Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Crystal, Ronald G., Scott H. Randell, John F. Engelhardt, Judith Voynow, and Mary E. Sunday. “Airway epithelial cells: current concepts and challenges..” Proc Am Thorac Soc 5, no. 7 (September 15, 2008): 772–77. https://doi.org/10.1513/pats.200805-041HR.

PMID
18757316
Full Text

Franks, Teri J., Thomas V. Colby, William D. Travis, Rubin M. Tuder, Herbert Y. Reynolds, Arnold R. Brody, Wellington V. Cardoso, et al. “Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function..” Proc Am Thorac Soc 5, no. 7 (September 15, 2008): 763–66. https://doi.org/10.1513/pats.200803-025HR.

PMID
18757314
Full Text

Shan, Lin, Meera Subramaniam, Rodica L. Emanuel, Simone Degan, Pamela Johnston, Denise Tefft, David Warburton, and Mary E. Sunday. “Centrifugal migration of mesenchymal cells in embryonic lung..” Dev Dyn 237, no. 3 (March 2008): 750–57. https://doi.org/10.1002/dvdy.21462.

PMID
18297731
Full Text

Haley, Kathleen J., Mary E. Sunday, Yolanda Porrata, Colleen Kelley, Anne Twomey, Aliakbar Shahsafaei, Benjamin Galper, Larry A. Sonna, and Craig M. Lilly. “Ontogeny of the eotaxins in human lung..” Am J Physiol Lung Cell Mol Physiol 294, no. 2 (February 2008): L214–24. https://doi.org/10.1152/ajplung.00086.2007.

PMID
18055844
Full Text

Subramaniam, Meera, Christine Bausch, Anne Twomey, Svetlana Andreeva, Bradley A. Yoder, LingYi Chang, James D. Crapo, Richard A. Pierce, Frank Cuttitta, and Mary E. Sunday. “Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia..” Am J Respir Crit Care Med 176, no. 9 (November 1, 2007): 902–12. https://doi.org/10.1164/rccm.200611-1734OC.

PMID
17585105
Full Text

Levesque, Bernadette M., Shutang Zhou, Lin Shan, Pamela Johnston, Yanping Kong, Simone Degan, and Mary E. Sunday. “NPAS1 regulates branching morphogenesis in embryonic lung..” Am J Respir Cell Mol Biol 36, no. 4 (April 2007): 427–34. https://doi.org/10.1165/rcmb.2006-0314OC.

PMID
17110583
Full Text

Shan, Lin, Jon C. Aster, Jeffrey Sklar, and Mary E. Sunday. “Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice..” Am J Physiol Lung Cell Mol Physiol 292, no. 2 (February 2007): L500–509. https://doi.org/10.1152/ajplung.00052.2006.

PMID
17028268
Full Text

Rosen, Dennis, Jong-Hwan Lee, Frank Cuttitta, Fatema Rafiqi, Simone Degan, and Mary E. Sunday. “Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia..” Am J Respir Crit Care Med 174, no. 1 (July 1, 2006): 75–83. https://doi.org/10.1164/rccm.200511-1784OC.

PMID
16574933
Full Text

Ashour, Khalid, Lin Shan, Jong Hwan Lee, William Schlicher, Keiji Wada, Etsuko Wada, and Mary E. Sunday. “Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice..” Am J Respir Crit Care Med 173, no. 12 (June 15, 2006): 1377–85. https://doi.org/10.1164/rccm.200507-1014OC.

PMID
16603607
Full Text

Pua, Zarah J., Barbara S. Stonestreet, Anne Cullen, Aliakbar Shahsafaei, Grazyna B. Sadowska, and Mary E. Sunday. “Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids..” J Histochem Cytochem 53, no. 12 (December 2005): 1469–79. https://doi.org/10.1369/jhc.5A6721.2005.

PMID
15956023
Full Text

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