Kevin J Wiehe, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 106 Research Dr, MSRBII Box 103020, Durham, NC 27710
Phone (919) 684-2320

Education and Training

  • Ph.D., Boston University, 2007

Publications

Henderson, Rory, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, et al. “Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies..” Nature Communications 10, no. 1 (February 8, 2019). https://doi.org/10.1038/s41467-019-08415-7.

PMID
30737386
Full Text

Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite..” Nature Medicine 25, no. 1 (January 2019): 188–89. https://doi.org/10.1038/s41591-018-0315-0.

PMID
30552419
Full Text

Bonsignori, Mattia, Eric Scott, Kevin Wiehe, David Easterhoff, S Munir Alam, Kwan-Ki Hwang, Melissa Cooper, et al. “Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier..” Immunity 49, no. 6 (December 11, 2018): 1162-1174.e8. https://doi.org/10.1016/j.immuni.2018.10.015.

PMID
30552024
Full Text

Eeden, Charmaine van, Constantinos Kurt Wibmer, Cathrine Scheepers, Simone I. Richardson, Molati Nonyane, Bronwen Lambson, Nonhlanhla N. Mkhize, et al. “V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity..” Cell Reports 25, no. 11 (December 2018): 3123-3135.e6. https://doi.org/10.1016/j.celrep.2018.11.058.

PMID
30540944
Full Text

Wiehe, Kevin, Todd Bradley, R Ryan Meyerhoff, Connor Hart, Wilton B. Williams, David Easterhoff, William J. Faison, et al. “Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development..” Cell Host & Microbe 23, no. 6 (June 2018): 759-765.e6. https://doi.org/10.1016/j.chom.2018.04.018.

PMID
29861171
Full Text

Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite..” Nat Med 24, no. 4 (May 2018): 408–16. https://doi.org/10.1038/nm.4512.

PMID
29554083
Full Text

Fera, Daniela, Matthew S. Lee, Kevin Wiehe, R Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, et al. “HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope..” Nature Communications 9, no. 1 (March 16, 2018). https://doi.org/10.1038/s41467-018-03565-6.

PMID
29549260
Full Text

Williams, Wilton B., Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M Anthony Moody, et al. “Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations..” Nature Communications 8, no. 1 (November 23, 2017). https://doi.org/10.1038/s41467-017-01336-3.

PMID
29170366
Full Text

Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques..” Journal of Virology 91, no. 21 (November 2017). https://doi.org/10.1128/JVI.00923-17.

PMID
28794027
Full Text

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