Keith Michael Sullivan, MD

Professor of Medicine
James B. Wyngaarden Professor of Medicine, in the School of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address sulli025@mc.duke.edu

Research areas

  • Late effects of cancer treatment and stem cell transplantation 
  • Chronic graft-versus-host disease 
  • Transplantation for sickle cell and autoimmune diseases 
  • Knowledge engineering

Overview
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.

The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.

Recent preclinical and clinical data suggest that high-dose immunosupression and SCT can halt the progression and, in some settings, reverse the course of autoimmune diseases. Since his arrival at Duke University, over 30 centers nationwide are participating in Duke-led phase II and III trials to test the toxicity, efficacy, and quality of life following autologous and allogeneic stem cell transplantation for autoimmune diseases.

These trials will also serve as platforms to study the immune repertoire and mechanistic pathways before and after SCT to gain greater insight into the basic mechanisms of autoimmunity.

A national repository of tissue and cell specimens is also part of these NIH-supported trials to further promote scientific study from these unique patients.

In Their Words

Education and Training

  • M.D., Indiana University at Indianapolis, 1971

Publications

Furst, D. E., P. A. McSweeney, L. J. Crofford, K. T. McDonagh, K. M. Sullivan, M. D. Mayes, J. L. Nelson, et al. “High-Dose Immunosuppressive Therapy (HDIT) for SSc: Results of 3 year follow-up demonstrate continued improvement in function and skin with stability in the lungs.” In Arthritis and Rheumatism, 50:S693–S693. WILEY-LISS, 2004.

Scholars@Duke

Chao, Nelson J., Liang-Piu Koh, Gwynn D. Long, Cristina Gasparetto, Mitchell Horwitz, Ashley Morris, Martha Lassiter, Keith M. Sullivan, and David A. Rizzieri. “Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens..” Biol Blood Marrow Transplant 10, no. 8 (August 2004): 569–75. https://doi.org/10.1016/j.bbmt.2004.05.001.

PMID
15282535
Full Text

Nishimura, Jun-Ichi, Yuzuru Kanakura, Russell E. Ware, Tsutomu Shichishima, Hideki Nakakuma, Haruhiko Ninomiya, Carlos M. Decastro, et al. “Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan..” Medicine (Baltimore) 83, no. 3 (May 2004): 193–207. https://doi.org/10.1097/01.md.0000126763.68170.46.

PMID
15118546
Full Text

Bichindaritz, I., C. Moinpour, E. Kansu, G. Donaldson, N. Bush, and K. M. Sullivan. “Case based reasoning for medical decision-support in a safety critical environment.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2780 LNAI (December 1, 2003): 314–23. https://doi.org/10.1007/978-3-540-39907-0_43.

Full Text

Woodard, J. P., J. M. Cunningham, K. M. Sullivan, N. R. Kamani, and M. C. Walters. “Bronchiolitis obliterans organizing pneumonia (BOOP) after bone marrow transplantation (BMT) for sickle cell disease (SCD): Association with acute chest syndrome (ACS)..” In Blood, 102:460B-461B. AMER SOC HEMATOLOGY, 2003.

Scholars@Duke

Nash, Richard A., James D. Bowen, Peter A. McSweeney, Steven Z. Pavletic, Kenneth R. Maravilla, Man-soo Park, Jan Storek, et al. “High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis..” Blood 102, no. 7 (October 1, 2003): 2364–72. https://doi.org/10.1182/blood-2002-12-3908.

PMID
12763935
Full Text

Adamkiewicz, Thomas V., Sharada Sarnaik, George R. Buchanan, Rathi V. Iyer, Scott T. Miller, Charles H. Pegelow, Zora R. Rogers, et al. “Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination..” J Pediatr 143, no. 4 (October 2003): 438–44. https://doi.org/10.1067/S0022-3476(03)00331-7.

PMID
14571216
Full Text

Nash, Richard A., Roger Dansey, Jan Storek, George E. Georges, James D. Bowen, Leona A. Holmberg, George H. Kraft, et al. “Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder after high-dose immunosuppressive therapy and autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases..” Biol Blood Marrow Transplant 9, no. 9 (September 2003): 583–91.

PMID
14506660
Scholars@Duke

Chen, Chien-Shing, M. Boeckh, K. Seidel, J. G. Clark, E. Kansu, D. K. Madtes, J. L. Wagner, et al. “Incidence, risk factors, and mortality from pneumonia developing late after hematopoietic stem cell transplantation..” Bone Marrow Transplant 32, no. 5 (September 2003): 515–22. https://doi.org/10.1038/sj.bmt.1704162.

PMID
12942099
Full Text

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