Li-Tzy Wu, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Campus mail Duke Psychiatry, DUMC Box # 11, Durham, NC 27710
Phone (919) 889-9369
Email address

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.
Research interests: COVID-19, Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator [PI], Site PI, or Sub-award PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA, PI).
UG1: NIDA CTN Mid-Southern Node (Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Site PI).
CDC R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward PI, Investigator).
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (NIDA supplement, CTN-0101, Investigator).
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI).
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, NIDA, PI).
UG1: NorthStar Node of the Clinical Trials Network (NIDA, Site PI).
R34: Intervention Development and Pilot Study to Reduce Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders (Subaward PI, Investigator).
UG1: Optimal Policies to Improve Methadone Maintenance Adherence Longterm (OPTIMMAL Study) (NIDA, Site PI).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York, New Paltz, 1992


Joudrey, Paul J., Gavin Bart, Robert K. Brooner, Lawrence Brown, Julie Dickson-Gomez, Adam Gordon, Sarah S. Kawasaki, et al. “Research priorities for expanding access to methadone treatment for opioid use disorder in the United States: A National Institute on Drug Abuse Center for Clinical Trials Network Task Force report.” Subst Abus 42, no. 3 (2021): 245–54.

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Zhu, He, and Li-Tzy Wu. “Multiple drug use disorder diagnoses among drug-involved hospitalizations in the United States: Results from the 2016 National Inpatient Sample.” Drug Alcohol Depend 213 (June 12, 2020): 108113.

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Carmona, Jasmin, Jane Carlisle Maxwell, Ji-Yeun Park, and Li-Tzy Wu. “Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents.” J Adolesc Health 66, no. 5 (May 2020): 536–44.

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John, William S., and Li-Tzy Wu. “Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization.” Drug Alcohol Depend 209 (April 1, 2020): 107902.

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Nordeck, Courtney D., Jan Gryczynski, Kevin E. O’Grady, Kathryn Polak, Dace S. Svikis, Jennifer McNeely, Li-Tzy Wu, and Robert P. Schwartz. “Comparison of timeline follow-back self-report and oral fluid testing to detect substance use in adult primary care patients.” Drug Alcohol Depend 209 (April 1, 2020): 107939.

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Wu, Li-Tzy, Elizabeth H. Payne, Kimberly Roseman, Ashley Case, Casey Nelson, and Robert Lindblad. “Using a health information technology survey to explore the availability of addiction treatment data in the electronic health records: A National Drug Abuse Treatment Clinical Trials Network study.” J Subst Abuse Treat 112S (March 2020): 56–62.

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Subica, Andrew M., Erick Guerrero, Nia Aitaoto, Howard B. Moss, Derek Iwamoto, and Li-Tzy Wu. “Hazardous drinking, alcohol use disorders, and need for treatment among Pacific Islander young adults.” Am J Orthopsychiatry 90, no. 5 (2020): 557–66.

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John, William S., Kiran Grover, Lawrence H. Greenblatt, Robert P. Schwartz, and Li-Tzy Wu. “E-Cigarette Use Among Adult Primary Care Patients: Results from a Multisite Study.” J Gen Intern Med 35, no. 1 (January 2020): 268–75.

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Park, Ji-Yeun, and Li-Tzy Wu. “Sources of Misused Prescription Opioids and Their Association with Prescription Opioid Use Disorder in the United States: Sex and Age Differences.” Subst Use Misuse 55, no. 6 (2020): 928–36.

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