Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Franks, TJ, Colby, TV, Travis, WD, Tuder, RM, Reynolds, HY, Brody, AR, Cardoso, WV, Crystal, RG, Drake, CJ, Engelhardt, J, Frid, M, Herzog, E, Mason, R, Phan, SH, Randell, SH, Rose, MC, Stevens, T, Serge, J, Sunday, ME, Voynow, JA, Weinstein, BM, Whitsett, J, and Williams, MC. "Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function." Proceedings of the American Thoracic Society 5, no. 7 (September 2008): 763-766.

PMID
18757314
Full Text

Crystal, RG, Randell, SH, Engelhardt, JF, Voynow, J, and Sunday, ME. "Airway epithelial cells: current concepts and challenges." Proceedings of the American Thoracic Society 5, no. 7 (September 2008): 772-777. (Review)

PMID
18757316
Full Text

Shan, L, Subramaniam, M, Emanuel, RL, Degan, S, Johnston, P, Tefft, D, Warburton, D, and Sunday, ME. "Centrifugal migration of mesenchymal cells in embryonic lung." Dev Dyn 237, no. 3 (March 2008): 750-757.

PMID
18297731
Full Text

Haley, KJ, Sunday, ME, Porrata, Y, Kelley, C, Twomey, A, Shahsafaei, A, Galper, B, Sonna, LA, and Lilly, CM. "Ontogeny of the eotaxins in human lung." American Journal of Physiology. Lung Cellular and Molecular Physiology 294, no. 2 (February 2008): L214-L224.

PMID
18055844
Full Text

Subramaniam, M, Bausch, C, Twomey, A, Andreeva, S, Yoder, BA, Chang, L, Crapo, JD, Pierce, RA, Cuttitta, F, and Sunday, ME. "Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia." American Journal of Respiratory and Critical Care Medicine 176, no. 9 (November 2007): 902-912.

PMID
17585105
Full Text

Levesque, BM, Zhou, S, Shan, L, Johnston, P, Kong, Y, Degan, S, and Sunday, ME. "NPAS1 regulates branching morphogenesis in embryonic lung." American Journal of Respiratory Cell and Molecular Biology 36, no. 4 (April 2007): 427-434.

PMID
17110583
Full Text

Shan, L, Aster, JC, Sklar, J, and Sunday, ME. "Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 292, no. 2 (February 2007): L500-L509.

PMID
17028268
Full Text

Rosen, D, Lee, J-H, Cuttitta, F, Rafiqi, F, Degan, S, and Sunday, ME. "Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia." American Journal of Respiratory and Critical Care Medicine 174, no. 1 (July 2006): 75-83.

PMID
16574933
Full Text

Ashour, K, Shan, L, Lee, JH, Schlicher, W, Wada, K, Wada, E, and Sunday, ME. "Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice." American Journal of Respiratory and Critical Care Medicine 173, no. 12 (June 2006): 1377-1385.

PMID
16603607
Full Text

Pua, ZJ, Stonestreet, BS, Cullen, A, Shahsafaei, A, Sadowska, GB, and Sunday, ME. "Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids." The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society 53, no. 12 (December 2005): 1469-1479.

PMID
15956023
Full Text

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