Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Wisler, JW, Harris, EM, Raisch, M, Mao, L, Kim, J, Rockman, HA, and Lefkowitz, RJ. "The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome." American journal of physiology. Heart and circulatory physiology 309, no. 9 (November 2015): H1516-H1527.

PMID
26371162
Full Text

Xu, W, Barrientos, T, Mao, L, Rockman, HA, Sauve, AA, and Andrews, NC. "Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart." Cell reports 13, no. 3 (October 7, 2015): 533-545.

PMID
26456827
Full Text

Abraham, D, and Mao, L. "Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice." Journal of visualized experiments : JoVE, no. 103 (September 17, 2015).

PMID
26436838
Full Text

Pironti, G, Strachan, RT, Abraham, D, Mon-Wei Yu, S, Chen, M, Chen, W, Hanada, K, Mao, L, Watson, LJ, and Rockman, HA. "Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors." Circulation 131, no. 24 (June 2015): 2120-2130.

PMID
25995315
Full Text

Moding, EJ, Lee, C-L, Castle, KD, Oh, P, Mao, L, Zha, S, Min, HD, Ma, Y, Das, S, and Kirsch, DG. "Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium." The Journal of clinical investigation 124, no. 8 (August 2014): 3325-3338.

PMID
25036710
Full Text

Ashton, JR, Befera, N, Clark, D, Qi, Y, Mao, L, Rockman, HA, Johnson, GA, and Badea, CT. "Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent." Contrast media & molecular imaging 9, no. 2 (March 2014): 161-168.

PMID
24523061
Full Text

Kim, I-M, Wang, Y, Park, K-M, Tang, Y, Teoh, J-P, Vinson, J, Traynham, CJ, Pironti, G, Mao, L, Su, H, Johnson, JA, Koch, WJ, and Rockman, HA. "β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing." Circ Res 114, no. 5 (February 28, 2014): 833-844.

PMID
24334028
Full Text

Kim, IM, Wang, Y, Park, KM, Tang, Y, Teoh, JP, Vinson, J, Traynham, CJ, Pironti, G, Mao, L, Su, H, Johnson, JA, Koch, WJ, and Rockman, HA. "β-arrestin1-biased β1-adrenergic receptor signaling regulates MicroRNA processing." Circulation Research 114, no. 5 (February 28, 2014): 833-844.

Full Text

Santacruz, L, Hernandez, A, Nienaber, J, Mishra, R, Pinilla, M, Burchette, J, Mao, L, Rockman, HA, and Jacobs, DO. "Normal cardiac function in mice with supraphysiological cardiac creatine levels." Am J Physiol Heart Circ Physiol 306, no. 3 (February 2014): H373-H381.

PMID
24271489
Full Text

Yu, Y-RA, Mao, L, Piantadosi, CA, and Gunn, MD. "CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension." Am J Respir Cell Mol Biol 48, no. 5 (May 2013): 647-654.

PMID
23492191
Full Text

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