Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Lee, Chang-Lung, Jessica W. Lee, Andrea R. Daniel, Matt Holbrook, Stephanie Hasapis, Ato O. Wright, Jeremy Brownstein, et al. “Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.” Radiother Oncol 157 (April 2021): 155–62. https://doi.org/10.1016/j.radonc.2021.01.023.

PMID
33545252
Full Text

Kim, Jihee, Chad A. Grotegut, James W. Wisler, Lan Mao, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.” Proc Natl Acad Sci U S A 117, no. 22 (June 2, 2020): 12435–43. https://doi.org/10.1073/pnas.1920310117.

PMID
32414934
Full Text

Nielsen, Natalie R., Krsna V. Rangarajan, Lan Mao, Howard A. Rockman, and Kathleen M. Caron. “A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis.” Am J Physiol Heart Circ Physiol 318, no. 4 (April 1, 2020): H895–907. https://doi.org/10.1152/ajpheart.00436.2019.

PMID
32142379
Full Text

Yu, Yen-Rei A., Yuryi Malakhau, Chen-Hsin A. Yu, Stefan-Laural J. Phelan, R Ian Cumming, Matthew J. Kan, Lan Mao, Sudarshan Rajagopal, Claude A. Piantadosi, and Michael D. Gunn. “Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension.” J Immunol 204, no. 6 (March 15, 2020): 1474–85. https://doi.org/10.4049/jimmunol.1900239.

PMID
31996456
Full Text

Yu, Samuel Mon-Wei, Pierre-Yves Jean-Charles, Dennis M. Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A. Rockman, and Sudha K. Shenoy. “The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.” J Biol Chem 294, no. 7 (February 15, 2019): 2500–2518. https://doi.org/10.1074/jbc.RA118.004926.

PMID
30538132
Full Text

Dai, Qunsheng, Creighton E. Likes, Anthony L. Luz, Lan Mao, Jason S. Yeh, Zhengzheng Wei, Maragatha Kuchibhatla, Olga R. Ilkayeva, Timothy R. Koves, and Thomas M. Price. “A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.” J Endocr Soc 3, no. 2 (February 1, 2019): 446–67. https://doi.org/10.1210/js.2018-00219.

PMID
30746505
Full Text

Kim, Jihee, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.” Skelet Muscle 8, no. 1 (December 27, 2018): 39. https://doi.org/10.1186/s13395-018-0184-8.

PMID
30591079
Full Text

Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.” J Clin Invest 128, no. 11 (November 1, 2018): 4843–55. https://doi.org/10.1172/JCI95945.

PMID
30153110
Full Text

Toth, Krisztian, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter Boone, Lan Mao, Dennis Abraham, Marc G. Caron, and Lawrence S. Barak. “Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.” Synapse 72, no. 1 (January 2018). https://doi.org/10.1002/syn.22012.

PMID
28941296
Full Text

Pages