Keith Michael Sullivan, MD

Professor of Medicine
James B. Wyngaarden Professor of Medicine, in the School of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address sulli025@mc.duke.edu

Research areas

  • Late effects of cancer treatment and stem cell transplantation 
  • Chronic graft-versus-host disease 
  • Transplantation for sickle cell and autoimmune diseases 
  • Knowledge engineering

Overview
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.

The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.

Recent preclinical and clinical data suggest that high-dose immunosupression and SCT can halt the progression and, in some settings, reverse the course of autoimmune diseases. Since his arrival at Duke University, over 30 centers nationwide are participating in Duke-led phase II and III trials to test the toxicity, efficacy, and quality of life following autologous and allogeneic stem cell transplantation for autoimmune diseases.

These trials will also serve as platforms to study the immune repertoire and mechanistic pathways before and after SCT to gain greater insight into the basic mechanisms of autoimmunity.

A national repository of tissue and cell specimens is also part of these NIH-supported trials to further promote scientific study from these unique patients.

In Their Words

Education and Training

  • M.D., Indiana University at Indianapolis, 1971

Publications

Rizzieri, David A., Liang Piu Koh, Gwynn D. Long, Cristina Gasparetto, Keith M. Sullivan, Mitchell Horwitz, John Chute, et al. “Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution..” J Clin Oncol 25, no. 6 (February 20, 2007): 690–97. https://doi.org/10.1200/JCO.2006.07.0953.

PMID
17228020
Full Text

Eggleston, B., M. Patience, S. Edwards, T. Adamkiewicz, G. R. Buchanan, S. C. Davies, R. Dickerhoff, et al. “Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia..” Br J Haematol 136, no. 4 (February 2007): 673–76. https://doi.org/10.1111/j.1365-2141.2006.06486.x.

PMID
17223910
Full Text

Craciunescu, O., B. Steffey, S. Yoo, N. Larrier, C. Paarz‐largay, K. Sullivan, and R. Prosnitz. “TU‐EE‐A2‐05: Challenges in Limiting Kidney Dose When Delivering Total Body Irradiation (TBI) for Patients with Severe Systemic Sclerosis (SSc).” In Medical Physics, Vol. 34, 2007. https://doi.org/10.1118/1.2761426.

Full Text

Storek, Jan, Richard A. Nash, Peter A. McSweeney, Daniel E. Furst, and Keith M. Sullivan. “Normal interleukin-7 (IL7) levels and normal IL7 response to CD4 T lymphopenia in patients with multiple sclerosis and systemic sclerosis..” Clin Immunol 121, no. 1 (October 2006): 118–19. https://doi.org/10.1016/j.clim.2006.05.016.

PMID
16844418
Full Text

Sullivan, Keith M., Peter A. McSweeney, and Richard A. Nash. “Cyclophosphamide in scleroderma lung disease..” N Engl J Med 355, no. 11 (September 14, 2006): 1173–74.

PMID
16977701
Scholars@Duke

Nash, Richard A., Peter A. McSweeney, Leslie J. Crofford, Kevin T. McDonagh, Keith M. Sullivan, Mayes Maureen, J Lee Nelson, et al. “5-year follow-up of high-dose immunosuppressive therapy (HDIT) for systemic sclerosis (SSc)..” In Arthritis and Rheumatism, 54:S315–S315. WILEY-LISS, 2006.

Scholars@Duke

Nash, Richard A., Peter A. McSweeney, J Lee Nelson, Mark Wener, George E. Georges, Amelia A. Langston, Howard Shulman, et al. “Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis..” Arthritis Rheum 54, no. 6 (June 2006): 1982–86. https://doi.org/10.1002/art.21908.

PMID
16732546
Full Text

Rizzieri, D. A., L. P. Koh, G. D. Long, C. Gasparetto, K. M. Sullivan, M. Horwitz, J. Chute, et al. “Partially HLA matched, non-myeloablative allogeneic transplantation.” In Blood, 106:812A-812A. AMER SOC HEMATOLOGY, 2005.

Scholars@Duke

Rizzieri, D. A., L. P. Koh, G. D. Long, C. Gasparetto, J. Z. Gong, A. S. Lagoo, D. Niedzwiecki, et al. “Outcome and immune reconstitution following T cell depleted nonmyeloablative allogeneic transplantation using matched donors.” In Blood, 106:576A-576A. AMER SOC HEMATOLOGY, 2005.

Scholars@Duke

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