Lori Ann Orlando, MD

Associate Professor of Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS is an Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Mecicine, Tulane University, 1998 - 2001
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Vorderstrasse, Allison A., Alex Cho, Corrine I. Voils, Lori A. Orlando, and Geoffrey S. Ginsburg. “Clinical utility of genetic risk testing in primary care: the example of Type 2 diabetes..” Personalized Medicine 10, no. 6 (August 2013): 549–63. https://doi.org/10.2217/pme.13.47.

PMID
29776196
Full Text

Powell, Karen P., Carol A. Christianson, Susan E. Hahn, Gaurav Dave, Leslie R. Evans, Susan H. Blanton, Elizabeth Hauser, et al. “Collection of family health history for assessment of chronic disease risk in primary care..” North Carolina Medical Journal 74, no. 4 (July 2013): 279–86.

PMID
24044144
Scholars@Duke

Orlando, Lori A., Adam H. Buchanan, Susan E. Hahn, Carol A. Christianson, Karen P. Powell, Celette Sugg Skinner, Blair Chesnut, et al. “Development and validation of a primary care-based family health history and decision support program (MeTree)..” N C Med J 74, no. 4 (July 2013): 287–96.

PMID
24044145
Scholars@Duke

Wu, Rebekah R., Tiffany Himmel, Adam Buchanan, Karen Powell, Elizabeth Hauser, Astrid B. Agbaje, Geoffrey S. Ginsburg, Vincent Henrich, and Lori A. Orlando. “IMPACT OF A FAMILY HISTORY COLLECTION TOOL, METREE (c), IN IDENTIFYING INDIVIDUALS AT HIGH-RISK FOR CANCER AND THROMBOSIS.” In Journal of General Internal Medicine, 28:S101–S101. SPRINGER, 2013.

Scholars@Duke

Wu, Rebekah R., Tiffany Himmel, Karen Powell, Elizabeth Hauser, Astrid B. Agbaje, Vincent Henrich, Geoffrey S. Ginsburg, and Lori A. Orlando. “USABILITY OF A FAMILY HEALTH HISTORY AND CLINICAL DECISION SUPPORT TOOL FOR PATIENTS AND PRIMARY CARE PROVIDERS.” In Journal of General Internal Medicine, 28:S233–S233. SPRINGER, 2013.

Scholars@Duke

Orlando, Lori A., Vincent C. Henrich, Elizabeth R. Hauser, Charles Wilson, Geoffrey S. Ginsburg, and Geoffrey S. Genomedical Connection. “The genomic medicine model: an integrated approach to implementation of family health history in primary care..” Personalized Medicine 10, no. 3 (May 2013): 295–306. https://doi.org/10.2217/pme.13.20.

PMID
29768748
Full Text

Orlando, L. A., and A. H. cho. “Clinical Implementation of Genomic Medicine in Primary Care.” In Genomic and Personalized Medicine, edited by G. S. ginsburg and H. willard. San Diego, CA: Academic Press, 2012.

Scholars@Duke

Orlando, Lori A., Elizabeth R. Hauser, Carol Christianson, Karen P. Powell, Adam H. Buchanan, Blair Chesnut, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey Ginsburg. “Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system..” Bmc Health Serv Res 11 (October 11, 2011). https://doi.org/10.1186/1472-6963-11-264.

PMID
21989281
Full Text

Haga, Susanne B., Madeline M. Carrig, Julianne M. O’Daniel, Lori A. Orlando, Ley A. Killeya-Jones, Geoffrey S. Ginsburg, and Alex Cho. “Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling..” J Gen Intern Med 26, no. 8 (August 2011): 834–40. https://doi.org/10.1007/s11606-011-1651-7.

PMID
21311998
Full Text

Orlando, Lori A., Elizabeth R. Hauser, Carol Christianson, Karen P. Powell, Adam H. Buchanan, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey Ginsburg. “WHAT'S THE IMPACT? CLINICAL VALIDITY AND UTILITY OF METREE, AN ELECTRONIC FAMILY HISTORY COLLECTION AND DECISION SUPPORT TOOL FOR PRIMARY CARE.” Journal of General Internal Medicine 26 (May 1, 2011): S35–36.

Scholars@Duke

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