Lori Ann Orlando, MD

Associate Professor of Medicine
Associate Director of Duke Center for Applied Genomics and Precision Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS is an Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Mecicine, Tulane University, 1998 - 2001
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Orlando, Lori A., Elizabeth R. Hauser, Carol Christianson, Karen P. Powell, Adam H. Buchanan, Blair Chesnut, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey Ginsburg. “Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system..” Bmc Health Serv Res 11 (October 11, 2011). https://doi.org/10.1186/1472-6963-11-264.

PMID
21989281
Full Text

Haga, Susanne B., Madeline M. Carrig, Julianne M. O’Daniel, Lori A. Orlando, Ley A. Killeya-Jones, Geoffrey S. Ginsburg, and Alex Cho. “Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling..” J Gen Intern Med 26, no. 8 (August 2011): 834–40. https://doi.org/10.1007/s11606-011-1651-7.

PMID
21311998
Full Text

Orlando, Lori A., Eric J. Belasco, Uptal D. Patel, and David B. Matchar. “The chronic kidney disease model: a general purpose model of disease progression and treatment..” Bmc Med Inform Decis Mak 11 (June 16, 2011). https://doi.org/10.1186/1472-6947-11-41.

PMID
21679455
Full Text

Orlando, Lori A., Elizabeth R. Hauser, Carol Christianson, Karen P. Powell, Adam H. Buchanan, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey Ginsburg. “WHAT'S THE IMPACT? CLINICAL VALIDITY AND UTILITY OF METREE, AN ELECTRONIC FAMILY HISTORY COLLECTION AND DECISION SUPPORT TOOL FOR PRIMARY CARE.” Journal of General Internal Medicine 26 (May 1, 2011): S35–36.

Scholars@Duke

Mather, Richard C., Lori A. Orlando, Robert A. Henderson, J Todd R. Lawrence, and Dean C. Taylor. “A predictive model of shoulder instability after a first-time anterior shoulder dislocation..” J Shoulder Elbow Surg 20, no. 2 (March 2011): 259–66. https://doi.org/10.1016/j.jse.2010.10.037.

PMID
21276928
Full Text

Watters, Tyler Steven, James A. Browne, Lori A. Orlando, Samuel S. Wellman, James R. Urbaniak, and Michael P. Bolognesi. “Cost-effectiveness analysis of free vascularized fibular grafting for osteonecrosis of the femoral head..” J Surg Orthop Adv 20, no. 3 (2011): 158–67.

PMID
22214140
Scholars@Duke

Mather, Richard C., Tyler S. Watters, Lori A. Orlando, Michael P. Bolognesi, and Claude T. Moorman. “Cost effectiveness analysis of hemiarthroplasty and total shoulder arthroplasty..” J Shoulder Elbow Surg 19, no. 3 (April 2010): 325–34. https://doi.org/10.1016/j.jse.2009.11.057.

PMID
20303459
Full Text

Kawamoto, Kensaku, Lori A. Orlando, Deepak Voora, David F. Lobach, Scott Joy, Alex Cho, and Geoffrey S. Ginsburg. “Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays..” Amia Annu Symp Proc 2009 (November 14, 2009): 307–11.

PMID
20351870
Scholars@Duke

Pages