Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976


Wuenschell, C. W., M. E. Sunday, G. Singh, P. Minoo, H. C. Slavkin, and D. Warburton. “Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages.” J Histochem Cytochem 44, no. 2 (February 1996): 113–23.

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Tseng, C. C., M. O. Boylan, L. A. Jarboe, E. K. Williams, M. E. Sunday, and M. M. Wolfe. “Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland.” Mol Cell Endocrinol 115, no. 1 (November 30, 1995): 13–19.

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Anderson, I. C., D. J. Sugarbaker, R. K. Ganju, D. G. Tsarwhas, W. G. Richards, M. Sunday, L. Kobzik, and M. A. Shipp. “Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.” Cancer Res 55, no. 18 (September 15, 1995): 4120–26.


Sunday, M. E., C. G. Willett, S. A. Graham, V. I. Oreffo, R. I. Linnoila, and H. Witschi. “Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.” Am J Pathol 147, no. 3 (September 1995): 740–52.


King, K. A., J. S. Torday, and M. E. Sunday. “Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism.” Proc Natl Acad Sci U S A 92, no. 10 (May 9, 1995): 4357–61.

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Battey, J. F., P. H. Brown, E. R. Gritz, W. K. Hong, B. E. Johnson, D. D. Karp, J. L. Mulshine, G. L. Shaw, D. R. Shopland, and M. E. Sunday. “Primary and Secondary Prevention of Lung Cancer: an International Association for the Study of Lung Cancer workshop.” Lung Cancer 12, no. 1–2 (March 1995): 91–103.

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Sunday, M. E. “Differential display RT-PCR for identifying novel gene expression in the lung.” American Journal of Physiology  Lung Cellular and Molecular Physiology 269, no. 3 13-3 (January 1, 1995).


Ganju, R. K., M. Sunday, D. G. Tsarwhas, A. Card, and M. A. Shipp. “CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation.” J Clin Invest 94, no. 5 (November 1994): 1784–91.

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