Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989



Liu, L., A. Hausladen, M. Zeng, L. Que, J. Heitman, and J. S. Stamler. “A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.” Nature 410, no. 6827 (March 22, 2001): 490–94. https://doi.org/10.1038/35068596.

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Liu, L., A. Hausladen, M. Zeng, L. Que, J. Heitman, J. S. Stamler, and D. Steverding. “Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase.” Redox Rep 6, no. 4 (2001): 209–10. https://doi.org/10.1179/135100001101536337.

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Lau, C. L., R. C. Bentley, J. P. Gockerman, L. G. Que, and T. A. D’Amico. “Malignant melanoma presenting as a mediastinal mass.” Ann Thorac Surg 67, no. 3 (March 1999): 851–52. https://doi.org/10.1016/s0003-4975(99)00075-2.

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Que, L. G., S. P. Kantrow, C. P. Jenkinson, C. A. Piantadosi, and Y. C. T. Huang. “Induction of arginase isoforms in the lung during hyperoxia.” American Journal of Physiology Lung Cellular and Molecular Physiology 275, no. 1 (July 1, 1998): L96–102.


Que, L. G., B. H. Kang, Y. C. Huang, C. A. Piantadosi, and L. Y. Chang. “Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis.” Shock 9, no. 4 (April 1998): 304–9. https://doi.org/10.1097/00024382-199804000-00011.

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Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.

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