Kevin J Wiehe, PhD

Publications

Martinez, David R., Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, et al. “Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.” Mbio 11, no. 2 (March 10, 2020). https://doi.org/10.1128/mBio.00176-20.

PMID
32156815
Full Text

Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.

PMID
32075963
Full Text

Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.

PMID
31806786
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LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 12 (December 2019): e1008200. https://doi.org/10.1371/journal.ppat.1008200.

PMID
31790514
Full Text

LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 9 (September 2019): e1008026. https://doi.org/10.1371/journal.ppat.1008026.

PMID
31527908
Full Text

Sacks, David, Jinal N. Bhiman, Kevin Wiehe, Jason Gorman, Peter D. Kwong, Lynn Morris, and Penny L. Moore. “Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.” Plos Pathog 15, no. 9 (September 2019): e1008005. https://doi.org/10.1371/journal.ppat.1008005.

PMID
31479499
Full Text

Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.” Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.

PMID
31308388
Full Text

Henderson, Rory, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, et al. “Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies.” Nat Commun 10, no. 1 (February 8, 2019): 654. https://doi.org/10.1038/s41467-019-08415-7.

PMID
30737386
Full Text

Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.” Nat Med 25, no. 1 (January 2019): 188–89. https://doi.org/10.1038/s41591-018-0315-0.

PMID
30552419
Full Text

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