Li-Tzy Wu, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Campus mail Duke Psychiatry, DUMC Box # 11, Durham, NC 27710
Phone (919) 889-9369
Email address

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.
Research interests: COVID-19, Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator [PI], Site PI, or Sub-award PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA, PI).
UG1: NIDA CTN Mid-Southern Node (Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Site PI).
CDC R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward PI, Investigator).
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (NIDA supplement, CTN-0101, Investigator).
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI).
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, NIDA, PI).
UG1: NorthStar Node of the Clinical Trials Network (NIDA, Site PI).
R34: Intervention Development and Pilot Study to Reduce Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders (Subaward PI, Investigator).
UG1: Optimal Policies to Improve Methadone Maintenance Adherence Longterm (OPTIMMAL Study) (NIDA, Site PI).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York, New Paltz, 1992


Wechsberg, W. M., L. T. Wu, W. A. Zule, C. D. Parry, F. A. Browne, W. K. Luseno, T. Kline, and A. Gentry. “Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa.” In Social Work in Mental Health and Substance Abuse, 77–93, 2016.


Cottler, Linda B., Hui Hu, Bryan A. Smallwood, James C. Anthony, Li-Tzy Wu, and William W. Eaton. “Nonmedical Opioid Pain Relievers and All-Cause Mortality: A 27-Year Follow-Up From the Epidemiologic Catchment Area Study.” Am J Public Health 106, no. 3 (March 2016): 509–16.

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Li, Linlin, Adriana Pérez, Li-Tzy Wu, Nalini Ranjit, Henry S. Brown, and Steven H. Kelder. “Cardiometabolic Risk Factors among Severely Obese Children and Adolescents in the United States, 1999-2012.” Child Obes 12, no. 1 (February 2016): 12–19.

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Wu, Li-Tzy, Kathleen T. Brady, Susan E. Spratt, Ashley A. Dunham, Brooke Heidenfelder, Bryan C. Batch, Robert Lindblad, et al. “Using electronic health record data for substance use Screening, Brief Intervention, and Referral to Treatment among adults with type 2 diabetes: Design of a National Drug Abuse Treatment Clinical Trials Network study.” Contemp Clin Trials 46 (January 2016): 30–38.

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Gryczynski, Jan, Courtney Nordeck, Shannon Gwin Mitchell, Kevin E. O’Grady, Jennifer McNeely, Li-Tzy Wu, and Robert P. Schwartz. “Reference periods in retrospective behavioral self-report: A qualitative investigation.” Am J Addict 24, no. 8 (December 2015): 744–47.

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Wu, Li-Tzy, Udi E. Ghitza, Bryan C. Batch, Michael J. Pencina, Leoncio Flavio Rojas, Benjamin A. Goldstein, Tony Schibler, Ashley A. Dunham, Shelley Rusincovitch, and Kathleen T. Brady. “Substance use and mental diagnoses among adults with and without type 2 diabetes: Results from electronic health records data.” Drug Alcohol Depend 156 (November 1, 2015): 162–69.

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Lopez-Quintero, Catalina, Kimberly B. Roth, William W. Eaton, Li-Tzy Wu, Linda B. Cottler, Martha Bruce, and James C. Anthony. “Mortality among heroin users and users of other internationally regulated drugs: A 27-year follow-up of users in the Epidemiologic Catchment Area Program household samples.” Drug Alcohol Depend 156 (November 1, 2015): 104–11.

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