Kevin J Wiehe, PhD

Publications

Roark, Ryan S., Hui Li, Wilton B. Williams, Hema Chug, Rosemarie D. Mason, Jason Gorman, Shuyi Wang, et al. “Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.” Science 371, no. 6525 (January 8, 2021). https://doi.org/10.1126/science.abd2638.

PMID
33214287
Full Text

McNamara, Hayley A., Azza H. Idris, Henry J. Sutton, Rachel Vistein, Barbara J. Flynn, Yeping Cai, Kevin Wiehe, et al. “Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response.” Cell Host Microbe 28, no. 4 (October 7, 2020): 572-585.e7. https://doi.org/10.1016/j.chom.2020.07.001.

PMID
32697938
Full Text

Sempowski, Gregory D., Kevin O. Saunders, Priyamvada Acharya, Kevin J. Wiehe, and Barton F. Haynes. “Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.” Cell 181, no. 7 (June 25, 2020): 1458–63. https://doi.org/10.1016/j.cell.2020.05.041.

PMID
32492407
Full Text

Martinez, David R., Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, et al. “Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.” Mbio 11, no. 2 (March 10, 2020). https://doi.org/10.1128/mBio.00176-20.

PMID
32156815
Full Text

Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.

PMID
32075963
Full Text

Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.

PMID
31806786
Full Text

LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 12 (December 2019): e1008200. https://doi.org/10.1371/journal.ppat.1008200.

PMID
31790514
Full Text

LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 9 (September 2019): e1008026. https://doi.org/10.1371/journal.ppat.1008026.

PMID
31527908
Full Text

Sacks, David, Jinal N. Bhiman, Kevin Wiehe, Jason Gorman, Peter D. Kwong, Lynn Morris, and Penny L. Moore. “Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.” Plos Pathog 15, no. 9 (September 2019): e1008005. https://doi.org/10.1371/journal.ppat.1008005.

PMID
31479499
Full Text

Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.” Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.

PMID
31308388
Full Text

Pages