BN, Kamble, RT, Parsons, S, Ahmed, I, Sullivan, K, Beattie, S, Dandoy, C, Munker, R, Marino, S, Bitan, M, Abdel-Azim, H, Aljurf, M, Olsson, RF, Joshi, S, Buchbinder, D, Eckrich, MJ, Hashmi, S, Lazarus, H, Marks, DI, Steinberg, A, Saad, A, Gergis, U, Krishnamurti, L, Abraham, A, Rangarajan, HG, Walters, M, and Lipscomb, J et al. "Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases." Haematologica 102, no. 11 (November 2017): 1823-1832.

PMID
28818869
Full Text

Keever-Taylor, CA, Heimfeld, S, Steinmiller, KC, Nash, RA, Sullivan, KM, Czarniecki, CW, Granderson, TC, Goldstein, JS, and Griffith, LM. "Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 9 (September 2017): 1463-1472.

PMID
28602891
Full Text

Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157.

PMID
28392378
Full Text

Sivaraj, D, Green, MM, Li, Z, Sung, AD, Sarantopoulos, S, Kang, Y, Long, GD, Horwitz, ME, Lopez, RD, Sullivan, KM, Rizzieri, DA, Chao, NJ, and Gasparetto, C. "Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 2 (February 2017): 262-268.

PMID
27856369
Full Text

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