Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Sunday, Mary E. “Pulmonary Neuroendocrine Cells and Lung Development..” Endocr Pathol 7, no. 3 (1996): 173–201.

PMID
12114731
Scholars@Duke

Tseng, C. C., M. O. Boylan, L. A. Jarboe, E. K. Williams, M. E. Sunday, and M. M. Wolfe. “Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland..” Mol Cell Endocrinol 115, no. 1 (November 30, 1995): 13–19. https://doi.org/10.1016/0303-7207(95)03665-t.

PMID
8674860
Full Text

Anderson, I. C., D. J. Sugarbaker, R. K. Ganju, D. G. Tsarwhas, W. G. Richards, M. Sunday, L. Kobzik, and M. A. Shipp. “Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts..” Cancer Res 55, no. 18 (September 15, 1995): 4120–26.

PMID
7664289
Scholars@Duke

Sunday, M. E., C. G. Willett, S. A. Graham, V. I. Oreffo, R. I. Linnoila, and H. Witschi. “Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia..” Am J Pathol 147, no. 3 (September 1995): 740–52.

PMID
7677185
Scholars@Duke

King, K. A., J. S. Torday, and M. E. Sunday. “Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism..” Proc Natl Acad Sci U S A 92, no. 10 (May 9, 1995): 4357–61. https://doi.org/10.1073/pnas.92.10.4357.

PMID
7753811
Full Text

Battey, J. F., P. H. Brown, E. R. Gritz, W. K. Hong, B. E. Johnson, D. D. Karp, J. L. Mulshine, G. L. Shaw, D. R. Shopland, and M. E. Sunday. “Primary and Secondary Prevention of Lung Cancer: an International Association for the Study of Lung Cancer workshop..” Lung Cancer 12, no. 1–2 (March 1995): 91–103.

PMID
7600036
Scholars@Duke

Sunday, M. E. “Differential display RT-PCR for identifying novel gene expression in the lung.” American Journal of Physiology  Lung Cellular and Molecular Physiology 269, no. 3 13-3 (January 1, 1995).

Scholars@Duke

Ganju, R. K., M. Sunday, D. G. Tsarwhas, A. Card, and M. A. Shipp. “CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation..” J Clin Invest 94, no. 5 (November 1994): 1784–91. https://doi.org/10.1172/JCI117526.

PMID
7962523
Full Text

Sunday, M. E., C. G. Willett, K. Patidar, and S. A. Graham. “Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia..” Lab Invest 70, no. 6 (June 1994): 875–88.

PMID
8015292
Scholars@Duke

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